Results 61 to 70 of about 116,242 (180)

Integrated phenotypic and proteomic screening identifies top‐tier Alzheimer's disease therapeutic targets

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Alzheimer's disease (AD) is a complex neurodegenerative disorder. Hundreds of therapeutic targets have been nominated through genetic and multi‐omic studies, but effective prioritization remains a major bottleneck. METHODS We applied an integrative screening framework to assess 29 candidate targets from risk‐enriched biological ...
Gregory A. Cary, Qianjin Li, Jesse C. Wiley, Carolyn A. Paisie, Yuhong Du, Elizabeth L. Zoeller, Duc Duong, Haian Fu, Nicholas T. Seyfried, Allan I. Levey, Ranjita Betarbet, Gregory W. Carter, for The Emory‐Sage‐SGC‐JAX TREAT‐AD Center   +12 more
wiley   +1 more source

Iron enhances reactive oxygen species generation and initiates neutrophil extracellular traps formation on the endothelium to exacerbate stroke

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Under hypoxic conditions, iron from red blood cells and injured tissues is taken up by endothelial cells. During reoxygenation, this iron is exported via Fpn1, promoting NETs formation by enhancing ROS production through the Fenton reaction, ultimately exacerbating cerebral injury.
Weijian Fan, Zebin Fang, Yuxiang Weng, Tianxiang Zhan, Kaiyuan Huang, Jianwei Pan, Renya Zhan   +6 more
wiley   +1 more source

A mammalian nervous system-specific plasma membrane proteasome complex that modulates neuronal function

Nature Structural &Molecular Biology, 2017
In the nervous system, rapidly occurring processes such as neuronal transmission and calcium signaling are affected by short-term inhibition of proteasome function. It is unclear how proteasomes are able to acutely regulate such processes, as this action
K. Ramachandran, S. S. Margolis
semanticscholar   +1 more source

Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia [PDF]

, 2014
BACKGROUND: Evidence from cachectic cancer patients and animal models of cancer cachexia supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer-induced skeletal muscle wasting. However, the genome-wide gene networks and
Beharry, Adam W., Ferreira, Leonardo F., Judge, Andrew R., Judge, Sarah M., Kandarian, Susan C., Roberts, Brandon M., Wu, Chia-Ling   +6 more
core   +1 more source

Proteasome inhibition blocks necroptosis by attenuating death complex aggregation

Cell Death and Disease, 2018
Proteasome inhibitors have achieved clinical success because they trigger intrinsic and extrinsic cell death to eliminate susceptible human cancers. The ubiquitin-proteasome protein degradation system regulates signaling pathways by controlling levels of
Mohammad Ali, E. Mocarski
semanticscholar   +1 more source

Resistance to Soybean Cyst Nematode: Rhg1 [PDF]

, 2012
The genes underlying rhg1 lie at a sometimes dominant sometimes co-dominant locus, necessary for resistance to all Hg types of the soybean (Glycine max (L.) Merr.) cyst nematode (Heterodera glycines).
Afzali, Ahmad Walid, El Shemy, Hany A., Geisler, Matt, Iqbal, M Javed, Lightfoot, David A, Natarajan, Aparna, Saini, Navinder, Srour, Ali   +7 more
core   +2 more sources

Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes, in particular in redox and energy metabolism

Leukemia, 2016
Adaptive resistance of myeloma to proteasome inhibition represents a clinical challenge, whose biology is poorly understood. Proteasome mutations were implicated as underlying mechanism, while an alternative hypothesis based on low activation status of ...
Guillem Paniagua Soriano, L. Besse, Nan Li, M. Kraus, A. Besse, N. Meeuwenoord, J. Bader, Bart Everts, H. Dulk, H. Overkleeft, B. Florea, Christoph Driessen   +11 more
semanticscholar   +1 more source

Purification and characterisation of 20S proteasome from ostrich skeletal muscle and its role in meat tenderisation [PDF]

, 2004
The proteasome is renowned for its high molecular weight, multisubunit and mulicatalytic nature. One of its many suggested roles is the degradation of myofibrillar proteins, and therefore it has been proposed to play a role in the meat tenderisation ...
Thomas, Adele René
core   +1 more source

