Results 11 to 20 of about 381,611 (334)

Characterization of the biotin uptake system encoded by the biotin-inducible bioYMN operon of Corynebacterium glutamicum [PDF]

BMC Microbiology, 2012
Background The amino acid-producing Gram-positive Corynebacterium glutamicum is auxotrophic for biotin although biotin ring assembly starting from the precursor pimeloyl-CoA is still functional.
Schneider Jens, Peters-Wendisch Petra, Stansen K Corinna, Götker Susanne, Maximow Stanislav, Krämer Reinhard, Wendisch Volker F   +6 more
doaj   +2 more sources

Biotin-mediated drug delivery: does the biotin transporter mediate uptake of biotin conjugates?

Journal of Enzyme Inhibition and Medicinal Chemistry
Sodium-dependent multivitamin transporter (SMVT) is a biotin transporter over-expressed in various types of cancer cells and is commonly studied for targeted drug delivery using biotin conjugates.
Ravi Tripathi, Xiaoxiao Yang, Dongning Liu, Wen Lu, Binghe Wang   +4 more
doaj   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish. [PDF]

FEBS Open Bio
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Saralahti AK, Ojanen MJT, Parikka M, Kauko O, Rämet M, Hytönen VP.   +5 more
europepmc   +2 more sources

Discovery of Novel d‑(+)-Biotin-Conjugated Resorcinol Dibenzyl Ether-Based PD-L1 Inhibitors for Targeted Cancer Immunotherapy

, 2023
In this work, we rationally designed, synthesized, and evaluated a series of novel d-(+)-biotin-conjugated PD-L1 inhibitors for targeted cancer therapy. Among them, SWS1 exhibited the highest anti-PD-1/PD-L1 activity with an IC50 of 1.8 nM.
Xiaoting Fei (16634108), Zongbao Ding (13817473), Yaru Shi (2497831), Yiyu Lu (403998), Shuanghu Wang (7511795), Binbin Cheng (9187351), Jianjun Chen (38177)   +6 more
core   +4 more sources

The Development and Evaluation of Novel Reagents for Pre-Targeted Radioimmunotherapy [PDF]

, 2004
PhDIn a pretargeting radioimmunotherapy system, monoclonal antibodies (MAbs) derivatised with a high affinity streptavidin receptor are used in a localisation step.
Hainsworth, James Edward Scott
core   +4 more sources

Biotinylated Quinone as a Chemiluminescence Sensor for Biotin-Avidin Interaction and Biotin Detection Application

Sensors, 2023
Biotin, or vitamin B7, is essential for metabolic reactions. It must be obtained from external sources such as food and biotin/vitamin supplements because it is not biosynthesized by mammals.
Fatema Kaladari, Mahmoud El-Maghrabey, Megumi Kawazato, Naoya Kishikawa, Naotaka Kuroda   +4 more
doaj   +1 more source

Biotin: From Nutrition to Therapeutics

Journal of Nutrition, 2017
Donald M Mock
exaly   +2 more sources

Studies on the biosynthesis of biotin. Production of biotin and biotin-like compounds by a pseudomonad [PDF]

Biochemical Journal, 1965
1. Filtrates from cultures of a strain of Pseudomonas aeruginosa, grown in a basal glucose-ammonium chloride-vitamins-salts medium, possessed biotin activity as detected by microbiological assays. Exponential-phase culture filtrates contained biotin and desthiobiotin in the approximate ratio 1:3, with smaller amounts of biotin sulphoxide and three ...
A H, Rose, M, Ilahi, M V, Kelemen
openaire   +2 more sources

Graphene field-effect transistor biosensor for detection of biotin with ultrahigh sensitivity and specificity

Biosensors & bioelectronics, 2020
Because avidin and biotin molecules exhibit the most specific and strongest non-covalent interaction, avidin-biotin technology is widely used in ELISA (enzyme-linked immunosorbent assay) kits for the detection of different bio-macromolecules linked to ...
Shiyu Wang, M. Hossain, K. Shinozuka, Natsuhiko Shimizu, Shunya Kitada, Takaaki Suzuki, Ryo Ichige, A. Kuwana, H. Kobayashi   +8 more
semanticscholar   +1 more source

Impaired biotin status in anticonvulsant therapy [PDF]

, 1982
In 264 epileptics undergoing long-term therapy with anticonvulsants, significantly reduced plasma biotin levels were found compared with a normal control group: 74% of the epileptics had biotin levels for those treated with sodium valproate were higher ...
Krause, Klaus-Henning, Bonjour, Jean-Pierre, Berlit, Peter   +2 more
core   +1 more source