Results 31 to 40 of about 116,242 (180)

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, EarlyView.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase*

Journal of Biological Chemistry, 1998
Most antigenic peptides presented on major histocompatibility complex class I molecules are generated during protein breakdown by proteasomes, whose specificity is altered by interferon-γ (IFN-γ).
J. Beninga, K. Rock, A. Goldberg
semanticscholar   +1 more source

Traversing the effects of ploidy changes in different Eragrostis curvula genotypes through high‐throughput RNA sequencing

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Polyploidization has played a key role in plant genome evolution. Eragrostis curvula (Schrad.) Ness, a perennial forage grass species of the Poaceae family, is an excellent model for investigating genome duplication due to its natural variation in ploidy levels.
D. F. Santoro, J. Carballo, M. C. Pasten, C. A. Gallo, E. Albertini, V. Echenique   +5 more
wiley   +1 more source

Identification Of Novel Biomarker For Human Uterine Leiomyosarcoma [PDF]

, 2018
Sarcomas are neoplastic malignancies that typically arise in tissues of mesenchymal origin. The identification of novel molecular mechanisms leading to sarcoma formation and the establishment of new therapies has been hampered by several critical factors.
Aburatani, Hiroyuki, Hayashi, Takuma, Horiuchi, Akiko, Ishiko, Osamu, Kanai, Yae, Konishi, Ikuo, Tonegawa, Susumu, Yaegashi, Nobuo, Zharhary, Dorit   +8 more
core   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans, Ronald G. Jones III, Ana Regina Cabrera, Francielly Morena, Nicholas P. Greene, John J. McCarthy, Ahmed Ismaeel, Yuan Wen, Kevin A. Murach   +8 more
wiley   +1 more source

Genome-Wide Identification of Molecular Pathways and Biomarkers in Response to Arsenic Exposure in Zebrafish Liver [PDF]

, 2013
10.1371/journal.pone.0068737PLoS ONE87 ...
A Barchowsky, A De Vizcaya-Ruiz, A Diaz-Villasenor, A Donovan, A Mortazavi, A Ordas, AH Smith, AP Davis, AP Davis, AS Chan, AT McCurley, AT McKie, AT Nguyen, BE Bachmeier, BK Mandal, BM Forman, C Camaschella, CF Huang, CO Abernathy, D Chang, D Lyden, DB Tully, DC Radisky, DW Crabb, EG Beale, F Muller, FB Pichler, FP Guengerich, FQ Schafer, G Papanikolaou, G Schmitz, GM Brittenham, H Liu, H Shi, H Takagi, Hongyan Xu, HV Aposhian, HV Aposhian, I De Domenico, IG Woods, IG Woods, J Hellemans, J Liu, J Vandesompele, JH Lee, JH Postlethwait, JM Catchen, JP McGrath, K Jomova, K Larade, L Guo, L Shi, LT Vassilev, M Cavigelli, M Darabi, M Merkofer, M Schuliga, M Tenopoulou, MA Deeg, MA Rea, MC Hollander, MD Jacobs, MK Parr, MR de Castro, MS Hayden, MU Muckenthaler, NC Popescu, OW Stockhammer, P Arosio, P Ghosh, PC Adams, PJ Barter, PT Doulias, RC Habbersett, RC Kaltreider, RS Esworthy, RW Mahley, S Abboud, S Cai, S Fendorf, S Hasegawa, S Levi, S Maiti, SC Andrews, SH Lam, SH Lam, Siew Hong Lam, SJ Flora, SK Baird, SL Doyle, SM Cohen, SR Grossman, TD Gilmore, TK Hei, TP Dalton, W Huang da, W Zheng, W Zheng, Xiaoping Pan, XP Jiang, Y Haupt, Y Qiu, Yuan Shen, YW Zhang, Z Hegedus, Z Kosa, Zhiyuan Gong   +106 more
core   +3 more sources

Proteomic Analysis of Cervicovaginal Fluid for Diagnostic Endometriosis Biomarker Discovery

PROTEOMICS – Clinical Applications, Volume 20, Issue 3, May 2026.
ABSTRACT Purpose Endometriosis is a prevalent inflammatory condition characterised by the presence of endometrial‐like tissue outside the uterus and is associated with significant challenges, including diagnostic delays and continued reliance on laparoscopy.
Emily S. J. Paterson, Simon Scheck, Torsten Kleffmann, Roopi Gill, Nicholas Bedford, Simon McDowell, Jane E. Girling, Claire E. Henry   +7 more
wiley   +1 more source

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency

Scientific Reports, 2018
By N-ethyl-N-nitrosourea (ENU) mutagenesis, we generated the mutant mouse line TUB6 that is characterised by severe combined immunodeficiency (SCID) and systemic sterile autoinflammation in homozygotes, and a selective T cell defect in heterozygotes. The
Irina Treise, E. Huber, Tanja Klein-Rodewald, W. Heinemeyer, S. Grassmann, Michael Basler, T. Adler, B. Rathkolb, L. Helming, C. Andres, M. Klaften, Christina Landbrecht, T. Wieland, T. Strom, K. McCoy, A. Macpherson, E. Wolf, M. Groettrup, M. Ollert, F. Neff, V. Gailus-Durner, H. Fuchs, M. Hrabě de Angelis, M. Groll, D. Busch   +24 more
semanticscholar   +1 more source