Proteasomal protein degradation: adaptation of cellular proteolysis with impact on virus-and cytokine-mediated damage of heart tissue during myocarditis [PDF]

, 2018
Viral myocarditis is an inflammation of the heart muscle triggered by direct virus-induced cytolysis and immune response mechanisms with most severe consequences during early childhood.
Agarwal, Ajibade, Aki, Akira, Althof, Althof, Arthur, Banks, Barber, Basler, Basler, Basler, Basler, Bitzer, Blasius, Brehm, Caforio, Cascio, Chen, Chow, Chow, Cooper, Corbin-Lickfett, Cornell, Cornell, Corsten, Dantuma, Davidson, De Bruin, De Verteuil, Delboy, Deng, Deol, Deonarain, Dikic, Dimopoulos, Ebstein, Epelman, Ersching, Esfandiarei, Fehling, Feldman, Flynn, Gaczynska, Gaczynska, Gangaplara, Gao, Gebhard, Ginhoux, Godeny, Godeny, Goldberg, Gomes, Goser, Gray, Groll, Groll, Guillaume, Hallermalm, Hallett, Hayashi, Hayashi, Heaton, Henke, Hensley, Hiraoka, Horwitz, Huber, Ichikawa, Jakel, Jakubzick, Jang, Jaquenod De Giusti, Jenne, Jurk, Kalejta, Kalim, Kaspari, Kawai, Kaya, Kemball, Kemball, Kemball, Kessler, Kincaid, Kindermann, Kirschner, Kisselev, Kitamura, Klingel, Klingel, Klingel, Kloetzel, Koerner, Kuhl, Kuhl, La Frazia, Lam, Leipner, Leuschner, Li, Luo, Luo, Macagno, Magrini, Maier, Matsuzaki, Mccarthy, Mccarthy, Mcnab, Mena, Mena, Mercer, Miller, Mishto, Moebius, Muchamuel, Mundt, Mundt, Murata, Murata, Murata, Nebuloni, Nencioni, Neumann, Neznanov, Nussbaum, Opavsky, Opitz, Paeschke, Parlati, Pickart, Pickering, Prösch, Rahnefeld, Rahnefeld, Respondek, Richardson, Richardson, Ronkina, Ros, Rose, Rovere, Runnels, Sagar, Satheshkumar, Scheffner, Schmidt, Schubert, Schwarz, Seifert, Sijts, Spur, Stetson, Stewart, Strehl, Sula Karreci, Szalay, Szalay, Takeda, Takemoto, Tewari, Tian, Triantafilou, Tu, Turnell, Vachharajani, Vankaer, Visekruna, Voigt, Weinzierl, Wessely, Widjaja, Xu, Yun, Zimmermann   +175 more
core   +1 more source

An in vitro model of murine middle ear epithelium. [PDF]

, 2016
Otitis media (OM) or middle ear inflammation is the most common pediatric disease and leads to significant morbidity. Although understanding of underlying disease mechanisms is hampered by complex pathophysiology it is clear that epithelial abnormalities
Admyre, Amesara, Atherton, Bakaletz, Barnes, Bartlett, Bernstein, Bingle, Butler, Casey, Cash, Choi, Choi, Chun, Clarke, Cody, Davidson, Davies, Gao, Gaschler, Hendrixson, Herman, Horani, Horani, Juhn, Kapsogeorgou, Keller, Kerschner, Kesimer, Kim, Kondo, Lechner, Lim, Lim, Lim, Lim, Liu, Loonen, Matsui, Mcguire, Moon, Moon, Musa, Nakamura, Pillai, Portier, Preciado, Preciado, Roy, Rye, Rye, Schachern, Schousboe, Straetemans, Takeno, Thompson, Toyama, Tsuchiya, Ueyama, Vaishnava, Val, Valadi, Van Blitterswijk, Van Niel, van Rozendaal, Vladar, Woo, Woodfield, Woodworth, Wright, Wu, Yamaya, You, You   +73 more
core   +3 more sources