Results 21 to 30 of about 2,701 (230)

Lactate oxidation at the mitochondria: a lactate-malate-aspartate shuttle at work

Frontiers in Neuroscience, 2014
Lactate, the conjugate base of lactic acid occurring in aqueous biological fluids, has been derided as a dead-end waste product of anaerobic metabolism.
Daniel A Kane
doaj   +1 more source

Synthesis, characterization and thermal behaviour on solid pyruvates of light trivalent lanthanides

Eclética Química, 2018
Solid State Ln-L compounds, where Ln stands for light trivalent lanthanides (La – Gd) and L is pyruvate, have been synthesized. Thermogravimetry and derivative thermo- gravimetry (TG/DTG), differential scanning calorimetry (DSC), X-Ray powder ...
A. B. Siqueira, C. T. de Carvalho, Érica Alvarenga Crespo Rodrigues, Elias Y. Ionashiro, Gilbert Bannach, Massao Ionashiro   +5 more
doaj   +1 more source

Copper-catalyzed asymmetric methylation of fluoroalkylated pyruvates with dimethylzinc

Beilstein Journal of Organic Chemistry, 2018
The catalytic asymmetric methylation of fluoroalkylated pyruvates is shown with dimethylzinc as a methylating reagent in the presence of a copper catalyst bearing a chiral phosphine ligand. This is the first catalytic asymmetric methylation to synthesize
Kohsuke Aikawa, Kohei Yabuuchi, Kota Torii, Koichi Mikami   +3 more
doaj   +1 more source

Synthesis, characterization and thermal behaviour on solid pyruvates of some bivalent metal ions.

Eclética Química, 2018
Solid state M-L compounds, were M stands for bivalent Mn, Fe, Co, Ni, Cu, Zn and L is pyruvate, have been synthesized. Thermogravimetry and derivative thermogravimetry (TG/DTG), differential scanning calorimetry (DSC), X-Ray powder diffractometry ...
Adriano Buzutti de Siqueira, Cláudio Teodoro de Carvalho, Elias Yuki Ionashiro, Massao Ionashiro   +3 more
doaj   +1 more source

ANTICANCER POTENTIAL OF NOVEL PALLADIUM(II) COMPLEXES WITH ACYL PYRUVATES AS LIGANDS: DNA AND BSA INTERACTIONS AND MOLECULAR DOCKING STUDY [PDF]

STED Journal
Bearing in mind that some palladium complexes showed good antitumor potential while exhibiting less kidney toxicity comparing to cisplatin, to discover a new agents for chemotherapy with improved properties two novel palladium(II) complexes [Pd (L)2] (3A
Nenad Joksimović, Jelena Petronijević, Marina Serafinović, Nenad Janković, Dejan Baskic   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Effect of dexamethasone on gluconeogenesis, pyruvate kinase, pyruvate carboxylase and pyruvate dehydrogenase flux in isolated hepatocytes [PDF]

Biochemical Journal, 1993
Treatment of 18 h-starved rats with dexamethasone and subsequent isolation and incubation of the hepatocytes in the presence of the steroid increased gluconeogenic flux with both 1.0 mM pyruvate and 1.0 mM lactate plus 0.2 mM pyruvate as the substrate. The magnitude of stimulation was comparable with both substrates.
C G, Jones, S K, Hothi, M A, Titheradge
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source