Results 101 to 110 of about 1,722,299 (336)
Novel mutations associated with pyruvate kinase deficiency in Brazil
Hematology, Transfusion and Cell Therapy, 2018 Background: Pyruvate kinase deficiency is a hereditary disease that affects the glycolytic pathway of the red blood cell, causing nonspherocytic hemolytic anemia.
Maria Carolina Costa Melo Svidnicki +9 more
doaj +1 more source
A simple and reliable method for determination of optimum pH in coupled enzyme assays
BioTechniques, 2020 Determination of the optimum pH in a coupled enzyme assay poses significant challenges because altering the pH of the reaction mixture can affect the performance of both enzymes.
Lee Bowman +7 more
doaj +1 more source
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells
Nature Communications, 2018 Despite their inherent proximity to circulating oxygen and nutrients, endothelial cells (ECs) oxidize only a minor fraction of glucose in mitochondria, a metabolic specialization that is poorly understood. Here we show that the glycolytic enzyme pyruvate
Oliver A. Stone +15 more
semanticscholar +1 more source
The effect of glucose on cardiac AMP-activated protein kinase [PDF]
, 2009 AMP-activated protein kinase (AMPK) serves as an energy-sensing protein that is activated by a variety of metabolic stresses. Recent studies suggest that AMPK is also regulated by hormones and by nutrients such as glucose and fatty acids.
Tabidi, I.
core
UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression
Advanced Science, EarlyView.UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma +14 more
wiley +1 more source
Erythrocytic Pyruvate Kinase and Malondialdehyde Levels in Acute Leukaemia Patients [PDF]
Journal of Clinical and Diagnostic Research, 2012 Introduction: Many acquired enzymopathies have been reported in patients with acute leukaemia. Oxidative stress is also found to be increased in acute leukaemia, which can be indicated by the increased malondialdehyde (MDA) levels.
Veena Singh +5 more
doaj
Endothelial pyruvate kinase M2 maintains vascular integrity
Journal of Clinical Investigation, 2018 The M2 isoform of pyruvate kinase (PKM2) is highly expressed in most cancer cells, and has been studied extensively as a driver of oncogenic metabolism. In contrast, the role of PKM2 in nontransformed cells is little studied, and nearly nothing is known ...
Boa Kim +7 more
semanticscholar +1 more source
Pyruvate kinase and the "high ATP syndrome"
, 1984 The erythrocytes of a patient with the so-called "high ATP syndrome" were characterized by a high ATP content and low 2,3-diphosphoglycerate level. The pyruvate kinase activity was specifically increased (about twice the normal level).
Roos, D, Jansen, G, Staal, G E
core +1 more source
Purification of a novel pyruvate kinase from a green alga [PDF]
, 1989 A chloroplast pyruvate kinase has been purified to homogeneity from the green alga Selenastrum minutum. The subunit composition of the enzyme differs markedly from pyruvate kinases from other sources.
David T. Dennis +5 more
core +1 more source