Results 11 to 20 of about 92,949 (326)

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small cell lung cancer in preclinical models [PDF]

Nature Medicine, 2016
Continuous de novo fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an attractive but ...
R. Svensson, Seth J. Parker, Lillian J. Eichner, Matthew J. Kolar, M. Wallace, Sonja N. Brun, P. S. Lombardo, Jeanine L Van Nostrand, Amanda Hutchins, L. Vera, Laurie Gerken, J. Greenwood, Sathesh Bhat, G. Harriman, W. Westlin, H. J. Harwood, A. Saghatelian, R. Kapeller, Christian M. Metallo, R. Shaw   +19 more
semanticscholar   +5 more sources

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.

Cell Metabolism, 2019
The incidence of hepatocellular carcinoma (HCC) is rapidly increasing due to the prevalence of obesity and non-alcoholic fatty liver disease, but the molecular triggers that initiate disease development are not fully understood.
J. Lally, Sarani Ghoshal, D. DePeralta, O. Moaven, Lan Wei, Ricard Masia, Derek J. Erstad, N. Fujiwara, Vivian Leong, Vanessa P. Houde, Alexander E. Anagnostopoulos, Alice Wang, Lindsay A. Broadfield, R. Ford, R. Foster, J. Bates, H. Sun, Ting Wang, Henry Liu, A. Ray, A. Saha, J. Greenwood, Sathesh Bhat, G. Harriman, Wenyan Miao, J. Rocnik, W. Westlin, P. Muti, T. Tsakiridis, H. J. Harwood, R. Kapeller, Y. Hoshida, K. Tanabe, G. Steinberg, B. Fuchs   +34 more
semanticscholar   +3 more sources

Alternative polyadenylation regulates acetyl-CoA carboxylase function in peanut [PDF]

BMC Genomics, 2023
Background Polyadenylation is a crucial process that terminates mRNA molecules at their 3′-ends. It has been observed that alternative polyadenylation (APA) can generate multiple transcripts from a single gene locus, each with different polyadenylation ...
Zhenying Peng, Shuang Yu, Jingjing Meng, Kai-Hua Jia, Jialei Zhang, Xinguo Li, Wenwei Gao, Shubo Wan   +7 more
doaj   +2 more sources

Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation.

Journal of Hepatology, 2020
BACKGROUND & AIMS Nonalcoholic steatohepatitis (NASH) is a chronic liver disease characterized by hepatic lipid accumulation, inflammation, and progressive fibrosis. Acetyl-CoA carboxylase (ACC) catalyzes the rate-limiting step of de novo lipogenesis and
J. Bates, A. Vijayakumar, Sarani Ghoshal, B. Marchand, Saili Yi, D. Kornyeyev, A. Zagórska, D. Hollenback, Katie Walker, Kathy Liu, Swetha Pendem, D. Newstrom, R. Brockett, I. Mikaelian, Saritha Kusam, Ricardo Ramírez, David Lopez, Li Li, B. Fuchs, D. Breckenridge   +19 more
semanticscholar   +3 more sources

Plant acetyl-CoA carboxylase: The homomeric form and the heteromeric form [PDF]

BBA Advances
Across the domains of life, the enzyme acetyl-CoA carboxylase (ACC) converts HCO3−, ATP, and acetyl-CoA to malonyl-CoA, ADP, and Pi. Malonyl-CoA is the building block for all de novo fatty acid biosynthesis.
Dilawar Niazi, Greg B.G. Moorhead
doaj   +2 more sources

Platelet Acetyl-CoA Carboxylase Phosphorylation

JACC: Basic to Translational Science, 2019
Summary: Adenosine monophosphate–activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway.
Shakeel Kautbally, MD, Sophie Lepropre, PhD, Marie-Blanche Onselaer, PhD, Astrid Le Rigoleur, MD, Audrey Ginion, MS, Christophe De Meester de Ravenstein, PhD, Jerome Ambroise, PhD, Karim Z. Boudjeltia, PhD, Marie Octave, MS, Odile Wéra, MS, Alexandre Hego, BSc, Joël Pincemail, PhD, Jean-Paul Cheramy-Bien, Thierry Huby, PhD, Martin Giera, PhD, Bernhard Gerber, MD, PhD, Anne-Catherine Pouleur, MD, PhD, Bruno Guigas, PhD, Jean-Louis Vanoverschelde, MD, PhD, Joelle Kefer, MD, PhD, Luc Bertrand, PhD, Cécile Oury, PhD, Sandrine Horman, PhD, Christophe Beauloye, MD, PhD   +23 more
doaj   +2 more sources

High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5′-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase (*)

Journal of Biological Chemistry, 1995
We determined whether high fatty acid oxidation rates during aerobic reperfusion of ischemic hearts could be explained by a decrease in malonyl-CoA levels, which would relieve inhibition of carnitine palmitoyltransferase 1, the rate-limiting enzyme ...
Naomi Kudo, A. Barr, R. Barr, Snehal Desai, G. Lopaschuk   +4 more
semanticscholar   +2 more sources

Acetyl-CoA carboxylase maintains energetic balance for functional oogenesis [PDF]

Nature Communications
Reproduction is tightly linked to nutrient availability and metabolic homeostasis, yet how specific metabolic pathways coordinate with cellular signaling to control oogenesis remains unclear.
Oyundari Amartuvshin, Chi-Hung Lin, Yi-Ting Ke, Han-Jung Lee, Kreeti Kajal, Tsai-Ling Huang, Wen-Der Wang, Tsai-Ming Lu, Ling-Huei Yih, Chen-Yuan Tseng, Hwei-Jan Hsu   +10 more
doaj   +2 more sources

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance Using structure-based drug design, we have identified a series of potent allosteric protein–protein interaction acetyl-CoA carboxylase inhibitors, exemplified by ND-630, that interact within the acetyl-CoA carboxylase subunit phosphopeptide ...
G. Harriman, J. Greenwood, Sathesh Bhat, Xinyi Huang, Ruiying Wang, D. Paul, L. Tong, A. Saha, W. Westlin, R. Kapeller, H. J. Harwood   +10 more
semanticscholar   +3 more sources

The Classical, Yet Controversial, First Enzyme of Lipid Synthesis: Escherichia coli Acetyl-CoA Carboxylase

Microbiology and Molecular Biology Reviews, 2021
Escherichia coli acetyl-CoA carboxylase (ACC), the enzyme responsible for synthesis of the malonyl-CoA, the building block of fatty acid synthesis, is the paradigm bacterial ACC.
J. Cronan
semanticscholar   +3 more sources