Results 11 to 20 of about 176,579 (332)
Expanding PROTACtable genome universe of E3 ligases
Nature Communications, 2023 Proteolysis-targeting chimera (PROTAC) and other targeted protein degradation (TPD) molecules that induce degradation by the ubiquitin-proteasome system (UPS) offer new opportunities to engage targets that remain challenging to be inhibited by ...
Yuan Liu +9 more
doaj +2 more sources
Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control
Molecules, 2021 Skeletal muscle loss is a detrimental side-effect of numerous chronic diseases that dramatically increases mortality and morbidity. The alteration of protein homeostasis is generally due to increased protein breakdown while, protein synthesis may also be
Dulce Peris-Moreno +4 more
doaj +2 more sources
E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration
Frontiers in Molecular Neuroscience, 2017 Cells regularly synthesize new proteins to replace old or damaged proteins. Deposition of various aberrant proteins in specific brain regions leads to neurodegeneration and aging.
Arun Upadhyay +6 more
doaj +2 more sources
Antibody targeting of E3 ubiquitin ligases for receptor degradation
Nature, 2022 Most current therapies that target plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. However, typical mammalian proteins comprise multiple domains that execute discrete but coordinated activities. Thus, inhibition
Hadir Marei +37 more
semanticscholar +1 more source
Plant E3 Ligases and Their Role in Abiotic Stress Response
Cells, 2022 Plants, as sessile organisms, have limited means to cope with environmental changes. Consequently, they have developed complex regulatory systems to ameliorate abiotic stresses im-posed by environmental changes.
Raed Al-Saharin +2 more
semanticscholar +1 more source
Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation.
Cell Chemical Biology, 2021 Efficacy and selectivity of molecules inducing protein degradation depend on their affinity to the target protein but also on the type of E3 ubiquitin ligase that is recruited to trigger proteasomal degradation. While tremendous progress has been made on
A. Kannt, Ivan Đikić
semanticscholar +1 more source
Ligandability of E3 Ligases for Targeted Protein Degradation Applications.
Biochemistry, 2021 Targeted protein degradation (TPD) using proteolysis targeting chimeras (PROTACs) and molecular glue degraders has arisen as a powerful therapeutic modality for eliminating disease-causing proteins from cells.
Bridget P. Belcher +2 more
semanticscholar +1 more source
Thermostable DNA ligases from hyperthermophiles in biotechnology
Frontiers in Microbiology, 2023 DNA ligase is an important enzyme ubiquitous in all three kingdoms of life that can ligate DNA strands, thus playing essential roles in DNA replication, repair and recombination in vivo.
Jingru Shi +3 more
doaj +1 more source
Challenges in the use of sortase and other peptide ligases for site-specific protein modification
Chemical Society Reviews, 2022 Site-specific protein modification is a widely-used biochemical tool. However, there are many challenges associated with the development of protein modification techniques, in particular, achieving site-specificity, reaction efficiency and versatility ...
H. Morgan, W. Turnbull, M. Webb
semanticscholar +1 more source
Ubiquitin-protein ligases [PDF]
Journal of Cell Science, 2004 Post-translational covalent tagging of proteins with the 76-residue protein ubiquitin (Ub) serves many functions. Polyubiquitylated proteins are directed to the large multi-component, multi-catalytic protease the 26S proteasome.
P A, Robinson, H C, Ardley
openaire +2 more sources