An update on the landscape of collagen bioactive fragments
The FEBS Journal, Volume 293, Issue 13, Page 4064-4084, July 2026.The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
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Difference between PA700-like proteasome activator complex and the regulatory complex dissociated from the 26S proteasome implies the involvement of modulating factors in the 26S proteasome assembly [PDF]
, 1997 The PA700-like proteasome activator complex was highly purified from porcine erythrocytes, and its properties were compared with those of the regulatory complex disassembled from the purified 26S proteasome.
Sawada, Hitoshi +7 more
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The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. [PDF]
, 2014 p53 and its major E3 ligase Mdm2 are both ubiquitinated and targeted to the proteasome for degradation. Despite the importance of this in regulating the p53 pathway, little is known about the mechanisms of proteasomal recognition of ubiquitinated p53 and
J Das +11 more
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Structural investigation of two supramolecular complexes of the eukaryotic cell [PDF]
, 2008 Preface This study is focussed on the structural investigation of large molecular assemblies such as the 26S proteasome and the translocation machinery of the outer mitochondrial membrane.
Schreiner, Patrick
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Chronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 126-138, June 2026.High‐resolution single‐cell atlas of normal gastric tissue, primary gastric cancer, and metastatic lesions. (A) Schematic diagram of experimental design. (B) Bar plot for qualified cell numbers in each lesion. (C) Cells annotation by canon markers for all cells. (D) Bubble chart for canon marker genes for each cell subtype.
Min Sun +3 more
wiley +1 more source
The effects of Parkinson's disease mimetics on the proteasomal and neurofilament systems in SH-SY5Y cells [PDF]
, 2006 Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson's disease, linked recently to proteasomal dysfunction.
Caneda-Ferrón, B +1 more
core
Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner [PDF]
, 2014 The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis.
Anja Bremm +9 more
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The Plant Genome, Volume 19, Issue 2, June 2026.Abstract Polyploidization has played a key role in plant genome evolution. Eragrostis curvula (Schrad.) Ness, a perennial forage grass species of the Poaceae family, is an excellent model for investigating genome duplication due to its natural variation in ploidy levels.
D. F. Santoro +5 more
wiley +1 more source
The molecular basis of CRL4 ubiquitin ligase architecture, targeting and regulation [PDF]
, 2013 Members of the CUL4-RBX1-DDB1 (CRL4) E3 ubiquitin ligase family regulate multiple cellular processes including development, transcription, and DNA repair.
Fischer, Eric Sebastian
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, 2011 A 3D animation showing how proteins in the cell are tagged for disposal and degraded by the proteasome.
Howard Hughes Medical Institute (HHMI)
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