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Research Progress on the Effect of Post-translational Modification of Pyruvate Kinase on Meat Quality [PDF]
Shipin KexueThe postmortem conversion of muscle to meat goes through a series of complex physiological and biochemical changes, among which protein post-translational modifications (PTMs) are key factors affecting meat quality.
HUANG Xiaolan, CHEN Li, REN Chi, BAI Yuqiang, HOU Chengli, LI Xin, LUO Ruiming, ZHANG Dequan
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A fluorometric method for the assay of protein kinase activity [PDF]
, 2018 Protein kinases constitute one of the largest protein families in nature. Current methods to assay their activity involve the use of radioactive ATP or very expensive reagents.
Figueroa, Carlos Maria +4 more
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Journal of Medical Case Reports, 2022 Background Pyruvate kinase deficiency is an exceptionally rare autosomal recessive Mendelian disorder caused by bi-allelic pathogenic variants in the PKLR gene.
Atta Ur Rehman +3 more
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Journal of Experimental Medicine, 2019 This study identifies a novel pathway through which PCa selectively metastasizes to bone. PCa cells produce exosomes that transfer pyruvate kinase M2 to BMSCs, which in turn produce CXCL12 that promotes PCa invasion and growth.
Jinlu Dai +6 more
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The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation [PDF]
, 2015 Autophagy is a self-degradative physiological process by which the cell removes worn-out or damaged components. Constant at basal level it may become highly active in response to cellular stress. The type 2 transglutaminase (TG2), which accumulates under
Belkin +61 more
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Pyruvate Kinase, Inflammation and Periodontal Disease
Pathogens, 2021 Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-
Melissa M. Grant
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Pyruvate kinase M2: A simple molecule with complex functions.
Free Radical Biology & Medicine, 2019 Pyruvate kinase M2 is a critical enzyme that regulates cell metabolism and growth under different physiological conditions. In its metabolic role, pyruvate kinase M2 catalyzes the last glycolytic step which converts phosphoenolpyruvate to pyruvate with ...
Mohammed Alquraishi +7 more
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miRNAs link metabolic reprogramming to oncogenesis [PDF]
, 2013 The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M +2 more
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[Pyruvate kinase deficiency]. [PDF]
Nihon rinsho. Japanese journal of clinical medicine, 1974 PK deficiency is the most common and well characterized erythroenzymopathy in the Embden-Meyerhof glycolytic pathway associated with hereditary hemolytic anemia. History of discovery, clinical features, biochemical studies, as well as recent studies on molecular level were reviewed, with a stress on our own studies. As reference materials, Tables 2 and
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Transcriptional Regulation of Pyruvate Dehydrogenase Kinase [PDF]
Diabetes & Metabolism Journal, 2012 The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes.
Ji Yun Jeong +3 more
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