Results 1 to 10 of about 142,225 (163)

Pyruvate kinase activators for treatment of pyruvate kinase deficiency. [PDF]

Hematology Am Soc Hematol Educ Program, 2023
Abstract Pyruvate kinase (PK) deficiency is a congenital hemolytic anemia with wide-ranging clinical symptoms and complications associated with significant morbidity and reduced health-related quality of life in both children and adults.
Grace RF.
europepmc   +3 more sources

HBV-Induced Pyruvate Increases Lactylation of Pyruvate Kinase M2 (PKM2) at K206 to Promote Liver Fibrosis [PDF]

Pathogens
We previously demonstrated that HBV promotes liver fibrosis through the enhanced production of pyruvate. Pyruvate kinase M2 (PKM2), a key enzyme in pyruvate metabolism, plays an important role in liver fibrogenesis. Recently, lactylation of PKM2 has been
Wenxian Wen, Qin Du, Shuhan Li, Youmin Yang, Xianding Wang, Shasha Li, Yujia Li, Shilin Li, Chunhui Yang, He Xie, Xiaoqiong Duan, Limin Chen   +11 more
doaj   +2 more sources

Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity [PDF]

mBio
Guanosine triphosphate (GTP) is essential for macromolecular biosynthesis, and its intracellular levels are tightly regulated in bacteria. Loss of the alarmone (p)ppGpp disrupts GTP regulation in Bacillus subtilis, causing cell death in the presence of ...
Fukang She, Kuanqing Liu, Brent W. Anderson, Tippapha Pisithkul, Yanxiu Li, Danny K. Fung, Tyler McCue, William Mulhern, Daniel Amador-Noguez, Jue D. Wang   +9 more
doaj   +2 more sources

Pyruvate Kinase, Inflammation and Periodontal Disease

Pathogens, 2021
Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-
Melissa M. Grant
doaj   +3 more sources

Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow [PDF]

mSystems
Gluconeogenesis, the reciprocal pathway of glycolysis, is an energy-consuming process that generates glycolytic intermediates from non-carbohydrate sources. In this study, we demonstrate that robust and efficient gluconeogenesis in bacteria relies on the
Fukang She, Brent W. Anderson, Daven B. Khana, Shenwei Zhang, Wieland Steinchen, Danny K. Fung, Nathalie G. Lesser, Lauren N. Lucas, David M. Stevenson, Theresa J. Astmann, Gert Bange, Jan-Peter van Pijkeren, Daniel Amador-Noguez, Jue D. Wang   +13 more
doaj   +2 more sources

Diagnostic value of plasma M2-pyruvate kinase in Egyptian patients with colorectal cancer [PDF]

Al-Azhar International Medical Journal, 2022
Background: M2-pyruvate kinase (M2-PK) plays an important role in tumor metabolism, and new studies have shown that M2-PK can operate as both a protein kinase and a transcription factor coactivator.
Islam Ghoniem, Fathy Elghamry, Ashraf Abobakr, mohamed khidr, mohamed alboraie   +4 more
doaj   +1 more source

A Sri Lankan girl with a new genetic variant in the PKLR gene causing pyruvate kinase deficiency: a case report

Journal of Medical Case Reports, 2021
Background Erythrocyte pyruvate kinase is expressed under the control of the PKLR gene located on chromosome 1q21. Pyruvate kinase catalyzes the final steps of the glycolytic pathway and creates 50% of the red cell total adenosine triphosphate.
Ahalyaa Sivashangar, Lallindra Gooneratne, Barnaby Clark, David Rees, Saroj Jayasinghe, Claire Laas   +5 more
doaj   +1 more source

Pyruvate kinase phosphatase [PDF]

FEBS Letters, 1981
1. Introduction Liver pyruvate kinase can be phosphorylated and simultaneously inactivated by CAMP-dependent pro- tein kinase; the inactivated enzyme can be reactivated by a multifunctional protein phosphatase (review [ 13). The inactivation of pyruvate kinase has been observed in isolated hepatocytes incubated in the presence of glucagon and in this ...
Jett, Mary-Frances, Hue, Louis, Hers, Henri-Géry   +2 more
openaire   +2 more sources

Suppressed “Warburg Effect” in Nasopharyngeal Carcinoma Via the Inhibition of Pyruvate Kinase Type M2-Mediated Energy Generation Pathway

Technology in Cancer Research & Treatment, 2020
Warburg effect describes the abnormal energy metabolism in cancer cells and pyruvate kinase type M2 is involved in the regulation of this effect.
Penglong Zhao MBBS, Mengyan Zhou MMed, Ruixiang Chen MBBS, Renjie Su MMed   +3 more
doaj   +1 more source

Protein kinase function of pyruvate kinase M2 and cancer

Cancer Cell International, 2020
Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation.
Xun Chen, Shangwu Chen, Dongsheng Yu
doaj   +1 more source