Results 51 to 60 of about 89,501 (268)
Diacetyl as Acetyl Donor [PDF]
, 1956 Diacetyl can serve as an acetyl donor for the forlnation of citrate and the acetylation of sulfanilamide in the dog heart homogenate. Diphosphothiamine and coenzyme A are essential for these reactions.
Fujii, Takao +2 more
core +1 more source
CoA protects against the deleterious effects of caloric overload in Drosophila [PDF]
, 2016 We developed a Drosophila model of T2D in which high sugar (HS) feeding leads to insulin resistance. In this model, adipose TG storage is protective against fatty acid toxicity and diabetes.
Baranski, Thomas J +2 more
core +2 more sources
Carbon assimilation strategies in ultrabasic groundwater: clues from the integrated study of a serpentinization-influenced aquifer [PDF]
, 2020 © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Seyler, L. M., Brazelton, W. J., McLean, C., Putman, L. I., Hyer, A., Kubo, M. D.
Brazelton, William J. +8 more
core +2 more sources
Obesity and lipid stress inhibit carnitine acetyltransferase activity[S]
Journal of Lipid Research, 2014 Carnitine acetyltransferase (CrAT) is a mitochondrial matrix enzyme that catalyzes the interconversion of acetyl-CoA and acetylcarnitine. Emerging evidence suggests that this enzyme functions as a positive regulator of total body glucose tolerance and ...
Sarah E. Seiler +9 more
doaj +1 more source
Immunostimulatory effects of vitamin B5 improve anticancer immunotherapy
OncoImmunology, 2022 Vitamin B5 (panthotenic acid), the precursor of coenzyme A (CoA), is contained in most food items and is produced by the intestinal microbiota. A recent study published in Cell Metabolism reports that vitamin B5 and CoA favor the differentiation of CD8 ...
Melanie Bourgin +2 more
doaj +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Autophagy, 2014 As the major lysosomal degradation pathway, autophagy represents the guardian of cellular homeostasis, removing damaged and potentially harmful material and replenishing energy reserves in conditions of starvation. Given its vast physiological importance, autophagy is crucially involved in the process of aging and associated pathologies.
Schroeder, S. +15 more
openaire +3 more sources
Draft Genome Sequence for Desulfovibrio africanus Strain PCS. [PDF]
, 2013 Desulfovibrio africanus strain PCS is an anaerobic sulfate-reducing bacterium (SRB) isolated from sediment from Paleta Creek, San Diego, CA. Strain PCS is capable of reducing metals such as Fe(III) and Cr(VI), has a cell cycle, and is predicted to ...
Arkin, Adam P +6 more
core +2 more sources
Advanced Science, EarlyView.We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun +5 more
wiley +1 more source
Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses.
PLoS Biology, 2020 The metabolite acetyl-coenzyme A (acetyl-CoA) serves as an essential element for a wide range of cellular functions including adenosine triphosphate (ATP) production, lipid synthesis, and protein acetylation.
Ryan Houston +17 more
doaj +1 more source