Results 51 to 60 of about 116,242 (180)

Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model - role of tumor stroma cells [PDF]

, 2014
Background: Hypoxia-induced genes are potential targets in cancer therapy. Responses to hypoxia have been extensively studied in vitro, however, they may differ in vivo due to the specific tumor microenvironment.
Gallé, B. (Birgit), Guelly, C. (Christian), Hofmann, N.A. (Nicole), Hrzenjak, A. (Andelko), Leithner, K. (Katharina), Lindenmann, J. (Jörg), Olschewski, A. (Andrea), Olschewski, H. (Horst), Philipsen, J.N.J. (Sjaak), Popper, H.H. (Helmut), Quehenberger, F. (Franz), Smolle-Jüttner, F.-M. (Freyja-Maria), Stacher, E. (Elvira), Stiegler, P. (Philipp), Wohlkoenig, C. (Christoph)   +14 more
core   +1 more source

Proteomics reveals three molecular subtypes of Alzheimer's disease with distinct progression patterns

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) shows marked molecular heterogeneity. Defining biological subtypes may refine diagnosis and treatment. METHODS We analyzed cerebrospinal fluid (CSF) proteomics and longitudinal data from 550 participants in the Alzheimer's Disease Neuroimaging Initiative with up to 16.5 years of follow‐up. We profiled 6361
Xiao‐He Hou, Wei Zhang, Kairan Kang, Yifei Jin, Peng Ren, Linbo Wang, Zeyu Li, Yuzhu Li, Jia You, Bei Zhang, Qing Ma, for the Alzheimer's Disease Neuroimaging Initiative, Fang Xie, Jin‐Tai Yu, Jian‐Feng Feng, Wei Cheng   +15 more
wiley   +1 more source

CellTree: an R/bioconductor package to infer the hierarchical structure of cell populations from single-cell RNA-seq data [PDF]

, 2016
GO BP Terms for myoblast data. Full table of enriched GO BP terms for each topic in myoblast data.
David A. duVerle, Hiroyuki Aburatani, Koji Tsuda, Seitaro Nomura, Sohiya Yotsukura   +4 more
core   +10 more sources

The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa

The FEBS Journal, Volume 293, Issue 4, Page 948-958, February 2026.
Metacaspases are Ca2+‐dependent cysteine proteases whose structural characteristics, particularly calcium binding and autocatalytic processing, govern their activation and biological functions. These enzymes differ among microorganisms and regulate their cell cycles, making them excellent targets for drug development.
Ane C. M. Duarte, Mariana N. R. Trujilho, Karolaine S. S. M. Valdivia, Aline F. Araujo, Laura M. C. de Lorena, Vinicius H. de Oliveira, Beatriz V. Pereira, Emilly R. Leme, Wagner A. S. Júdice, Maurício F. M. Machado   +9 more
wiley   +1 more source

A conserved set of maternal genes? Insights from a molluscan transcriptome [PDF]

, 2014
The early animal embryo is entirely reliant on maternal gene products for a ‘jump-start’ that transforms a transcriptionally inactive embryo into a fully functioning zygote.
Blaxter, Mark L., Davey, John W., Davison, Angus, Jackson, Daniel J., Liu, M. Maureen   +4 more
core   +4 more sources

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

Advanced Science, Volume 13, Issue 4, 19 January 2026.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu, Wanyi Zhao, Xinyu Chen, Yanzhou Wang, Shuoshuo Wei, Bo Xiang, Yingzhou Shi, Zongyue Li, Yangyang Yao, Jin Xie, Renyuan Qiu, Meng Shu, Shuo Xu, Ping Chen, Zhiying Chen, Yingjie Wu, Weibo Xia, Ling Gao, Yongfeng Song, Jiajun Zhao, Chao Xu   +20 more
wiley   +1 more source

Alternative Antigen Processing for MHC Class I: Multiple Roads Lead to Rome [PDF]

, 2015
The well described conventional antigen processing pathway is accountable for most peptides that end up in MHC class I molecules at the cell surface. These peptides experienced liberation by the proteasome and transport by the peptide transporter TAP ...
Aldrich, Aldrich, Bartoszewski, Bland, Braud, Cascio, Cerundolo, Chapman, Chemali, Chen, Christianson, Cresswell, Crotzer, Dalbey, de Almeida, de la Salle, Del Val, Durgeau, El Hage, English, Fluhrer, Friedmann, Garstka, Geier, Gil-Torregrosa, Glas, Henderson, Hermann, Hu, Hughes, Jahreiss, Jensen, Jeon, Johnson, Kessler, Kim, Kisselev, Klein, Kloetzel, Koble, Lampen, Lampen, Lampen, Lautscham, Lee, Lemberg, Lemberg, Leonhardt, Levine, Levy, Li, Lilley, Lorente, Lorente, Loureiro, Lu, Lyko, Martoglio, Medina, Mijaljica, Momburg, Munz, Nagarajan, Nam, Nam, Neefjes, Oehler, Oliveira, Oliveira, Oliveira, Oliveira, Parmentier, Rapoport, Reits, Reits, Riebeling, Rock, Rodgers, Sandberg, Saric, Saric, Schrul, Sebzda, Seidah, Seidah, Seidel, Seifert, Serwold, Snyder, Snyder, Snyder, Song, Spee, Susan-Resiga, Targett-Adams, Targett-Adams, Tey, Thomas, Tiwari, Urban, van de Weijer, van der Wal, van Hall, van Hall, Van Hall, Van Kaer, Voss, Vyas, Wang, Wearsch, Wei, Weihofen, Weihofen, Weinzierl, Wiertz, Wolpert, Yamada, Yewdell, Yorimitsu, York, York, Zimmer   +121 more
core   +2 more sources

Inhibition of N‐Terminal Acetyltransferase C Mitigates Endoplasmic Reticulum Stress–Mediated Muscle Atrophy in Cancer Cachexia

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Cancer cachexia is a complex syndrome marked by weight loss and muscle wasting, significantly impacting patient quality of life and survival. Mechanistically, it is characterized by suppressed protein synthesis and enhanced muscle catabolism, with the role of endoplasmic reticulum (ER) stress and unfolded protein response (UPR ...
Yusaku Kaneko, Tomohiro Hino, Shunta Taminishi, Yayoi Matoba, Daisuke Motooka, Atsushi Hoshino, Satoaki Matoba   +6 more
wiley   +1 more source

A proteinaceous organic matrix regulates carbonate mineral production in the marine teleost intestine [PDF]

, 2016
Marine teleost fish produce CaCO(3) in their intestine as part of their osmoregulatory strategy. This precipitation is critical for rehydration and survival of the largest vertebrate group on earth, yet the molecular mechanisms that regulate this ...
Adrian Pelin, Christophe M. R. LeMoine, Kevin L. Schauer, M. Danielle McDonald, Martin Grosell, Nicolas Corradi, Wesley C. Warren   +6 more
core   +2 more sources