Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux
Metabolites, 2020 Acetyl-CoA is a key metabolite precursor for the biosynthesis of lipids, polyketides, isoprenoids, amino acids, and numerous other bioproducts which are used in various industries.
Jason T Ku, Ethan I Lan
exaly +4 more sources
Acetyl-CoA Carboxylases and Diseases
Frontiers in Oncology, 2022 Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs.
Yugang Wang, Weixing Yu
exaly +5 more sources
Acetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule [PDF]
Nature CommunicationsThe AMP-forming acetyl-CoA synthetase is regulated by lysine acetylation both in bacteria and eukaryotes. However, the underlying mechanism is poorly understood.
Chuan Qin +15 more
doaj +3 more sources
Regulation of acetyl-CoA biosynthesis via an intertwined acetyl-CoA synthetase/acetyltransferase complex [PDF]
Nature CommunicationsAcetyl-CoA synthetase (Acs) generates acetyl-coenzyme A (Ac-CoA) but its excessive activity can deplete ATP and lead to a growth arrest. To prevent this, Acs is regulated through Ac-CoA-dependent feedback inhibition executed by Ac-CoA-dependent ...
Liujuan Zheng +11 more
doaj +5 more sources
Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan
Antioxidants, 2021 Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan extending calorie restriction (CR) decreases glucose-derived metabolic flux
Patrick C Bradshaw
exaly +3 more sources
Truncation of LPD1 promoter and adaptive evolution increase cytosolic acetyl-CoA supply in yeast [PDF]
Synthetic and Systems BiotechnologyAcetyl-CoA is a central metabolic intermediate that serves as a key precursor for the biosynthesis of high-value compounds such as terpenoids. However, its compartmentalization within Saccharomyces cerevisiae limits its availability in the cytosol ...
Ling Qin +5 more
doaj +2 more sources
Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development
Discover Oncology, 2022 Acetyl-CoA synthetase 2 (ACSS2), an important member of the acetyl-CoA synthetase (ACSS) family, can catalyze the conversion of acetate to acetyl coenzyme A (acetyl-CoA).
Xiang Tang, Deyu Chen, Chen Gong
exaly +2 more sources
Engineering yeast peroxisome assembly enables the increased production of acetyl-CoA and its derived 5-deoxyflavonoids [PDF]
Nature CommunicationsAcetyl-CoA serves as a foundational precursor and energy source for various biosynthesis pathways. The insufficient supply of acetyl-CoA in cytosol is usually a bottleneck for exogenous chemical synthesis in engineered microbes such as yeast. Exportation
Yongxing Li +3 more
doaj +2 more sources
Targeting acetyl-CoA carboxylase 1 for cancer therapy
Frontiers in Pharmacology, 2023 Metabolic adaptation is an emerging hallmark of tumors. De novo fatty acid synthesis is an important metabolic process to produce metabolic intermediates for energy storage, biosynthesis of membrane lipids and generation of signaling molecules.
Yong Yu +5 more
doaj +1 more source
Changes in acetyl CoA levels during the early embryonic development of Xenopus laevis. [PDF]
PLoS ONE, 2014 Coenzyme A (CoA) is a ubiquitous and fundamental intracellular cofactor. CoA acts as a carrier of metabolically important carboxylic acids in the form of CoA thioesters and is an obligatory component of a multitude of catabolic and anabolic reactions ...
Yugo Tsuchiya +4 more
doaj +1 more source