Results 51 to 60 of about 49,846 (154)

Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression

Journal of Experimental & Clinical Cancer Research
Background Aberrant glycogen metabolism drives lipid accumulation and adaptive lipid homeostasis reprogramming, a metabolic adaptation critical for sustaining malignant progression and chemoresistance in cholangiocarcinoma (CCA).
Yani Pan, Nannan Zhang, Xueni Fu, Xinyu Wang, Yichun Ma, Qi Chen, Yue Zhou, Hongwen Liu, Yun Zhu, Lei Xu, Qiang Wang, Dongyin Chen, Zhangding Wang, Lei Wang   +13 more
doaj   +1 more source

Acetyl-CoA synthase 1 mediates metabolic reprogramming to promote proliferation and metastasis of osteosarcoma

Journal of Orthopaedic Translation
Background: Although the combination of surgery and chemotherapy has dramatically improved the prognosis of patients with osteosarcoma (OS), the prognosis of OS patients with metastatic or recurrent tumors remains poor.
Xiuming He, Mengliang Luo, Chenyang Wang, Lingkai Kong, Jianglong Li, Jianye Tan, Junhao Chen, Yi Nie, Hantao Chen, Zhipeng Zou, Zexin Su, Lijun Lin   +11 more
doaj   +1 more source

PanM, an Acetyl-Coenzyme A Sensor Required for Maturation of l-Aspartate Decarboxylase (PanD)

mBio, 2012
Coenzyme A (CoA) is essential for cellular chemistry in all forms of life. The pantothenate moiety of CoA is generated from the condensation of pantoate and β-alanine.
Tara N. Stuecker, Alex C. Tucker, Jorge C. Escalante-Semerena   +2 more
doaj   +1 more source

Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis

Journal of Lipid Research, 2019
Deuterated water (2H2O) is widely used for measuring de novo lipogenesis (DNL). 2H is incorporated into fatty acids via exchange between body water and the hydrogens of acetyl-CoA, malonyl-CoA, and NADPH.
Getachew Debas Belew, Joao Silva, Joao Rito, Ludgero Tavares, Ivan Viegas, Jose Teixeira, Paulo J. Oliveira, Maria Paula Macedo, John G. Jones   +8 more
doaj   +1 more source

Diabetes Primes Neutrophils for Neutrophil Extracellular Trap Formation through Trained Immunity

Research
Neutrophils are primed for neutrophil extracellular trap (NET) formation during diabetes, and excessive NET formation from primed neutrophils compromises wound healing in patients with diabetes.
Sanjeeb Shrestha, Yu-Bin Lee, Hoyul Lee, Yeon-Kyung Choi, Bo-Yoon Park, Mi-Jin Kim, Young-Jin Youn, Sun-Hwa Kim, Soo-Jung Jung, Dong-Keun Song, Hee Kyung Jin, Jae-Sung Bae, In-Kyu Lee, Jae-Han Jeon, Chang-Won Hong   +14 more
doaj   +1 more source

Analysis of the drug target of the anti-tuberculosis compound OCT313: phosphotransacetylase is a potential drug target for anti-mycobacterial agents

mSphere
Tuberculosis (TB) is one of the most common infectious diseases caused by bacteria worldwide. The increasing prevalence of multidrug-resistant TB (MDR-TB) and latent TB infection (LTBI) has intensified the global TB burden.
Takemasa Takii, Tomohiro Hasegawa, Saotomo Itoh, Shinji Maeda, Takayuki Wada, Yasuhiro Horita, Akihito Nishiyama, Sohkichi Matsumoto, Naoya Ohara, Aoi Kimishima, Yukihiro Asami, Shigeaki Hida, Kikuo Onozaki   +12 more
doaj   +1 more source

ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch

Cell Reports, 2016
Mechanisms of metabolic flexibility enable cells to survive under stressful conditions and can thwart therapeutic responses. Acetyl-coenzyme A (CoA) plays central roles in energy production, lipid metabolism, and epigenomic modifications.
Steven Zhao, AnnMarie Torres, Ryan A. Henry, Sophie Trefely, Martina Wallace, Joyce V. Lee, Alessandro Carrer, Arjun Sengupta, Sydney L. Campbell, Yin-Ming Kuo, Alexander J. Frey, Noah Meurs, John M. Viola, Ian A. Blair, Aalim M. Weljie, Christian M. Metallo, Nathaniel W. Snyder, Andrew J. Andrews, Kathryn E. Wellen   +18 more
doaj   +1 more source

Multi-Method Quantification of Acetyl-Coenzyme A and Further Acyl-Coenzyme A Species in Normal and Ischemic Rat Liver. [PDF]

Int J Mol Sci, 2023
Tokarska-Schlattner M, Zeaiter N, Cunin V, Attia S, Meunier C, Kay L, Achouri A, Hiriart-Bryant E, Couturier K, Tellier C, El Harras A, Elena-Herrmann B, Khochbin S, Le Gouellec A, Schlattner U.   +14 more
europepmc   +1 more source

Carboxylation of acetonyldethio‐coenzyme a by acetyl coenzyme a carboxylase

FEBS Letters, 1978
Nikawa, Jun-ichi, Numa, Shosaku, Shiba, Tetsuo, Stewart, Charles J., Wieland, Theodor   +4 more
openaire   +4 more sources

Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cellss⃞

Journal of Lipid Research, 2007
Black tea is one of the world's most popular beverages, and its health-promoting effects have been intensively investigated. The antiobesity and hypolipidemic effects of black tea have attracted increasing interest, but the mechanisms underlying these ...
Chih-Li Lin, Hsiu-Chen Huang, Jen-Kun Lin   +2 more
doaj   +1 more source