Results 51 to 60 of about 50,102 (223)

Immunostimulatory effects of vitamin B5 improve anticancer immunotherapy

OncoImmunology, 2022
Vitamin B5 (panthotenic acid), the precursor of coenzyme A (CoA), is contained in most food items and is produced by the intestinal microbiota. A recent study published in Cell Metabolism reports that vitamin B5 and CoA favor the differentiation of CD8 ...
Melanie Bourgin, Oliver Kepp, Guido Kroemer   +2 more
doaj   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Acetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule

Nature Communications
The AMP-forming acetyl-CoA synthetase is regulated by lysine acetylation both in bacteria and eukaryotes. However, the underlying mechanism is poorly understood.
Chuan Qin, Leonie G. Graf, Kilian Striska, Markus Janetzky, Norman Geist, Robin Specht, Sabrina Schulze, Gottfried J. Palm, Britta Girbardt, Babett Dörre, Leona Berndt, Stefan Kemnitz, Mark Doerr, Uwe T. Bornscheuer, Mihaela Delcea, Michael Lammers   +15 more
doaj   +1 more source

Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells

Journal of Lipid Research, 2007
Glial cells play a pivotal role in brain fatty acid metabolism and membrane biogenesis. However, the potential regulation of lipogenesis and cholesterologenesis by fatty acids in glial cells has been barely investigated.
Francesco Natali, Luisa Siculella, Serafina Salvati, Gabriele V. Gnoni   +3 more
doaj   +1 more source

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses.

PLoS Biology, 2020
The metabolite acetyl-coenzyme A (acetyl-CoA) serves as an essential element for a wide range of cellular functions including adenosine triphosphate (ATP) production, lipid synthesis, and protein acetylation.
Ryan Houston, Shiori Sekine, Michael J Calderon, Fayaz Seifuddin, Guanghui Wang, Hiroyuki Kawagishi, Daniela A Malide, Yuesheng Li, Marjan Gucek, Mehdi Pirooznia, Alissa J Nelson, Matthew P Stokes, Jacob Stewart-Ornstein, Steven J Mullett, Stacy G Wendell, Simon C Watkins, Toren Finkel, Yusuke Sekine   +17 more
doaj   +1 more source

The Compartmentation of Acetyl-Coenzyme A Carboxylase in Plants [PDF]

Plant Physiology, 1995
Although the biochemical pathways for fatty acid synthesis are more or less similar in plants and animals (Harwood, 1988), there is a major cell biological difference between these two groups of eukaryotes. In plants, the major site of fatty acid synthesis is the plastid, an organelle absent from the animal cell.
Y., Sasaki, T., Konishi, Y., Nagano
openaire   +2 more sources

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

Advanced Science
Besides the traditional carbon sources, Acetyl coenzyme A has recently been shown to be generated from acetate in various cancers, which subsequently promotes tumor growth and immune escape.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
doaj   +1 more source

Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development

Discover Oncology, 2022
Acetyl-CoA synthetase 2 (ACSS2), an important member of the acetyl-CoA synthetase (ACSS) family, can catalyze the conversion of acetate to acetyl coenzyme A (acetyl-CoA).
Rui Ling, Gong Chen, Xiang Tang, Na Liu, Yuepeng Zhou, Deyu Chen   +5 more
doaj   +1 more source

Exploring the Role of ATP-Citrate Lyase in the Immune System

Frontiers in Immunology, 2021
Studies over the past decade have revealed that metabolism profoundly influences immune responses. In particular, metabolism causes epigenetic regulation of gene expression, as a growing number of metabolic intermediates are substrates for histone post ...
Monica Dominguez, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Dmitry Namgaladze   +5 more
doaj   +1 more source