Results 41 to 50 of about 149,531 (302)
Pharmacological Research - Modern Chinese Medicine, 2022 Background: Sheng-Mai San extracts (SMSE), derived from a Chinese medicine formula Sheng-Mai San, benefits prevention and treatment of cardiovascular disease.
Chunhua Liu +6 more
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
HeliyonPyruvate kinase deficiency is a rare hereditary erythrocyte enzyme disease caused by mutations in the pyruvate kinase liver and red blood cell gene. The clinical presentations of pyruvate kinase deficiency are significantly heterogeneous, ranging from ...
Yang Wang +13 more
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Isoform switch of pyruvate kinase M1 indeed occurs but not to pyruvate kinase M2 in human tumorigenesis. [PDF]
PLoS ONE, 2015 Muscle type of pyruvate kinase (PKM) is one of the key mediators of the Warburg effect and tumor metabolism. Due to alternative splicing, there are at least 12 known isoforms of the PKM gene, of which PKM1 and PKM2 are two major isoforms with only a 23 ...
Cheng Zhan +7 more
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Detection of H2O2-induced changes in redox status of tumor-type pyruvate kinase（PKM2） [PDF]
, 2013 Recent studies shed light on a crucial function of M2 isoform of mammalian pyruvate kinase（PkM2）on tumor cell growth. Pyruvate kinase activity of PkM2 was shown to be negatively regulated by growth factors or reactive oxygen species（ros）.
久下, 周佐 +14 more
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Effect and Regulation of Pyruvate on Bacillomycin D Synthesis
Shipin gongye ke-ji, 2022 Objective: This paper mainly studied the effects and regulation of exogenous addition of pyruvate, overexpression of pyruvate kinase and acetyl-CoA synthase on the synthesis of Bacillomycin D. Methods: In this study, B. amyloliquefaciens fmbJ was used as
Wenjie MA +8 more
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The phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate node in C. glutamicum.
, 2016 Abbreviations: AK, acetate kinase; PTA, phosphotransacetylase; CA, carbonic anhydrase; CS, citrate synthase; ACN, aconitase; ICD, isocitrate dehydrogenase; OGDHC, oxoglutarate dehydrogenase complex; ICL, isocitrate lyase; MS, malate synthase; MalE, malic
Bernhard J. Eikmanns (2633149) +1 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular heterogeneity of pyruvate kinase deficiency
Haematologica, 2020 Red cell pyruvate kinase (PK) deficiency is the most common glycolytic defect associated with congenital non-spherocytic hemolytic anemia. The disease, transmitted as an autosomal recessive trait, is caused by mutations in the PKLR gene and is ...
Paola Bianchi, Elisa Fermo
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