Results 121 to 130 of about 1,722,299 (336)

Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype

Frontiers in Immunology, 2019
Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits the pyruvate dehydrogenase-mediated conversion of ...
Byong-Keol Min, Sungmi Park, Hyeon-Ji Kang, Dong Wook Kim, H. Ham, Chae-Myeong Ha, Byung-Jun Choi, Jung-Yi Lee, C. J. Oh, E. Yoo, Hui Eon Kim, Byung-Gyu Kim, Jae-Han Jeon, D. Hyeon, D. Hwang, Yong-Hoon Kim, Chul-Ho Lee, Taeho Lee, Jung-whan Kim, Yeon-Kyung Choi, K. Park, A. Chawla, Jongsoon Lee, Robert A. Harris, In-kyu Lee   +24 more
semanticscholar   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression

Neurobiology of Disease, 2006
Parkinson disease (PD) is the second-most common age-related neurodegenerative disease and is characterized by the selective destruction of dopaminergic neurons. Increasing evidence indicates that oxidative stress plays a crucial role in the pathogenesis
F.J. Fernandez-Gomez, M.D. Pastor, E.M. Garcia-Martinez, R. Melero-Fernandez de Mera, M. Gou-Fabregas, M. Gomez-Lazaro, S. Calvo, R.M. Soler, M.F. Galindo, J. Jordán   +9 more
doaj   +1 more source

Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin

Scientific Reports, 2017
Chemoresistance to cisplatin is a principal cause of treatment failure and mortality of advanced bladder cancer (BC). The underlying mechanisms remain unclear, which hinders the development of preventive strategies.
Xing Wang, Feng-Lin Zhang, Xue-Ru Wu
semanticscholar   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Glucose metabolism in cancer - the saga of pyruvate kinase continues

Cancer Cell, 2018
Altered glucose metabolism is common in cancer. In this issue of Cancer Cell, Morita et al. report new mouse models that express specific isoforms of pyruvate kinase to study glycolysis in tumors and report several unanticipated findings that challenge ...
Annamarie E. Allen, J. Locasale
semanticscholar   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study

Haematologica, 2018
Pyruvate kinase (PK) deficiency is the most common red cell glycolytic enzyme defect causing hereditary non-spherocytic hemolytic anemia. Current treatments are mainly supportive and include red cell transfusions and splenectomy.[1][1] Regular red cell ...
E. V. van Beers, S. van Straaten, D. Morton, W. Barcellini, S. Eber, B. Glader, H. Yaish, S. Chonat, J. Kwiatkowski, J. Rothman, Mukta Sharma, E. Neufeld, S. Sheth, J. Despotovic, N. Kollmar, D. Pospíšilová, C. Knoll, K. Kuo, Y. Pastore, A. Thompson, P. Newburger, Y. Ravindranath, Winfred C. Wang, M. Wlodarski, Heng Wang, S. Holzhauer, V. Breakey, M. Verhovsek, J. Kunz, Melissa A. McNaull, M. Rose, Heather A. Bradeen, K. Addonizio, Anran Li, Hasan Al-Sayegh, W. London, R. Grace   +36 more
semanticscholar   +1 more source

Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations

Advanced Science, EarlyView.
Tendon interfascicular and fascicular matrix cells are isolated and cultured, revealing distinct phenotypes and mechanosensitive responses. Interfascicular matrix cells exhibit marked stiffness‐dependent phenotypic plasticity, whereas fascicular matrix cells remain comparatively stable.
S. E. Grossemy, D. E. Zamboulis, N. S. Khatib, M. R. Fazal, C. C. Gains, A. Giannopoulos, T. Hopkins, C. Bevan, Y. Aggarwal, M. M. Knight, H. R. C. Screen   +10 more
wiley   +1 more source

Isolation, purification and characterization of pyruvate kinase from Staphylococcus aureus : a potential drug target [PDF]

Journal of Clinical and Scientific Research, 2014
Background: With emergence of multidrug-resistant strains of Staphylococcus aureus, there is an urgent need for the development of new antimicrobials which are narrow and pathogen specific.
K. Venkatesh, L. Srikanth, V. Swarupa, S. Yeswanth, U.V. Prasad, D. Vasu, G.P. Vishnuvardhan, P. Srinivas, P. Santhoshkumar, G. Sowjenya, P.V.G.K. Sarma, Y. Nandakumar, Abhijit Chaudhary   +12 more
doaj