Results 21 to 30 of about 1,270,348 (335)

Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow [PDF]

mSystems
Gluconeogenesis, the reciprocal pathway of glycolysis, is an energy-consuming process that generates glycolytic intermediates from non-carbohydrate sources. In this study, we demonstrate that robust and efficient gluconeogenesis in bacteria relies on the
Fukang She, Brent W. Anderson, Daven B. Khana, Shenwei Zhang, Wieland Steinchen, Danny K. Fung, Nathalie G. Lesser, Lauren N. Lucas, David M. Stevenson, Theresa J. Astmann, Gert Bange, Jan-Peter van Pijkeren, Daniel Amador-Noguez, Jue D. Wang   +13 more
doaj   +2 more sources

Pyruvate Kinase PKM [PDF]

Definitions, 2020
Pyruvate kinase PKM (531 aa, ~58 kDa) is encoded by the human PKM gene. This protein is involved in muscle cell glycolysis and may play a role in bacterial pathogenesis.

semanticscholar   +2 more sources

Pyruvate Kinase Measurement [PDF]

Definitions, 2020
pyruvate

semanticscholar   +2 more sources

Pyruvate Kinase M2 Role in Cardiovascular Repair [PDF]

Cells
Adult cardiomyocytes (CMs) lose their proliferative capacity shortly after birth, posing a major challenge for cardiac repair following injury such as myocardial infarction (MI).
Mohd Rihan, Lior Zangi, Ajit Magadum
doaj   +2 more sources

[Pyruvate kinase]. [PDF]

Postępy Higieny i Medycyny Doświadczalnej, 2020
J. Jedrzejak
semanticscholar   +3 more sources

Pyruvate kinase phosphatase [PDF]

FEBS Letters, 1981
1. Introduction Liver pyruvate kinase can be phosphorylated and simultaneously inactivated by CAMP-dependent pro- tein kinase; the inactivated enzyme can be reactivated by a multifunctional protein phosphatase (review [ 13). The inactivation of pyruvate kinase has been observed in isolated hepatocytes incubated in the presence of glucagon and in this ...
Jett, Mary-Frances, Hue, Louis, Hers, Henri-Géry   +2 more
openaire   +2 more sources

From meadows to milk to mucosa – adaptation of Streptococcus and Lactococcus species to their nutritional environments [PDF]

, 2012
Lactic acid bacteria (LAB) are indigenous to food-related habitats as well as associated with the mucosal surfaces of animals. The LAB family Streptococcaceae consists of the genera Lactococcus and Streptococcus.
Kok, Jan,, Kuipers, Oscar P.,, Price, Claire E.,, Zeyniyev, Araz,   +3 more
core   +13 more sources

A Sri Lankan girl with a new genetic variant in the PKLR gene causing pyruvate kinase deficiency: a case report

Journal of Medical Case Reports, 2021
Background Erythrocyte pyruvate kinase is expressed under the control of the PKLR gene located on chromosome 1q21. Pyruvate kinase catalyzes the final steps of the glycolytic pathway and creates 50% of the red cell total adenosine triphosphate.
Ahalyaa Sivashangar, Lallindra Gooneratne, Barnaby Clark, David Rees, Saroj Jayasinghe, Claire Laas   +5 more
doaj   +1 more source

Ethyl pyruvate protects SHSY5Y cells against 6-hydroxydopamine-induced neurotoxicity by upregulating autophagy

PLoS ONE, 2023
Parkinson disease is a chronic progressive neurodegenerative disorder with a prevalence that increases with age. The glycolytic end-product pyruvate, has antioxidant and neuroprotective feature. Here, we investigated the effects of ethyl pyruvate (EP), a
Yuening Luo, Kazuichi Sakamoto
doaj   +2 more sources

Suppressed “Warburg Effect” in Nasopharyngeal Carcinoma Via the Inhibition of Pyruvate Kinase Type M2-Mediated Energy Generation Pathway

Technology in Cancer Research & Treatment, 2020
Warburg effect describes the abnormal energy metabolism in cancer cells and pyruvate kinase type M2 is involved in the regulation of this effect.
Penglong Zhao MBBS, Mengyan Zhou MMed, Ruixiang Chen MBBS, Renjie Su MMed   +3 more
doaj   +1 more source