The Proteasome Immunosubunit Multicatalytic Endopeptidase Complex-Like 1 Is a T-Cell-Intrinsic Factor Influencing Homeostatic Expansion [PDF]
Infection and Immunity, 2008 ABSTRACT Homeostatic regulatory mechanisms maintain the constant ratios between different lymphocyte subsets in the secondary lymphoid organs. How this dynamic equilibrium is achieved, in particular following the clonal expansion and subsequent contraction of different cells after infection, remains poorly understood.
Zaiss, Dietmar M W +2 more
openaire +4 more sources
Antimicrobial Peptides and Systemic Inflammation: A Network Analysis. [PDF]
Immun Inflamm DisABSTRACT Introduction Antimicrobial peptides (AMPs) are essential components of the innate immune system, exhibiting diverse mechanisms of action. Objective This study investigates the roles of cathelicidin (LL‐37), alpha‐defensins, and the S100 proteins S100A8 and S100A9 in systemic inflammation associated with sepsis, severe COVID‐19, and acute ...
Pinheiro da Silva F +2 more
europepmc +2 more sources
Akt1 Decreases Gcn5 Protein Stability through Regulating The Ubiquitin-Proteasome Pathway in Mouse Embryonic Fibroblasts [PDF]
Cell Journal, 2022 General control non-derepressible 5 (Gcn5) is a member of histone acetyltransferase (HAT) that plays key roles during embryogenesis as well as in the development of various human cancers.
Da Som Jeong +3 more
doaj +1 more source
Breast, 2021 Purpose: To assess whether contralateral parenchymal enhancement (CPE) on MRI is associated with gene expression pathways in ER+/HER2-breast cancer, and if so, whether such pathways are related to survival. Methods: Preoperative breast MRIs were analyzed
Max A.A. Ragusi +8 more
doaj +1 more source
Open Medicine, 2023 The aim of this study is to investigate the prognostic immune-related factors in breast cancer (BC) metastasis. The gene expression chip GSE159956 was downloaded from the gene expression omnibus database.
Chen Gang +6 more
doaj +1 more source
Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2020 Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a recently described chronic autoinflammatory disease, pathophysiologically related to intracellular proteasome/immunoproteasome dysfunction.
Katarina Kieselová +2 more
doaj +1 more source
Ricin trafficking in plant and mammalian cells [PDF]
, 2011 Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans).
Lord, Mike, Spooner, Robert A.
core +2 more sources
Idiosyncratic evolution of conserved eukaryote proteins that are similar in sequence to archaeal or bacterial proteins [PDF]
, 2008 Sequence comparisons have been made between the proteins of 571 prokaryote species including 46 archaea and 525 bacteria and the set of human proteins.
Roy J. Britten
core +2 more sources
The shift from low to high non-structural protein 1 expression in rotavirus-infected MA-104 cells
Memorias do Instituto Oswaldo Cruz, 2013 A hallmark of group/species A rotavirus (RVA) replication in MA-104 cells is the logarithmic increase in viral mRNAs that occurs four-12 h post-infection.
Laura Martinez-Alvarez +3 more
doaj +1 more source
Transcription, signaling receptor activity, oxidative phosphorylation, and fatty acid metabolism mediate the presence of closely related species in distinct intertidal and cold-seep habitats [PDF]
, 2015 Bathyal cold seeps are isolated extreme deep-sea environments characterized by low species diversity while biomass can be high. The Hakon Mosby mud volcano (Barents Sea, 1,280 m) is a rather stable chemosynthetic driven habitat characterized by prominent
Derycke, Sofie +3 more
core +2 more sources