Results 31 to 40 of about 149,531 (302)

A novel homozygous missense variant p.D339N in the PKLR gene correlates with pyruvate kinase deficiency in a Pakistani family: a case report

Journal of Medical Case Reports, 2022
Background Pyruvate kinase deficiency is an exceptionally rare autosomal recessive Mendelian disorder caused by bi-allelic pathogenic variants in the PKLR gene.
Atta Ur Rehman, Abdur Rashid, Zubair Hussain, Khadim Shah   +3 more
doaj   +1 more source

Pyruvate Kinase, Inflammation and Periodontal Disease

Pathogens, 2021
Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-
Melissa M. Grant
doaj   +1 more source

Metabolic responses of primary and transformed cells to intracellular Listeria monocytogenes. [PDF]

, 2012
The metabolic response of host cells, in particular of primary mammalian cells, to bacterial infections is poorly understood. Here, we compare the carbon metabolism of primary mouse macrophages and of established J774A.1 cells upon Listeria monocytogenes
Wolfgang Eisenreich (108576), Anette Schulz (108573), Andreas Götz (108569), Gillmaier, Nadine, Götz, Andreas, Nadine Gillmaier, Schulz, Anette, Werner Goebel, Goebel, Werner, Eisenreich, Wolfgang, Werner Goebel (7241), Andreas Götz, Anette Schulz, Wolfgang Eisenreich, Nadine Gillmaier (108566)   +14 more
core   +1 more source

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase [PDF]

Diabetes & Metabolism Journal, 2012
The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes.
Ji Yun Jeong, Nam Ho Jeoung, Keun-Gyu Park, In-Kyu Lee   +3 more
doaj   +1 more source

ROLE OF HOST CELL GLYCOLYTIC PROTEINS; ALPHA ENOLASE AND PYRUVATE KINASE IN INFLUENZA A VIRUS INFECTED CELLS

International Journal of Infectious Diseases, 2023
Intro: Influenza A virus, a respiratory pathogen known to manipulate various cellular metabolic processes including glycolysis. Our earlier studies demonstrated the interaction of influenza A viral structural proteins; nucleoprotein and matrix protein ...
P. Goyal, M.S. Rajala
doaj   +1 more source

Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production

Cell Reports, 2019
Summary: Pyruvate kinase is an important enzyme in glycolysis and a key metabolic control point. We recently observed a pyruvate kinase liver isoform (PKL) phosphorylation site at S113 that correlates with insulin resistance in rats on a 3 day high-fat ...
Brandon M. Gassaway, Rebecca L. Cardone, Anil K. Padyana, Max C. Petersen, Evan T. Judd, Sebastian Hayes, Shuilong Tong, Karl W. Barber, Maria Apostolidi, Abudukadier Abulizi, Joshua B. Sheetz, Kshitiz, Hans R. Aerni, Stefan Gross, Charles Kung, Varman T. Samuel, Gerald I. Shulman, Richard G. Kibbey, Jesse Rinehart   +18 more
doaj   +1 more source

Probing Conformational Feature of a Recombinant Pyruvate Kinase by Limited Proteolysis [PDF]

Journal of Sciences, Islamic Republic of Iran, 2013
Pyruvate kinase is a key enzyme in glycolytic pathway that catalyzes the transphosphorylation between phosphoenolpyruvate and ADP to yield ATP and Pyruvate.
M. Banijamali, S. Hosseinkhani, J. Fuladi   +2 more
doaj  

Characterizing the Effect of the Lysine Deacetylation Modification on Enzyme Activity of Pyruvate Kinase I and Pathogenicity of Vibrio alginolyticus

Frontiers in Veterinary Science, 2022
Pyruvate kinase I (PykF) is one of the key enzymes of glycolysis and plays a crucial role in bacterial metabolism. Several acetylation sites of Vibrio alginolyticus PykF were reported in previous studies and then 11 sites were first verified in this ...
Zhou Xu, Zhou Xu, Zhou Xu, Linjing Wang, Linjing Wang, Linjing Wang, Xudong Wang, Xudong Wang, Xudong Wang, Mingyue Wan, Mingyue Wan, Mingyue Wan, Mei Tang, Mei Tang, Mei Tang, Yu Ding, Yu Ding, Yu Ding   +17 more
doaj   +1 more source

Malic Acid Production by Saccharomyces cerevisiae: Engineering of Pyruvate Carboxylation, Oxaloacetate Reduction, and Malate Export

, 2008
Malic acid is a potential biomass-derivable "building block" for chemical synthesis. Since wild-type Saccharomyces cerevisiae strains produce only low levels of malate, metabolic engineering is required to achieve efficient malate production with this ...
Van Maris, A.J.A. (author), Dijkema, C., Van Winden, W.A. (author), Winden, W.A., van, Dijkema, C. (author), Zelle, R.M. (author), Van Maris, A.J.A., Van Winden, W.A., De Hulster, E., Geertman, J.M., Pronk, J.T. (author), Hulster, E., de, Geertman, J.M.A., Winkler, A.A. (author), Van Dijken, J.P., Pronk, J.T., Winkler, A.A., De Hulster, E. (author), De Waard, P. (author), Geertman, J.M. (author), Waard, P., de, Zelle, R.M., De Waard, P., Van Dijken, J.P. (author)   +23 more
core   +1 more source

Pyruvate kinase deficiency mimicking congenital dyserythropoietic anemia type I

The Turkish Journal of Pediatrics, 2022
Background. Pyruvate kinase (PK) deficiency is the most common enzyme abnormality in the glycolytic pathway. Here, we describe two siblings with PK deficiency that mimicked congenital dyserythropoietic anemia (CDA) type I. Case.
Ayça Koca Yozgat, Arzu Yazal Erdem, Dilek Kaçar, Namık Yaşar Özbek, Neşe Yaralı   +4 more
doaj   +1 more source