Pyrophosphate-Dependent ATP Formation from Acetyl Coenzyme A in
mBio, 2016 Syntrophus aciditrophicus is a model syntrophic bacterium that degrades key intermediates in anaerobic decomposition, such as benzoate, cyclohexane-1-carboxylate, and certain fatty acids, to acetate when grown with hydrogen-/formate-consuming ...
Kimberly L. James +17 more
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Profiling of cytosolic and peroxisomal acetyl-CoA metabolism in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2012 As a key intracellular metabolite, acetyl-coenzyme A (acetyl-CoA) plays a major role in various metabolic pathways that link anabolism and catabolism. In the yeast Saccharomyces cerevisiae, acetyl-CoA involving metabolism is compartmentalized, and may ...
Yun Chen, Verena Siewers, Jens Nielsen
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Truncation of LPD1 promoter and adaptive evolution increase cytosolic acetyl-CoA supply in yeast [PDF]
Synthetic and Systems BiotechnologyAcetyl-CoA is a central metabolic intermediate that serves as a key precursor for the biosynthesis of high-value compounds such as terpenoids. However, its compartmentalization within Saccharomyces cerevisiae limits its availability in the cytosol ...
Ling Qin +5 more
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Engineering yeast peroxisome assembly enables the increased production of acetyl-CoA and its derived 5-deoxyflavonoids [PDF]
Nature CommunicationsAcetyl-CoA serves as a foundational precursor and energy source for various biosynthesis pathways. The insufficient supply of acetyl-CoA in cytosol is usually a bottleneck for exogenous chemical synthesis in engineered microbes such as yeast. Exportation
Yongxing Li +3 more
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Acetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule [PDF]
Nature CommunicationsThe AMP-forming acetyl-CoA synthetase is regulated by lysine acetylation both in bacteria and eukaryotes. However, the underlying mechanism is poorly understood.
Chuan Qin +15 more
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Targeting acetyl-CoA carboxylase 1 for cancer therapy
Frontiers in Pharmacology, 2023 Metabolic adaptation is an emerging hallmark of tumors. De novo fatty acid synthesis is an important metabolic process to produce metabolic intermediates for energy storage, biosynthesis of membrane lipids and generation of signaling molecules.
Yong Yu +5 more
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Changes in acetyl CoA levels during the early embryonic development of Xenopus laevis. [PDF]
PLoS ONE, 2014 Coenzyme A (CoA) is a ubiquitous and fundamental intracellular cofactor. CoA acts as a carrier of metabolically important carboxylic acids in the form of CoA thioesters and is an obligatory component of a multitude of catabolic and anabolic reactions ...
Yugo Tsuchiya +4 more
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Acetyl group coordinated progression through the catalytic cycle of an arylalkylamine N-acetyltransferase. [PDF]
PLoS ONE, 2017 The transfer of an acetyl group from acetyl-CoA to an acceptor amine is a ubiquitous biochemical transformation catalyzed by Gcn5-related N-acetyltransferases (GNATs).
Adam A Aboalroub +5 more
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Dynamic-tuning yeast storage carbohydrate improves the production of acetyl-CoA-derived chemicals
iScience, 2023 Summary: Acetyl-coenzyme A (Acetyl-CoA) and malonyl-coenzyme A (malonyl-CoA) are important precursors for producing various chemicals, and their availability affects the production of their downstream chemicals.
Chenxi Qiu +4 more
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Microbial Biotechnology, 2021 Summary The yeast Saccharomyces cerevisiae uses the pyruvate dehydrogenase‐bypass for acetyl‐CoA biosynthesis. This relatively inefficient pathway limits production potential for acetyl‐CoA‐derived biochemical due to carbon loss and the cost of two high ...
Irfan Farabi Hayat +5 more
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