Acetyl-CoA Carboxylases and Diseases
Frontiers in Oncology, 2022 Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs.
Yugang Wang
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Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan
Antioxidants, 2021 Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan extending calorie restriction (CR) decreases glucose-derived metabolic flux
Patrick Bradshaw
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Regulation of acetyl-CoA biosynthesis via an intertwined acetyl-CoA synthetase/acetyltransferase complex. [PDF]
Nat CommunAbstract Acetyl-CoA synthetase (Acs) generates acetyl-coenzyme A (Ac-CoA) but its excessive activity can deplete ATP and lead to a growth arrest. To prevent this, Acs is regulated through Ac-CoA-dependent feedback inhibition executed by Ac-CoA-dependent acetyltransferases such as AcuA in Bacillus subtilis. AcuA acetylates the catalytic lysine
Zheng L +11 more
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Truncation of LPD1 promoter and adaptive evolution increase cytosolic acetyl-CoA supply in yeast [PDF]
Synthetic and Systems BiotechnologyAcetyl-CoA is a central metabolic intermediate that serves as a key precursor for the biosynthesis of high-value compounds such as terpenoids. However, its compartmentalization within Saccharomyces cerevisiae limits its availability in the cytosol ...
Ling Qin +5 more
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Engineering yeast peroxisome assembly enables the increased production of acetyl-CoA and its derived 5-deoxyflavonoids [PDF]
Nature CommunicationsAcetyl-CoA serves as a foundational precursor and energy source for various biosynthesis pathways. The insufficient supply of acetyl-CoA in cytosol is usually a bottleneck for exogenous chemical synthesis in engineered microbes such as yeast. Exportation
Yongxing Li +3 more
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Targeting acetyl-CoA carboxylase 1 for cancer therapy
Frontiers in Pharmacology, 2023 Metabolic adaptation is an emerging hallmark of tumors. De novo fatty acid synthesis is an important metabolic process to produce metabolic intermediates for energy storage, biosynthesis of membrane lipids and generation of signaling molecules.
Yong Yu +5 more
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Changes in acetyl CoA levels during the early embryonic development of Xenopus laevis. [PDF]
PLoS ONE, 2014 Coenzyme A (CoA) is a ubiquitous and fundamental intracellular cofactor. CoA acts as a carrier of metabolically important carboxylic acids in the form of CoA thioesters and is an obligatory component of a multitude of catabolic and anabolic reactions ...
Yugo Tsuchiya +4 more
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Interaction of acetyl‐CoA fragments with rat liver acetyl‐CoA carboxylase [PDF]
European Journal of Biochemistry, 1990 The interaction of acetyl‐CoA fragments with rat liver acetyl‐CoA carboxylase has been studied. Dephosphorylated acetyl‐CoA did not actually differ from acetyl‐CoA in its substrate properties. Non‐nucleotide analogues of the substrate, S‐acetylpantatheine and it's 4′‐phosphate, also possess substrate properties (Vmax= 1.5% and 15% of the maximal rate ...
A G, Rabinkov +4 more
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Acetyl group coordinated progression through the catalytic cycle of an arylalkylamine N-acetyltransferase. [PDF]
PLoS ONE, 2017 The transfer of an acetyl group from acetyl-CoA to an acceptor amine is a ubiquitous biochemical transformation catalyzed by Gcn5-related N-acetyltransferases (GNATs).
Adam A Aboalroub +5 more
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Dynamic-tuning yeast storage carbohydrate improves the production of acetyl-CoA-derived chemicals
iScience, 2023 Summary: Acetyl-coenzyme A (Acetyl-CoA) and malonyl-coenzyme A (malonyl-CoA) are important precursors for producing various chemicals, and their availability affects the production of their downstream chemicals.
Chenxi Qiu +4 more
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