Crystal structure of Cryptosporidium parvum pyruvate kinase. [PDF]
PLoS ONE, 2012 Pyruvate kinase plays a critical role in cellular metabolism of glucose by serving as a major regulator of glycolysis. This tetrameric enzyme is allosterically regulated by different effector molecules, mainly phosphosugars.
William J Cook +3 more
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Effects of Pyruvate Kinase Phosphorylation and Acetylation on Its Activity and Structure
Shipin gongye ke-jiPyruvate kinase is one of the important glycolytic enzymes that affects the rate of postmortem muscle glycolysis and then regulates meat quality.
Xiaolan HUANG +7 more
doaj +2 more sources
Is it possible for pyruvate kinase to be a non-small cell lung cancer marker? [PDF]
Family Medicine & Primary Care Review, 2016 Background . Lung cancer is the most common cause of morbidity and mortality among all cancers. The dominant type of lung cancer is non-small cell lung cancer.
Aleksandra Kamińska +2 more
doaj +2 more sources
Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma. [PDF]
PLoS ONE, 2013 Normal tissues express the M1 isoform of pyruvate kinase (PK) that helps generate and funnel pyruvate into the mitochondria for ATP production. Tumors, in contrast, express the less active PKM2 isoform, which limits pyruvate production and spares ...
Joydeep Mukherjee +5 more
doaj +2 more sources
Mitapivat versus Placebo for Pyruvate Kinase Deficiency.
, 2022 20.500.12530/87857Pyruvate kinase deficiency is a rare, hereditary, chronic condition that is associated with hemolytic anemia. In a phase 2 study, mitapivat, an oral, first-in-class activator of erythrocyte pyruvate kinase, increased the hemoglobin ...
Verhovsek, Madeleine +19 more
core +3 more sources
PLoS ONE, 2023 Parkinson disease is a chronic progressive neurodegenerative disorder with a prevalence that increases with age. The glycolytic end-product pyruvate, has antioxidant and neuroprotective feature. Here, we investigated the effects of ethyl pyruvate (EP), a
Yuening Luo, Kazuichi Sakamoto
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Protein kinase function of pyruvate kinase M2 and cancer
Cancer Cell International, 2020 Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation.
Xun Chen, Shangwu Chen, Dongsheng Yu
doaj +1 more source
The Allosteric Regulation of Pyruvate Kinase [PDF]
Journal of Biological Chemistry, 2000 Pyruvate kinase (PK) is critical for the regulation of the glycolytic pathway. The regulatory properties of Escherichia coli were investigated by mutating six charged residues involved in interdomain salt bridges (Arg(271), Arg(292), Asp(297), and Lys(413)) and in the binding of the allosteric activator (Lys(382) and Arg(431)).
VALENTINI, GIOVANNA +5 more
openaire +4 more sources
Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria. [PDF]
, 2012 BACKGROUND: Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far.
Cláudia Gomes (127952) +49 more
core +1 more source
DETECTION OF ENOLASE AND PYRUVATE KINASE ENZYMES FROM FLUORIDE SENSITIVE AND FLUORIDE RESISTANCE STREPTOCOCCUS MUTANS BY USING PCR. [PDF]
Journal of Bioscience and Applied ResearchBackground: This study aimed to detect enolase and pyruvate kinase, key metabolic enzymes in glycolysis, in fluoride-resistant and fluoride-sensitive Streptococcus mutans strains isolated from diabetic dental caries. Enolase catalyzes the conversion of 2-
Nuha Elhage +2 more
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