Results 1 to 10 of about 7,347 (70)

DesignMaster: A Multi-Conditional Diffusion Framework for Rational PROTAC Design. [PDF]

Bioinformatics
Shi B, Hao Y, Liu J, Pan T, Isbel L, Roy M, Ng AP, Shang X, Li F.   +8 more
europepmc   +1 more source

4-2 VHL-Recruiting PROTAC Inhibits the Growth and Migration of Triple Negative Breast Cancer Cells by Triggering Pyroptosis Through Fas-Mediated IL-17 Signaling. [PDF]

Drug Dev Res
Wang Q, Huang Q, Ou H, Huang T, He Y, Li P.   +5 more
europepmc   +1 more source

Targeted degradation of Influenza a virus nucleoprotein via aptamer-based PROTACs for antiviral therapy. [PDF]

Virulence
Li W, Ju Y, Gao Y, Peng J, Qi N.
europepmc   +1 more source

Structure-guided engineering of an aptamer-PROTAC for targeted degradation of vaccinia-related kinase 1. [PDF]

Chem Sci
Yun Y, Gao Y, Shi Y, Zhang J.
europepmc   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation. [PDF]

Adv Sci (Weinh)
Liu K, Yuan X, Zhou Y, Yuan R, Xie S, Chen Y, Wang P, Gao J, Gong Q.   +8 more
europepmc   +1 more source

Generalizable Strategies for the Synthesis of Cereblon-Recruiting PROTAC Prodrugs. [PDF]

Angew Chem Int Ed Engl
Wang AX, Liu B, Ackerman EM, Xiang Y, Nguyen HV, Jiang Y, Koehler AN, Johnson JA.   +7 more
europepmc   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi-scenario applications, and translational prospects. [PDF]

Smart Mol
Qin S, Peng R, Zhang G, Yan S, Xiao J, Liu Z, Tan Z, Xie Q, Li S, Luo W, Xiao X.   +10 more
europepmc   +1 more source

From Ternary Modeling to Predictive PROTAC Design: A Computational Perspective. [PDF]

J Chem Inf Model
Schulz JM, Reynolds RC, Schürer SC.
europepmc   +1 more source

Pocket-PROTACs: an interpretable pocket-aware deep learning framework for predicting PROTAC-induced protein degradation. [PDF]

Bioinformatics
Chen K, Huang Z, Wang Y, Shen S, Song J, Deng L.   +5 more
europepmc   +1 more source

AI-assisted design and virtual profiling of targeted degraders for pancreatic cancer therapy via PROTAC technology. [PDF]

Am J Cancer Res
Du B, Wang K, Wu Z, Qiu S, Konstantinos FD, Yu S.   +5 more
europepmc   +1 more source