Results 41 to 50 of about 49,846 (154)

The Compartmentation of Acetyl-Coenzyme A Carboxylase in Plants [PDF]

Plant Physiology, 1995
Although the biochemical pathways for fatty acid synthesis are more or less similar in plants and animals (Harwood, 1988), there is a major cell biological difference between these two groups of eukaryotes. In plants, the major site of fatty acid synthesis is the plastid, an organelle absent from the animal cell.
Y., Sasaki, T., Konishi, Y., Nagano
openaire   +2 more sources

Unstructured regions of large enzymatic complexes control the availability of metabolites with signaling functions

Cell Communication and Signaling, 2020
Metabolites produced via traditional biochemical processes affect intracellular communication, inflammation, and malignancy. Unexpectedly, acetyl-CoA, α-ketoglutarate and palmitic acid, which are chemical species of reactions catalyzed by highly abundant,
Ioannis Skalidis, Christian Tüting, Panagiotis L. Kastritis   +2 more
doaj   +1 more source

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

Advanced Science
Besides the traditional carbon sources, Acetyl coenzyme A has recently been shown to be generated from acetate in various cancers, which subsequently promotes tumor growth and immune escape.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
doaj   +1 more source

Profiling of cytosolic and peroxisomal acetyl-CoA metabolism in Saccharomyces cerevisiae.

PLoS ONE, 2012
As a key intracellular metabolite, acetyl-coenzyme A (acetyl-CoA) plays a major role in various metabolic pathways that link anabolism and catabolism. In the yeast Saccharomyces cerevisiae, acetyl-CoA involving metabolism is compartmentalized, and may ...
Yun Chen, Verena Siewers, Jens Nielsen
doaj   +1 more source

Construction of an artificial phosphoketolase pathway that efficiently catabolizes multiple carbon sources to acetyl-CoA.

PLoS Biology, 2023
The canonical glycolysis pathway is responsible for converting glucose into 2 molecules of acetyl-coenzyme A (acetyl-CoA) through a cascade of 11 biochemical reactions.
Yiqun Yang, Yuwan Liu, Haodong Zhao, Dingyu Liu, Jie Zhang, Jian Cheng, Qiaoyu Yang, Huanyu Chu, Xiaoyun Lu, Mengting Luo, Xiang Sheng, Yi-Heng P J Zhang, Huifeng Jiang, Yanhe Ma   +13 more
doaj   +1 more source

Activation of immobilized acetyl-Coenzyme A carboxylase [PDF]

Biochemical Journal, 1978
Partially purified acetyl-CoA carboxylase was covalently bound to a Sepharose 4B matrix. Although aggregation was thus prevented, the enzymic activity was stimulated by citrate and isocitrate.
A D, Landman, J, Lampert
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The Role of Acetyl-Coenzyme A Synthetase in Arabidopsis [PDF]

Plant Physiology, 2008
The acs1 knockout mutant that has a disruption in the plastidic acetyl-coenzyme A (CoA) synthetase (ACS; At5g36880) gene was used to explore the role of this protein and plastidic acetate metabolism in Arabidopsis (Arabidopsis thaliana). Disruption of the ACS gene decreased ACS activity by 90% and largely blocked the incorporation of exogenous (14)C ...
Lin, Ming, Oliver, David
openaire   +3 more sources

Mitochondrial fatty acid beta-oxidation

EXCLI Journal : Experimental and Clinical Sciences
Peripheral artery disease (PAD) is an atherosclerotic disease impacting over 200 million individuals and the prevalence increases with age. PAD occurs when plaque builds up within the peripheral arteries, leading to reduced blood flow and oxygen supply ...
Cassandra E. Bradley, Emma Fletcher, Trevor Wilkinson, Andrew Ring, Lucas Cardona Ferrer, Dimitrios Miserlis, Pal Pacher, Panagiotis Koutakis   +7 more
doaj   +1 more source

Glut1 deficiency (G1D): Epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype

Neurobiology of Disease, 2012
Brain glucose supplies most of the carbon required for acetyl-coenzyme A (acetyl-CoA) generation (an important step for myelin synthesis) and for neurotransmitter production via further metabolism of acetyl-CoA in the tricarboxylic acid (TCA) cycle ...
Isaac Marin-Valencia, Levi B. Good, Qian Ma, Joao Duarte, Teodoro Bottiglieri, Christopher M. Sinton, Charles W. Heilig, Juan M. Pascual   +7 more
doaj   +1 more source

Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics, and Oncogenesis – Part 2: Acetate and ACSS2 in Health and Disease

Frontiers in Physiology, 2020
Acetate, the shortest chain fatty acid, has been implicated in providing health benefits whether it is derived from the diet or is generated from microbial fermentation of fiber in the gut.
John R. Moffett, Narayanan Puthillathu, Ranjini Vengilote, Diane M. Jaworski, Aryan M. Namboodiri   +4 more
doaj   +1 more source