Results 31 to 40 of about 49,846 (154)

Obesity and lipid stress inhibit carnitine acetyltransferase activity[S]

Journal of Lipid Research, 2014
Carnitine acetyltransferase (CrAT) is a mitochondrial matrix enzyme that catalyzes the interconversion of acetyl-CoA and acetylcarnitine. Emerging evidence suggests that this enzyme functions as a positive regulator of total body glucose tolerance and ...
Sarah E. Seiler, Ola J. Martin, Robert C. Noland, Dorothy H. Slentz, Karen L. DeBalsi, Olga R. Ilkayeva, Jie An, Christopher B. Newgard, Timothy R. Koves, Deborah M. Muoio   +9 more
doaj   +1 more source

Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells

Journal of Lipid Research, 2006
The purpose of this study was to investigate the effects of long-chain fatty acids (LCFAs) on AMP-activated protein kinase (AMPK) and acetyl-coenzyme A carboxylase (ACC) phosphorylation and β-oxidation in skeletal muscle.
S. Fediuc, M.P. Gaidhu, R.B. Ceddia
doaj   +1 more source

Immunostimulatory effects of vitamin B5 improve anticancer immunotherapy

OncoImmunology, 2022
Vitamin B5 (panthotenic acid), the precursor of coenzyme A (CoA), is contained in most food items and is produced by the intestinal microbiota. A recent study published in Cell Metabolism reports that vitamin B5 and CoA favor the differentiation of CD8 ...
Melanie Bourgin, Oliver Kepp, Guido Kroemer   +2 more
doaj   +1 more source

Regulation of Acetyl-Coenzyme A Carboxylase and Acetyl-Coenzyme A Synthetase in Spinach Chloroplasts

Zeitschrift für Naturforschung C, 1984
In analogy to chloroplast fatty acid synthesis from acetate the key enzymes of acetate fixation, acetyl-CoA synthetase and acetyl-CoA carboxylase, in rapidly Triton X-100 lysed spinach chloroplasts show an activation by light and deactivation in the dark. The stim ulation of acetyl-CoA carboxylase by dithiothreitol in darkened chloroplasts points to an
Andreas Sauer, Klaus-Peter Heise
openaire   +1 more source

Characterization of Maize Acetyl-Coenzyme A Carboxylase [PDF]

Plant Physiology, 1993
Maize (Zea mays L.) leaf acetyl-CoA carboxylase (ACCase) was purified about 500-fold by ammonium sulfate fractionation and gel filtration and blue Sepharose affinity and anion-exchange chromatography. Most ACCase activity (85%) recovered from the anion-exchange column was found in a highly purified fraction (specific activity 5.5 [mu]mol acid-stable ...
M. A., Egli, B. G., Gengenbach, J. W., Gronwald, D. A., Somers, D. L., Wyse   +4 more
openaire   +2 more sources

Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells

Journal of Lipid Research, 2007
Glial cells play a pivotal role in brain fatty acid metabolism and membrane biogenesis. However, the potential regulation of lipogenesis and cholesterologenesis by fatty acids in glial cells has been barely investigated.
Francesco Natali, Luisa Siculella, Serafina Salvati, Gabriele V. Gnoni   +3 more
doaj   +1 more source

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses.

PLoS Biology, 2020
The metabolite acetyl-coenzyme A (acetyl-CoA) serves as an essential element for a wide range of cellular functions including adenosine triphosphate (ATP) production, lipid synthesis, and protein acetylation.
Ryan Houston, Shiori Sekine, Michael J Calderon, Fayaz Seifuddin, Guanghui Wang, Hiroyuki Kawagishi, Daniela A Malide, Yuesheng Li, Marjan Gucek, Mehdi Pirooznia, Alissa J Nelson, Matthew P Stokes, Jacob Stewart-Ornstein, Steven J Mullett, Stacy G Wendell, Simon C Watkins, Toren Finkel, Yusuke Sekine   +17 more
doaj   +1 more source

Acetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule

Nature Communications
The AMP-forming acetyl-CoA synthetase is regulated by lysine acetylation both in bacteria and eukaryotes. However, the underlying mechanism is poorly understood.
Chuan Qin, Leonie G. Graf, Kilian Striska, Markus Janetzky, Norman Geist, Robin Specht, Sabrina Schulze, Gottfried J. Palm, Britta Girbardt, Babett Dörre, Leona Berndt, Stefan Kemnitz, Mark Doerr, Uwe T. Bornscheuer, Mihaela Delcea, Michael Lammers   +15 more
doaj   +1 more source

Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development

Discover Oncology, 2022
Acetyl-CoA synthetase 2 (ACSS2), an important member of the acetyl-CoA synthetase (ACSS) family, can catalyze the conversion of acetate to acetyl coenzyme A (acetyl-CoA).
Rui Ling, Gong Chen, Xiang Tang, Na Liu, Yuepeng Zhou, Deyu Chen   +5 more
doaj   +1 more source

Exploring the Role of ATP-Citrate Lyase in the Immune System

Frontiers in Immunology, 2021
Studies over the past decade have revealed that metabolism profoundly influences immune responses. In particular, metabolism causes epigenetic regulation of gene expression, as a growing number of metabolic intermediates are substrates for histone post ...
Monica Dominguez, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Dmitry Namgaladze   +5 more
doaj   +1 more source