Results 1 to 10 of about 176,579 (332)

E3 ubiquitin ligases: styles, structures and functions

Molecular Biomedicine, 2021
E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2.
Quan Yang, Jinyao Zhao, Dan Chen, Yang Wang   +3 more
doaj   +2 more sources

The roles of E3 ubiquitin ligases in cancer progression and targeted therapy

Clinical and Translational Medicine, 2023
Ubiquitination is one of the most important post‐translational modifications which plays a significant role in conserving the homeostasis of cellular proteins.
Chibuzo Sampson, Qiuping Wang, Wuxiyar Otkur, Haifeng Zhao, Yun Lu, Xiaolong Liu, Hai‐long Piao   +6 more
doaj   +2 more sources

E3 ubiquitin ligases: structural diversity, dysregulation in disease, and their emerging role in targeted therapeutic strategies [PDF]

Frontiers in Molecular Biosciences
The Ubiquitin-Proteasome System (UPS) is a key mechanism of cellular homeostasis. A central part of this mechanism is E3 ubiquitin ligases, which selectively direct proteins to be ubiquitinated for degradation via the UPS.
Srineevas Sriram, Prahalad Krishnakumar, C. Sudandiradoss   +2 more
doaj   +2 more sources

E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy [PDF]

MedComm
E3 ubiquitin ligases are pivotal regulators within the ubiquitin–proteasome system, conferring specificity to protein ubiquitination and subsequent degradation, thereby maintaining cellular homeostasis.
Haochen Wang, Junbo Peng, Hongchan Li, Yuzhe Lan, Jing Guo, Qiang Qiu, Xuan Huang   +6 more
doaj   +2 more sources

MAGE-A cancer/testis antigens inhibit MDM2 ubiquitylation function and promote increased levels of MDM4 [PDF]

, 2015
Melanoma antigen A (MAGE-A) proteins comprise a structurally and biochemically similar sub-family of Cancer/Testis antigens that are expressed in many cancer types and are thought to contribute actively to malignancy.
A Gembarska, A Shvarts, AJ Simpson, AK Hock, Alastair M. Thompson, AM Carrillo, B Yang, Bianca Ihrig, C Blattner, CF Cheok, Chunhong Yan, D Xirodimas, David W. Meek, DW Meek, EB Askew, EB Askew, EM Wilson, H Kawai, IM Love, J Shloush, JA Barboza, JM Doyle, John Hourihan, K Linke, KC Espantman, KH Vousden, L Burch, L Huang, L Marcar, Lee B. Jordan, LT Vassilev, LY Peche, Lynnette Marcar, M Kostic, M Monte, M Sang, M Wade, M Wade, MJ Scanlan, MJ Scanlan, MV Poyurovsky, P Chomez, P de Graaf, P van der Bruggen, PH Kussie, Philip R. Quinlan, PP Wong, R Kulikov, S Detre, S Kurki, S Laduron, S Uldrijan, SI King, SM Hadad, Susan E. Bray, T Nardiello, Ted R. Hupp, TZ Xiao, V Pant, W Hu, W Liu, X Wang, Y Feng, Y Pan   +63 more
core   +18 more sources

E3 ubiquitin ligases in the acute leukemic signaling pathways

Frontiers in Physiology, 2022
Acute leukemia is a common hematologic tumor with highly genetic heterogeneity, and many factors are involved in the pathogenesis and drug-resistance mechanism.
Qianru Zhan, Heyang Zhang, Boquan Wu, Naijin Zhang, Lijun Zhang   +4 more
doaj   +1 more source

From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease

Cells, 2022
The ubiquitin–proteasome system is of fundamental importance in all fields of biology due to its impact on proteostasis and in regulating cellular processes.
Valérie C. Cabana, Marc P. Lussier
doaj   +1 more source

The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy

Frontiers in Immunology, 2023
Bladder cancer is one of the common malignant urothelial tumors. Post-translational modification (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation, have been revealed to participate in bladder cancer initiation and ...
Xuemei Wang, Ying Zhang, Yao Wu, Hongjing Cheng, Xueju Wang   +4 more
doaj   +1 more source

The involvement of E3 ubiquitin ligases in the development and progression of colorectal cancer

Cell Death Discovery, 2023
To date, colorectal cancer (CRC) still has limited therapeutic efficacy and poor prognosis and there is an urgent need for novel targets to improve the outcome of CRC patients.
Jie Chen, Haimei Feng, Yiting Wang, Xiaoming Bai, Siqi Sheng, Huiyu Li, Mengxi Huang, Xiaoyuan Chu, Zengjie Lei   +8 more
doaj   +1 more source

Comprehensive analysis of the expression and prognosis for RBR E3 ubiquitin ligases in lung adenocarcinoma

Thoracic Cancer, 2022
Background Lung adenocarcinoma (LUAD) is the most common subtype of non‐small cell lung cancer and has a poor prognosis. RBR E3 ubiquitin ligases are a special class of E3 ubiquitin ligases which contain three zinc‐bing domains that catalyze ubiquitin to
Hao Ding, Yuxin Wang, Yuan Cui, Zhike Chen, Yu Li, Jian Yang, Yang Yang, Tengfei Chen, Dian Xia, Chang Li, Chun Xu, Cheng Ding, Jun Zhao   +12 more
doaj   +1 more source