Results 31 to 40 of about 5,322,139 (136)

Apoplast multi‐omics profiling during fungal infection uncovers new players of basal and early induced immunity in Arabidopsis thaliana

New Phytologist, EarlyView.
Important processes taking place in the apoplast during plant–pathogen interaction identified by multi‐omics profiling of the apoplastic fluid. Summary The extracellular space in plant tissues, known as the apoplast, remains one of the least characterized cellular compartments.
Antoine Davière, Sylvie Jolivet, Annie Auger, Gilles Clement, Stephanie Boutet, Jean Chrisologue Totozafy, Thierry Balliau, Mélisande Blein‐Nicolas, Justine Rouffet, Marie‐Christine Soulié, Mathilde Fagard   +10 more
wiley   +1 more source

Plant NAOGAT (ArgJ) Structure Reveals Mechanism of Ornithine Biosynthesis, Preference for Acetylornithine and Susceptibility to Mangotoxin

Plant, Cell &Environment, EarlyView.
ABSTRACT Arginine metabolism in plants is targeted by phytopathogens such as Pseudomonas syringae strains, which produce toxins that affect enzymes of plant arginine metabolism, causing devastating infections in crops. In this work, the structural and functional properties of plant N‐acetylornithine glutamate acetyltransferase (NAOGAT), the key ...
Maciej Nielipinski, Agnieszka J. Pietrzyk‐Brzezinska, Aleksandra Twarda‐Clapa, Bartosz Sekula   +3 more
wiley   +1 more source

The Proteasome

, 2016
A 3D animation showing how proteins in the cell are tagged for disposal and degraded by the proteasome.
Howard Hughes Medical Institute (HHMI)
core   +2 more sources

Genome‐Wide Association Studies of Micro‐and Macro‐Mineral Concentrations in Cultivated, Wild and Native Pea

Legume Science, Volume 8, Issue 4, December 2026.
ABSTRACT Pea (Pisum sativum) is a nutrient‐rich crop that can provide essential nutrients needed for human and animal health. Improving its mineral concentration through genetic selection can enhance its nutritional value and help combat micronutrient deficiencies. This study aimed to investigate the genetic basis of the accumulation of eight minerals (
Maryam Bagheri, Carla S. Santos, Diego Rubiales, Osman Zakaria Wohor, Marta W. Vasconcelos   +4 more
wiley   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, Volume 58, Issue 6, Page 1552-1569, November 2026.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Coat Color‐Associated Transcriptomic Differences of Black and White Hortobágyi Racka Sheep Using the RNA‐Seq Technique

Ecology and Evolution, Volume 16, Issue 10, October 2026.
We compared skin transcriptomes of black‐ and white‐coated Hortobágyi Racka sheep using RNA‐seq to identify coat color‐associated molecular differences. Black‐coated sheep showed coordinated upregulation of melanogenesis and melanosome‐related genes together with pathways linked to redox balance, mitochondrial metabolism, and thermogenesis.
Putri Kusuma Astuti, Zoltán Bagi, Lilla Bodrogi, Szilvia Kusza   +3 more
wiley   +1 more source

Systematic Analysis of Plasma‐Derived Extracellular Vesicle‐Enriched Samples in Age‐Related Macular Degeneration Reveals Oxidative Stress Linked to Altered Lipid and Protein Profiles

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Vision impairment caused by age‐related macular degeneration (AMD) is a global health priority. Retinal pathology is driven by ageing and exacerbated by genetic and environmental risk factors. Peripheral blood circulation is increasingly recognised as a contributor to disease initiation and progression, and a source of biomarkers to support ...
Marzena Kurzawa‐Akanbi, Jennifer Haggarty, Carina Hansohn, Mohamed T. Patel, Angela J. Cree, Peisi Teo, Milly Armstrong, Nathan Coles, Mark Platt, Helen Griffiths, Heather J. Cordell, Ahmad Khundakar, Pola Goldberg Oppenheimer, Phillip Whitfield, Andrew Lotery, Henning Urlaub, Sina Mozaffari‐Jovin, Majlinda Lako   +17 more
wiley   +1 more source

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Black Sheep: Pseudokinases Bucking the Trend to Reveal Non‐Catalytic Kinase Functions

IUBMB Life, Volume 78, Issue 8, August 2026.
ABSTRACT Pseudokinases are the catalytically‐dead counterparts of protein kinases and, over the past 20 years, have increasingly garnered attention as crucial signaling entities—comprehensively dispelling the possibility that they are merely evolutionary remnants or cellular passengers.
James M. Murphy, Natalia Jura, Peter D. Mace   +2 more
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source