Results 71 to 80 of about 1,722,299 (336)

Isoform switch of pyruvate kinase M1 indeed occurs but not to pyruvate kinase M2 in human tumorigenesis. [PDF]

PLoS ONE, 2015
Muscle type of pyruvate kinase (PKM) is one of the key mediators of the Warburg effect and tumor metabolism. Due to alternative splicing, there are at least 12 known isoforms of the PKM gene, of which PKM1 and PKM2 are two major isoforms with only a 23 ...
Cheng Zhan, Li Yan, Lin Wang, Jun Ma, Wei Jiang, Yongxing Zhang, Yu Shi, Qun Wang   +7 more
doaj   +1 more source

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

Nature Medicine, 2017
Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic options for preventing its progression are limited. To identify novel therapeutic strategies, we studied protective factors for DN using proteomics on glomeruli from ...
W. Qi, H. Keenan, Qian Li, A. Ishikado, A. Kannt, T. Sadowski, M. Yorek, I-Hsien Wu, Samuel M. Lockhart, L. Coppey, A. Pfenninger, C. Liew, G. Qiang, Alison M. Burkart, Stephanie M. Hastings, D. Pober, C. Cahill, M. Niewczas, William J. Israelsen, Liane J. Tinsley, I. Stillman, P. Amenta, E. Feener, M. V. Vander Heiden, R. Stanton, George L. King   +25 more
semanticscholar   +1 more source

[Pyruvate kinase deficiency].

Nihon rinsho. Japanese journal of clinical medicine, 1973
PK deficiency is the most common and well characterized erythroenzymopathy in the Embden-Meyerhof glycolytic pathway associated with hereditary hemolytic anemia. History of discovery, clinical features, biochemical studies, as well as recent studies on molecular level were reviewed, with a stress on our own studies. As reference materials, Tables 2 and
openaire   +4 more sources

ATP‐Mediated Bidirectional Communication Between Natural and Artificial Cells for Controlled Bioreactions

Advanced Functional Materials, EarlyView.
Establishment of bidirectional communication behavior between natural and artificial cells. The first type of communication from natural dendritic cells to artificial polymeric cells was achieved via ATP release after cell lysis. The released ATP was taken up via gated UV‐controlled permeability increase of the polymeric membrane for performing ...
Ilona Kalte, Tsvetomir Ivanov, Leonhard Seufert, Shoupeng Cao, Lucas Caire da Silva, Volker Mailänder, Katharina Landfester   +6 more
wiley   +1 more source

Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow

mSystems
Gluconeogenesis, the reciprocal pathway of glycolysis, is an energy-consuming process that generates glycolytic intermediates from non-carbohydrate sources. In this study, we demonstrate that robust and efficient gluconeogenesis in bacteria relies on the
Fukang She, Brent W. Anderson, Daven B. Khana, Shenwei Zhang, Wieland Steinchen, Danny K. Fung, Nathalie G. Lesser, Lauren N. Lucas, David M. Stevenson, Theresa J. Astmann, Gert Bange, Jan-Peter van Pijkeren, Daniel Amador-Noguez, Jue D. Wang   +13 more
doaj   +1 more source

Effect and Regulation of Pyruvate on Bacillomycin D Synthesis

Shipin gongye ke-ji, 2022
Objective: This paper mainly studied the effects and regulation of exogenous addition of pyruvate, overexpression of pyruvate kinase and acetyl-CoA synthase on the synthesis of Bacillomycin D. Methods: In this study, B. amyloliquefaciens fmbJ was used as
Wenjie MA, Yi ZHONG, Zhaoxin LU, Ping ZHANG, Shilei CHEN, Miao QIN, Fengxia LÜ, Haizhen ZHAO, Xiaomei BIE   +8 more
doaj   +1 more source

SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice.

Cell Reports, 2017
LPS-activated macrophages undergo a metabolic shift from dependence on mitochondria-produced ATP to reliance on aerobic glycolysis, where PKM2 is a critical determinant.
Fang Wang, Ke Wang, Wei Xu, Shimin Zhao, D. Ye, Yi Wang, Ying-Hua Xu, Li-Sha Zhou, Y. Chu, Cui-Ping Zhang, Xue Qin, Peng-Yuan Yang, Hongxiu Yu   +12 more
semanticscholar   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Molecular heterogeneity of pyruvate kinase deficiency

Haematologica, 2020
Red cell pyruvate kinase (PK) deficiency is the most common glycolytic defect associated with congenital non-spherocytic hemolytic anemia. The disease, transmitted as an autosomal recessive trait, is caused by mutations in the PKLR gene and is ...
Paola Bianchi, Elisa Fermo
doaj   +1 more source

The role of pyruvate kinase M2 in anticancer therapeutic treatments

Oncology Letters, 2019
Cancer cells are characterized by a high glycolytic rate, which leads to energy regeneration and anabolic metabolism; a consequence of this is the abnormal expression of pyruvate kinase isoenzyme M2 (PKM2).
Qiongli Su, Shengping Luo, Qiu-hui Tan, Jun Deng, Sichun Zhou, Mei Peng, Ting Tao, Xiaoping Yang   +7 more
semanticscholar   +1 more source