Expanding PROTACtable genome universe of E3 ligases [PDF]
Nature Communications, 2023 Proteolysis-targeting chimera (PROTAC) and other targeted protein degradation (TPD) molecules that induce degradation by the ubiquitin-proteasome system (UPS) offer new opportunities to engage targets that remain challenging to be inhibited by ...
Yubin Zhou, Luo Mei, Zeev Ronai
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Advances of E3 ligases in lung cancer [PDF]
Biochemistry and Biophysics ReportsLung cancer is a leading cause of cancer-related death, and the most common type of lung cancer is non-small cell lung cancer, which accounts for approximately 85 % of lung cancer diagnoses.
Jingwen Yu, Yiqi Zhao, Yue Xie
doaj +4 more sources
E3 ubiquitin ligases: styles, structures and functions
Molecular Biomedicine, 2021 E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2.
Yang Wang, Jinyao Zhao, Zhao Jinyao
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The roles of E3 ubiquitin ligases in cancer progression and targeted therapy
Clinical and Translational Medicine, 2023 Ubiquitination is one of the most important post‐translational modifications which plays a significant role in conserving the homeostasis of cellular proteins.
Hai-Long Piao, Xiaolong Liu
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The enigma of the RING-UIM E3 ligases: its transformative impact on cancer research [PDF]
Journal of Translational MedicineRING-UIM E3 ligases, a subfamily within the RING-type E3 ligases, comprise four members: RNF114, RNF125, RNF138, and RNF166. These ligases are crucial in various biological processes, including immunity, inflammation, epigenetics, and homologous ...
Ye Wang, Yue Zhao, Qi Xin, Jihong Zhang
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Ubiquitination mediated by RING-type E3 ligases in the progression of digestive system tumors: mechanistic insights and potential therapeutic strategies [PDF]
Frontiers in Cell and Developmental BiologyUbiquitination is a core mechanism for the precise regulation of protein fate, closely related to the occurrence and development of many diseases. As the most critical enzymes in the ubiquitination process, really interesting new gene (RING)-type E3 ...
Yuwei Wu +3 more
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E3 Ubiquitin Ligases as Cancer Targets and Biomarkers
Neoplasia, 2006 E3 ubiquitin ligases are a large family of proteins that are engaged in the regulation of the turnover and activity of many target proteins. Together with ubiquitinactivating enzyme El and ubiquitin-conjugating enzyme E2, E3 ubiquitin ligases catalyze ...
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BioE3 identifies specific substrates of ubiquitin E3 ligases [PDF]
Nature Communications, 2023 Hundreds of E3 ligases play a critical role in recognizing specific substrates for modification by ubiquitin (Ub). Separating genuine targets of E3s from E3-interactors remains a challenge. We present BioE3, a powerful approach for matching substrates to
Orhi Barroso-Gomila +14 more
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Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators [PDF]
Advanced ScienceE3 ligases are key regulators of the ubiquitin‐proteasome system (UPS) and have emerged as attractive drug target candidates for precise therapeutic intervention.
Míriam Martínez‐Cartró +13 more
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E3 ubiquitin ligases in the acute leukemic signaling pathways
Frontiers in Physiology, 2022 Acute leukemia is a common hematologic tumor with highly genetic heterogeneity, and many factors are involved in the pathogenesis and drug-resistance mechanism.
Qianru Zhan +4 more
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