Cereblon versus VHL: Hijacking E3 Ligases Against Each Other Using PROTACs [PDF]
, 2019 The von Hippel-Lindau (VHL) and cereblon (CRBN) proteins are substrate recognition subunits of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes.
Chiara, Maniaci +4 more
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Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons [PDF]
, 2021 The SUMOylation machinery is a regulator of neuronal activity and synaptic plasticity. It is composed of SUMO isoforms and specialized enzymes named E1, E2 and E3 SUMO ligases.
Colnaghi L. +9 more
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The Role of HECT E3 Ubiquitin Ligases in Colorectal Cancer
Biomedicines, 2023 Colorectal cancer (CRC) is estimated to rank as the second reason for cancer-related deaths, and the prognosis of CRC patients remains unsatisfactory. Numerous studies on gastrointestinal cell biology have shown that the E3 ligase-mediated ubiquitination
Aiqin Sun +3 more
doaj +1 more source
The E3 Ligases in Cervical Cancer and Endometrial Cancer [PDF]
, 2022 Endometrial (EC) and cervical (CC) cancers are the most prevalent malignancies of the female reproductive system. There is a global trend towards increasing incidence and mortality, with a decreasing age trend.
Fengguang Zhai +9 more
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Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation
, 2022 S.1014-1031Efficacy and selectivity of molecules inducing protein degradation depend on their affinity to the target protein but also on the type of E3 ubiquitin ligase that is recruited to trigger proteasomal degradation.
Dikic, I., Kannt, A.
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Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control
Molecules, 2021 Skeletal muscle loss is a detrimental side-effect of numerous chronic diseases that dramatically increases mortality and morbidity. The alteration of protein homeostasis is generally due to increased protein breakdown while, protein synthesis may also be
Dulce Peris-Moreno +4 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2022 Protein ubiquitination plays a vital role in controlling the degradation of intracellular proteins and in regulating cell signaling pathways. Functionally, E3 ubiquitin ligases control the transfer of ubiquitin to the target substrates. As a major family
Xiaohua Lou +7 more
doaj +1 more source
Biallelic variants in HECT E3 paralogs, HECTD4 and UBE3C, encoding ubiquitin ligases cause neurodevelopmental disorders that overlap with Angelman syndrome [PDF]
, 2022 Pathogenic variants in genes encoding ubiquitin E3 ligases are known to cause neurodevelopmental syndromes. Additional neurodevelopmental disorders associated with the other genes encoding E3 ligases are yet to be ...
Colin, Estelle +73 more
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Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA
Frontiers in Plant Science, 2021 Protein modification by the small ubiquitin-like modifier (SUMO) plays an important role in multiple plant processes, including growth, development, and the response to abiotic stresses.
Souleimen Jmii, Laurent Cappadocia
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Ligandability of E3 Ligases for Targeted Protein Degradation Applications
, 2021 Targeted protein degradation (TPD) using proteolysis targeting chimeras (PROTACs) and molecular glue degraders has arisen as a powerful therapeutic modality for eliminating disease-causing proteins from cells.
Daniel K. Nomura (198023) +2 more
core +3 more sources