Results 21 to 30 of about 1,722,299 (336)

Suppressed “Warburg Effect” in Nasopharyngeal Carcinoma Via the Inhibition of Pyruvate Kinase Type M2-Mediated Energy Generation Pathway

Technology in Cancer Research & Treatment, 2020
Warburg effect describes the abnormal energy metabolism in cancer cells and pyruvate kinase type M2 is involved in the regulation of this effect.
Penglong Zhao MBBS, Mengyan Zhou MMed, Ruixiang Chen MBBS, Renjie Su MMed   +3 more
doaj   +1 more source

The Allosteric Regulation of Pyruvate Kinase [PDF]

Journal of Biological Chemistry, 2000
Pyruvate kinase (PK) is critical for the regulation of the glycolytic pathway. The regulatory properties of Escherichia coli were investigated by mutating six charged residues involved in interdomain salt bridges (Arg(271), Arg(292), Asp(297), and Lys(413)) and in the binding of the allosteric activator (Lys(382) and Arg(431)).
VALENTINI, GIOVANNA, CHIARELLI, LAURENT, SPERANZA, MARIA LUISA, GALIZZI, ALESSANDRO, MATTEVI, ANDREA, FORTIN R   +5 more
openaire   +4 more sources

Metabolic agents that enhance ATP can improve cognitive functioning: a review of the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine. [PDF]

, 2011
Over the past four or five decades, there has been increasing interest in the neurochemical regulation of cognition. This field received considerable attention in the 1980s, with the identification of possible cognition enhancing agents or "smart drugs".
Sünram-Lea, Sandra-Ilona, Owen, Lauren
core   +5 more sources

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.

Cell Metabolism, 2006
Activation of glycolytic genes by HIF-1 is considered critical for metabolic adaptation to hypoxia through increased conversion of glucose to pyruvate and subsequently to lactate.
Jung-whan Kim, Irina Tchernyshyov, G. Semenza, C. Dang   +3 more
semanticscholar   +1 more source

Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria. [PDF]

, 2012
BACKGROUND: Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far.
Cláudia Gomes (127952), Licínio Manco (127951), Cláudia Gomes, Juliana Miranda (127964), Sérgio Chibute, Cano, Jorge, Graça Salomé (127955), Miranda, Juliana, Cristina Mendes, Sitoe, Luis, Ribeiro, Letícia, Sérgio Chibute (127957), José Langa (127958), Ana Paula Arez (127971), Fernandes, Natércia, Graça Salomé, António Amorim (3284517), do Rosário, Virgílio E, Ana Paula Arez, do Rosário, Virgílio E., Langa, José, Juliana Miranda, Chibute, Sérgio, Letícia Ribeiro (127961), José Langa, Ochando, Jordi, Patrícia Machado, Patrícia Machado (127949), Gomes, Cláudia, Letícia Ribeiro, Arez, Ana Paula, Salomé, Graça, Machado, Patrícia, João Pinto (36645), Manco, Licínio, Pinto, João, Jorge Cano (37194), Mendes, Cristina, Amorim, António, Natércia Fernandes, Virgílio E do Rosário, António Amorim, Virgílio E. do Rosário (36653), João Pinto, Natércia Fernandes (127954), Cristina Mendes (127953), Licínio Manco, Luis Sitoe, Luis Sitoe (127956), Jorge Cano   +49 more
core   +1 more source

Ethyl pyruvate protects SHSY5Y cells against 6-hydroxydopamine-induced neurotoxicity by upregulating autophagy

PLoS ONE, 2023
Parkinson disease is a chronic progressive neurodegenerative disorder with a prevalence that increases with age. The glycolytic end-product pyruvate, has antioxidant and neuroprotective feature. Here, we investigated the effects of ethyl pyruvate (EP), a
Yuening Luo, Kazuichi Sakamoto
doaj   +2 more sources

DETECTION OF ENOLASE AND PYRUVATE KINASE ENZYMES FROM FLUORIDE SENSITIVE AND FLUORIDE RESISTANCE STREPTOCOCCUS MUTANS BY USING PCR. [PDF]

Journal of Bioscience and Applied Research
Background: This study aimed to detect enolase and pyruvate kinase, key metabolic enzymes in glycolysis, in fluoride-resistant and fluoride-sensitive Streptococcus mutans strains isolated from diabetic dental caries. Enolase catalyzes the conversion of 2-
Nuha Elhage, Sulieman El sanousi, Wafa Elhag   +2 more
doaj   +1 more source

Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly [PDF]

, 2011
Crucial to glucose homoeostasis in humans, the hPDC (human pyruvate dehydrogenase complex) is a massive molecular machine comprising multiple copies of three distinct enzymes (E1–E3) and an accessory subunit, E3BP (E3-binding protein). Its icosahedral E2/
Swetha Vijayakrishnan, Byron, Olwyn, Lindsay, J., Gilbert, David, Cooper, Alan, Lindsay, J.G., Nutley, Margaret A, Philip Callow, Byron, O., Callow, P, David Gilbert, Kropholler, P., Callow, Philip, Byron, O, McGow, D., Vijayakrishnan, S, David, Gilbert, Vijayakrishnan, Swetha, McGow, Donna P., Nutley, M.A., Gilbert, D, Callow, P., Kropholler, P, Alan Cooper, Nutley, Margaret A., Cooper, A., Donna P. McGow, Lindsay, J Gordon, Nutley, M., Lindsay, J. Gordon, Cooper, A, J. Gordon Lindsay, Vijayakrishnan, S., McGow, DP, Margaret A. Nutley, Olwyn Byron, Kropholler, Peter, Peter Kropholler, Mcgow, Donna P, Lindsay, JG, Nutley, MA, McGow, D.P., Gilbert, D.   +42 more
core   +1 more source

Malic Acid Production by Saccharomyces cerevisiae: Engineering of Pyruvate Carboxylation, Oxaloacetate Reduction, and Malate Export [PDF]

, 2008
Malic acid is a potential biomass-derivable "building block" for chemical synthesis. Since wild-type Saccharomyces cerevisiae strains produce only low levels of malate, metabolic engineering is required to achieve efficient malate production with this ...
Van Maris, A.J.A. (author), Dijkema, C., Van Winden, W.A. (author), Winden, W.A., van, Dijkema, C. (author), Zelle, R.M. (author), Van Maris, A.J.A., Van Winden, W.A., De Hulster, E., Geertman, J.M., Pronk, J.T. (author), Hulster, E., de, Geertman, J.M.A., Winkler, A.A. (author), Van Dijken, J.P., Pronk, J.T., Winkler, A.A., De Hulster, E. (author), De Waard, P. (author), Geertman, J.M. (author), Waard, P., de, Zelle, R.M., De Waard, P., Van Dijken, J.P. (author)   +23 more
core   +2 more sources

Transcriptional and Biochemical Characterization of Cytosolic Pyruvate Kinases in Arabidopsis thaliana

Plants, 2020
Glycolysis is a central catabolic pathway in every living organism with an essential role in carbohydrate breakdown and ATP synthesis, thereby providing pyruvate to the tricarboxylic acid cycle (TCA cycle).
Sabine Wulfert, Sören Schilasky, Stephan Krueger   +2 more
doaj   +1 more source