Results 91 to 100 of about 149,531 (302)

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

, 2022
Altered metabolism helps sustain cancer cell proliferation and survival. Most cancers, including prostate cancers, express the M2 splice isoform of pyruvate kinase (PKM2), which can support anabolic metabolism to support cell proliferation. However, Pkm2
Mak, Howard H., Carracedo, Arkaitz, Cantley, Lewis C, Bellinger, Gary, Pandolfi, Pier Paolo, Cantley, Lewis C., Davidson, Shawn M., Thomas, Craig J, Jha, Abhishek, Courtney, Kevin D, DePinho, Ronald A., Thomas, Craig J., Dayton, Talya L, Bronson, Roderick T, Courtney, Kevin D., Fanelli, G. N., Israelsen, William J, Davidson, Shawn M, Liu, Amy C, Horner, James W., Sehgal, Raghav, Liu, Amy C., Heyman, Julia E., Dayton, Talya L., Bronson, Roderick T., Fanelli, Giuseppe Nicolò, Loda, Massimo, Schmidt, Daniel R., DePinho, Ronald A, Israelsen, William J., O'Brien, James P., Vander Heiden, Matthew G, Heyman, Julia E, Mak, Howard H, Freinkman, Elizaveta, Vander Heiden, Matthew G., Malstrom, Scott, Schmidt, Daniel R, O'Brien, James P, Horner, James W   +39 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Enzymatic Activity Assay Development for Pyruvate Kinase

, 2019
Pyruvate kinase (PK) is an enzyme that catalyzes the last step in the process of glycolysis. PK transfers the phosphate group from phosphoenolpyruvate to ADP, thereby generating one molecule of ATP and pyruvate.
Truong, Nhat
core  

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Isolation, purification and characterization of pyruvate kinase from Staphylococcus aureus : a potential drug target [PDF]

Journal of Clinical and Scientific Research, 2014
Background: With emergence of multidrug-resistant strains of Staphylococcus aureus, there is an urgent need for the development of new antimicrobials which are narrow and pathogen specific.
K. Venkatesh, L. Srikanth, V. Swarupa, S. Yeswanth, U.V. Prasad, D. Vasu, G.P. Vishnuvardhan, P. Srinivas, P. Santhoshkumar, G. Sowjenya, P.V.G.K. Sarma, Y. Nandakumar, Abhijit Chaudhary   +12 more
doaj  

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells

Stem Cell Reports, 2015
Pyruvate kinase deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene. Erythrocytes from PKD patients show an energetic imbalance causing chronic non-spherocytic hemolytic anemia, as pyruvate kinase defects impair ...
Zita Garate, Oscar Quintana-Bustamante, Ana M. Crane, Emmanuel Olivier, Laurent Poirot, Roman Galetto, Penelope Kosinski, Collin Hill, Charles Kung, Xabi Agirre, Israel Orman, Laura Cerrato, Omaira Alberquilla, Fatima Rodriguez-Fornes, Noemi Fusaki, Felix Garcia-Sanchez, Tabita M. Maia, Maria L. Ribeiro, Julian Sevilla, Felipe Prosper, Shengfang Jin, Joanne Mountford, Guillermo Guenechea, Agnes Gouble, Juan A. Bueren, Brian R. Davis, Jose C. Segovia   +26 more
doaj   +1 more source

The effect of glucose on cardiac AMP-activated protein kinase

, 2009
AMP-activated protein kinase (AMPK) serves as an energy-sensing protein that is activated by a variety of metabolic stresses. Recent studies suggest that AMPK is also regulated by hormones and by nutrients such as glucose and fatty acids.
Tabidi, I.
core  

Regulation of pyruvate kinase by 6-phosphogluconate in isolated hepatocytes

, 1981
Isolated liver parenchymal cells from rats fed a 65% sucrose diet for 14 days were incubated in the presence and absence of 10(-6) M glucagon. The pyruvate kinase obtained from homogenates of the glucagon-treated cells displayed and increased Ks 0.5 for ...
S. B. Smith, R. A. Freedland
core   +1 more source