SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress
eLifeDe novo lipogenesis is associated with the development of human diseases such as cancer, diabetes, and obesity. At the core of lipogenesis lies acetyl coenzyme A (CoA), a metabolite that plays a crucial role in fatty acid synthesis.
Rezwana Karim +3 more
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Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis
Cell ReportsSummary: ATP-citrate lyase (ACLY) generates cytosolic acetyl-coenzyme A (acetyl-CoA) for lipid synthesis and is a promising therapeutic target in diseases with altered lipid metabolism.
Phuong T.T. Nguyen +17 more
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Acetyl Coenzyme A Synthase 2 Acts as a Prognostic Biomarker Associated with Immune Infiltration in Cervical Squamous Cell Carcinoma. [PDF]
Cancers (Basel), 2021 Li CJ +5 more
europepmc +1 more source
Evolution and Characterization of Acetyl Coenzyme A: Diacylglycerol Acyltransferase Genes in Cotton Identify the Roles of GhDGAT3D in Oil Biosynthesis and Fatty Acid Composition. [PDF]
Genes (Basel), 2021 Zhao YP +6 more
europepmc +1 more source
A subset of synaptic transmission events is coupled to acetyl coenzyme A production.
J Neurophysiol, 2022 Jakkamsetti V, Ma Q, Pascual JM.
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THE OXIDATION OF ACETALDEHYDE TO ACETYL COENZYME A
Journal of Biological Chemistry, 1953 R M, BURTON, E R, STADTMAN
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Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer. [PDF]
Gastroenterology, 2022 Zhou Z +11 more
europepmc +1 more source
SUCCINYL AND ACETYL COENZYME A DEACYLASES
Journal of Biological Chemistry, 1952 J, GERGELY, P, HELE, C V, RAMAKRISHNAN
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