Results 11 to 20 of about 142,324 (262)
The Allosteric Regulation of Pyruvate Kinase [PDF]
Journal of Biological Chemistry, 2000 Pyruvate kinase (PK) is critical for the regulation of the glycolytic pathway. The regulatory properties of Escherichia coli were investigated by mutating six charged residues involved in interdomain salt bridges (Arg(271), Arg(292), Asp(297), and Lys(413)) and in the binding of the allosteric activator (Lys(382) and Arg(431)).
VALENTINI, GIOVANNA +5 more
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PLoS ONE, 2023 Parkinson disease is a chronic progressive neurodegenerative disorder with a prevalence that increases with age. The glycolytic end-product pyruvate, has antioxidant and neuroprotective feature. Here, we investigated the effects of ethyl pyruvate (EP), a
Yuening Luo, Kazuichi Sakamoto
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Crystal structure of Cryptosporidium parvum pyruvate kinase. [PDF]
PLoS ONE, 2012 Pyruvate kinase plays a critical role in cellular metabolism of glucose by serving as a major regulator of glycolysis. This tetrameric enzyme is allosterically regulated by different effector molecules, mainly phosphosugars.
William J Cook +3 more
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DETECTION OF ENOLASE AND PYRUVATE KINASE ENZYMES FROM FLUORIDE SENSITIVE AND FLUORIDE RESISTANCE STREPTOCOCCUS MUTANS BY USING PCR. [PDF]
Journal of Bioscience and Applied ResearchBackground: This study aimed to detect enolase and pyruvate kinase, key metabolic enzymes in glycolysis, in fluoride-resistant and fluoride-sensitive Streptococcus mutans strains isolated from diabetic dental caries. Enolase catalyzes the conversion of 2-
Nuha Elhage +2 more
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Plants, 2020 Glycolysis is a central catabolic pathway in every living organism with an essential role in carbohydrate breakdown and ATP synthesis, thereby providing pyruvate to the tricarboxylic acid cycle (TCA cycle).
Sabine Wulfert +2 more
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Frontiers in Physiology, 2020 A metabolic hallmark of many cancers is the increase in glucose consumption coupled to excessive lactate production. Mindful that L-lactate originates only from pyruvate, the question arises as to how can this be sustained in those tissues where pyruvate
Christos Chinopoulos
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Rapid inhibition of pyruvate dehydrogenase: an initiating event in high dietary fat-induced loss of metabolic flexibility in the heart. [PDF]
PLoS ONE, 2013 Cardiac function depends on the ability to switch between fatty acid and glucose oxidation for energy production in response to changes in substrate availability and energetic stress.
Clair Crewe +2 more
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Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis
Frontiers in Oncology, 2020 Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. There are four isomeric, tissue-specific
Kulsoom Zahra +4 more
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Pyruvate Kinase Deficiency Causing Priapism
Case Reports in Hematology, 2023 Pyruvate kinase deficiency (PKD) is an autosomal recessive defect of the enzyme pyruvate kinase (PK) which is involved in catalyzing a reaction that produces ATP in the glycolytic pathway. It is the most common defect of the glycolytic pathway associated
Vinay Hanyalu Shankar +6 more
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Specificity of pyruvate kinase [PDF]
Biochimica et Biophysica Acta, 1959 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/32459/1/0000543 ...
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