Results 41 to 50 of about 1,722,299 (336)
Prevalence of pyruvate kinase deficiency: A systematic literature review
European Journal of Haematology, 2020 Pyruvate kinase deficiency (PK deficiency) is a rare disorder caused by compound heterozygosity or homozygosity for > 300 mutations in the PKLR gene. To understand PK deficiency prevalence, we conducted a systematic literature review.
M. Secrest +6 more
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Research Progress on the Effect of Post-translational Modification of Pyruvate Kinase on Meat Quality [PDF]
Shipin KexueThe postmortem conversion of muscle to meat goes through a series of complex physiological and biochemical changes, among which protein post-translational modifications (PTMs) are key factors affecting meat quality.
HUANG Xiaolan, CHEN Li, REN Chi, BAI Yuqiang, HOU Chengli, LI Xin, LUO Ruiming, ZHANG Dequan
doaj +1 more source
Exploration of Host Genetic Factors associated with Malaria, 2020 Pyruvate kinase deficiency is an inherited disorder that affects red blood cells, which carry oxygen to the body's tissues. People with this disorder have a condition known as chronic hemolytic anemia, in which red blood cells are broken down (undergo ...
T. Qidwai
semanticscholar +1 more source
Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency.
New England Journal of Medicine, 2019 BACKGROUND Pyruvate kinase deficiency is caused by mutations in PKLR and leads to congenital hemolytic anemia. Mitapivat is an oral, small-molecule allosteric activator of pyruvate kinase in red cells.
R. Grace +20 more
semanticscholar +1 more source
Regulation of mammalian pyruvate dehydrogenase kinase [PDF]
, 1997 It is generally believed that mammalian pyruvate dehydrogenase kinase is a heterodimer consisting of catalytic and regulatory subunits. However, the contribution of the two subunits to the kinase-mediated signal transduction has remained undefined.
Popov, Kirill M, Kirill M Popov
core +1 more source
Journal of Medical Case Reports, 2022 Background Pyruvate kinase deficiency is an exceptionally rare autosomal recessive Mendelian disorder caused by bi-allelic pathogenic variants in the PKLR gene.
Atta Ur Rehman +3 more
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PYRUVATE KINASE M2: A SIMPLE MOLECULE WITH COMPLEX FUNCTIONS
Free Radical Biology & Medicine, 2019 Pyruvate kinase M2 is a critical enzyme that regulates cell metabolism and growth under different physiological conditions. In its metabolic role, pyruvate kinase M2 catalyzes the last glycolytic step which converts phosphoenolpyruvate to pyruvate with ...
Mohammed Alquraishi +7 more
semanticscholar +1 more source
Cell Reports, 2019 Summary: Pyruvate kinase is an important enzyme in glycolysis and a key metabolic control point. We recently observed a pyruvate kinase liver isoform (PKL) phosphorylation site at S113 that correlates with insulin resistance in rats on a 3 day high-fat ...
Brandon M. Gassaway +18 more
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Pyruvate Kinase, Inflammation and Periodontal Disease
Pathogens, 2021 Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-
Melissa M. Grant
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Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation.
JCI Insight, 2019 Th1 and Th17 are important in the pathogenesis of autoimmune diseases and they depend on glycolysis as a source of energy. T cell antigen receptor signaling phosphorylates a serine/threonine kinase, calcium/calmodulin-dependent protein kinase IV (CaMK4),
M. Kono +11 more
semanticscholar +1 more source