Results 1 to 10 of about 381,611 (334)
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Conjugation of drugs with biotin is a widely studied strategy for targeted drug delivery. The structure–activity relationship (SAR) studies through H3-biotin competition experiments conclude with the presence of a free carboxylic acid being essential for
Ravi Tripathi +2 more
exaly +4 more sources
BioFactors, 2009 AbstractBiotin is a water‐soluble vitamin and serves as a coenzyme for five carboxylases in humans. Biotin is also covalently attached to distinct lysine residues in histones, affecting chromatin structure and mediating gene regulation. This review describes mammalian biotin metabolism, biotin analysis, markers of biotin status, and biological ...
János Zempléni +1 more
exaly +5 more sources
Biotin, a universal and essential cofactor: synthesis, ligation and regulation
FEMS Microbiology Reviews, 2021 Biotin is a covalently attached enzyme cofactor required for intermediary metabolism in all three domains of life. Several important human pathogens (e.g. Mycobacterium tuberculosis) require biotin synthesis for pathogenesis.
John E Cronan, Chaiyos Sirithanakorn
exaly +2 more sources
Best practices in mitigating the risk of biotin interference with laboratory testing
Clinical Biochemistry, 2019 Dietary biotin intake does not typically result in blood biotin concentrations that exceed interference thresholds for in vitro diagnostic tests. However, recent trends of high-dose biotin supplements and clinical trials of very high biotin doses for ...
Alagarraju Muthukumar +2 more
exaly +2 more sources
Annals of Agricultural Sciences, 2021 Melinjo (Gnetum gnemon L.) is a beneficial agroforestry plant that contains antioxidant compounds broadly studied as a natural source in pharmaceutical and nutraceutical uses.
Tri Agus Siswoyo +3 more
doaj +1 more source
Chlorin e6-Biotin Conjugates for Tumor-Targeting Photodynamic Therapy
Molecules, 2021 To improve the tumor-targeting efficacy of photodynamic therapy, biotin was conjugated with chlorin e6 to develop a new tumor-targeting photosensitizer, Ce6-biotin. The Ce6-biotin had good water solubility and low aggregation.
Wei Liu +7 more
doaj +1 more source
Current Issues in Molecular Biology, 2023 An immunoassay is an analytical test method in which analyte quantitation is based on signal responses generated as a consequence of an antibody–antigen interaction. They are the method of choice for the measurement of a large panel of diagnostic markers.
Amy H. A. Balzer +1 more
semanticscholar +1 more source
Gut, 2022 Objectives Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome’s functional composition in healthy metabolic state and the most ...
Eugeni Belda +61 more
semanticscholar +1 more source
Biotin's Lessons in Drug Design.
Journal of Medicinal Chemistry, 2021 At the heart of drug design is the discovery of molecules that bind with high affinity to their drug targets. Biotin forms the strongest known noncovalent ligand-protein interactions with avidin and streptavidin, achieving femtomolar and picomolar ...
D. McConnell
semanticscholar +1 more source
Ligand specificity of group I biotin protein ligase of Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2008 BACKGROUND: Fatty acids are indispensable constituents of mycolic acids that impart toughness & permeability barrier to the cell envelope of M. tuberculosis.
Sudha Purushothaman +4 more
doaj +1 more source