Results 1 to 10 of about 8,212 (230)

Targeted degradation of Influenza a virus nucleoprotein via aptamer-based PROTACs for antiviral therapy. [PDF]

Virulence
Influenza A virus (IAV) poses a serious threat to public health due to its high mutability and rapid transmissibility. The viral nucleoprotein (NP), a highly conserved and essential component, has emerged as an ideal target for antiviral therapies ...
Li W, Ju Y, Gao Y, Peng J, Qi N.
europepmc   +2 more sources

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation. [PDF]

Adv Sci (Weinh)
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Liu K, Yuan X, Zhou Y, Yuan R, Xie S, Chen Y, Wang P, Gao J, Gong Q.   +8 more
europepmc   +2 more sources

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi-scenario applications, and translational prospects. [PDF]

Smart Mol
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Qin S, Peng R, Zhang G, Yan S, Xiao J, Liu Z, Tan Z, Xie Q, Li S, Luo W, Xiao X.   +10 more
europepmc   +2 more sources

Generalizable Strategies for the Synthesis of Cereblon-Recruiting PROTAC Prodrugs. [PDF]

Angew Chem Int Ed Engl
Cereblon‐recruiting PROTACs remain challenging to derivatize for prodrug‐based delivery. In this study, three complementary conjugation strategies enabled the efficient synthesis of cleavable PROTAC prodrugs with tunable release kinetics that can be incorporated into a library of PEGylated constructs and bottlebrush prodrugs.
Wang AX, Liu B, Ackerman EM, Xiang Y, Nguyen HV, Jiang Y, Koehler AN, Johnson JA.   +7 more
europepmc   +3 more sources

DesignMaster: A Multi-Conditional Diffusion Framework for Rational PROTAC Design. [PDF]

Bioinformatics
Shi B, Hao Y, Liu J, Pan T, Isbel L, Roy M, Ng AP, Shang X, Li F.   +8 more
europepmc   +1 more source

4-2 VHL-Recruiting PROTAC Inhibits the Growth and Migration of Triple Negative Breast Cancer Cells by Triggering Pyroptosis Through Fas-Mediated IL-17 Signaling. [PDF]

Drug Dev Res
Wang Q, Huang Q, Ou H, Huang T, He Y, Li P.   +5 more
europepmc   +1 more source

Structure-guided engineering of an aptamer-PROTAC for targeted degradation of vaccinia-related kinase 1. [PDF]

Chem Sci
Yun Y, Gao Y, Shi Y, Zhang J.
europepmc   +1 more source

From Ternary Modeling to Predictive PROTAC Design: A Computational Perspective. [PDF]

J Chem Inf Model
Schulz JM, Reynolds RC, Schürer SC.
europepmc   +1 more source

Pocket-PROTACs: an interpretable pocket-aware deep learning framework for predicting PROTAC-induced protein degradation. [PDF]

Bioinformatics
Chen K, Huang Z, Wang Y, Shen S, Song J, Deng L.   +5 more
europepmc   +1 more source

AI-assisted design and virtual profiling of targeted degraders for pancreatic cancer therapy via PROTAC technology. [PDF]

Am J Cancer Res
Du B, Wang K, Wu Z, Qiu S, Konstantinos FD, Yu S.   +5 more
europepmc   +1 more source