Results 11 to 20 of about 1,722,299 (336)
Crystal structure of Cryptosporidium parvum pyruvate kinase. [PDF]
PLoS ONE, 2012 Pyruvate kinase plays a critical role in cellular metabolism of glucose by serving as a major regulator of glycolysis. This tetrameric enzyme is allosterically regulated by different effector molecules, mainly phosphosugars.
William J Cook +3 more
doaj +2 more sources
Effects of Pyruvate Kinase Phosphorylation and Acetylation on Its Activity and Structure
Shipin gongye ke-jiPyruvate kinase is one of the important glycolytic enzymes that affects the rate of postmortem muscle glycolysis and then regulates meat quality.
Xiaolan HUANG +7 more
doaj +2 more sources
Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma. [PDF]
PLoS ONE, 2013 Normal tissues express the M1 isoform of pyruvate kinase (PK) that helps generate and funnel pyruvate into the mitochondria for ATP production. Tumors, in contrast, express the less active PKM2 isoform, which limits pyruvate production and spares ...
Joydeep Mukherjee +5 more
doaj +2 more sources
Metabolite analysis of Escherichia coli in response to changes in oxygen levels [PDF]
, 2013 E. coli is a versatile bacterium that has three metabolic modes: aerobic, anaerobic and fermentation. The major environmental factor that controls the switching between these metabolic modes is oxygen availability. E.
Yasid, Nur Adeela
core +6 more sources
Diagnostic value of plasma M2-pyruvate kinase in Egyptian patients with colorectal cancer [PDF]
Al-Azhar International Medical Journal, 2022 Background: M2-pyruvate kinase (M2-PK) plays an important role in tumor metabolism, and new studies have shown that M2-PK can operate as both a protein kinase and a transcription factor coactivator.
Islam Ghoniem +4 more
doaj +1 more source
Journal of Clinical Investigation, 2021 Anemia in β-thalassemia is related to ineffective erythropoiesis and reduced red cell survival. Excess free heme and accumulation of unpaired α-globin chains impose substantial oxidative stress on β-thalassemic erythroblasts and erythrocytes, impacting ...
A. Matte +23 more
semanticscholar +1 more source
Journal of physiology and biochemistry, 2021 PKM2, pyruvate kinase type M2, has been shown to play a key role in aerobic glycolysis and to regulate the malignant behaviors of cancer cells. Recently, PKM2 has been revealed to hold dual metabolic and nonmetabolic roles.
Shu-Tao Zheng +3 more
semanticscholar +1 more source
Research Advances in Plant Pyruvate Kinase. [PDF]
Int J Mol SciPyruvate kinase (PK) is the terminal rate-limiting enzyme of glycolysis and occupies a central position in plant energy metabolism and carbon skeleton allocation. Plant PK isoenzymes comprise the cytosolic pyruvate kinase (PKc) and the plastidic pyruvate
Peng R +7 more
europepmc +2 more sources
Journal of Medical Case Reports, 2021 Background Erythrocyte pyruvate kinase is expressed under the control of the PKLR gene located on chromosome 1q21. Pyruvate kinase catalyzes the final steps of the glycolytic pathway and creates 50% of the red cell total adenosine triphosphate.
Ahalyaa Sivashangar +5 more
doaj +1 more source
Pyruvate kinase phosphatase [PDF]
FEBS Letters, 1981 1. Introduction Liver pyruvate kinase can be phosphorylated and simultaneously inactivated by CAMP-dependent pro- tein kinase; the inactivated enzyme can be reactivated by a multifunctional protein phosphatase (review [ 13). The inactivation of pyruvate kinase has been observed in isolated hepatocytes incubated in the presence of glucagon and in this ...
Jett, Mary-Frances +2 more
openaire +2 more sources