Results 21 to 30 of about 214,689 (295)
Allosteric role of the citrate synthase homology domain of ATP citrate lyase
Nature Communications, 2023 ATP citrate lyase (ACLY) is the predominant nucleocytosolic source of acetyl-CoA and is aberrantly regulated in many diseases making it an attractive therapeutic target.
Xuepeng Wei +6 more
doaj +1 more source
The dynamic organization of fungal acetyl-CoA carboxylase [PDF]
, 2016 Acetyl-CoA carboxylases (ACCs) catalyse the committed step in fatty-acid biosynthesis: the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. They are important regulatory hubs for metabolic control and relevant drug targets for the treatment of ...
Hagmann, Anna +4 more
core +1 more source
Journal of Lipid Research, 1997 Transcription of acetyl-CoA carboxylase in avian liver is low during starvation or after consumption of a low-carbohydrate, high-fat diet and high during consumption of a high-carbohydrate, low-fat diet.
F B Hillgartner, T Charron
doaj +1 more source
mBio, 2016 Syntrophus aciditrophicus is a model syntrophic bacterium that degrades key intermediates in anaerobic decomposition, such as benzoate, cyclohexane-1-carboxylate, and certain fatty acids, to acetate when grown with hydrogen-/formate-consuming ...
Kimberly L. James +17 more
doaj +1 more source
, 2022 Biosynthesis of the hydroxamic acid siderophore desferrioxamine D1 (DFOD1, 6), which is the N-acetylated analogue of desferrioxamine B (DFOB, 5), has been delineated.
Renae M. Ryan (11934270) +13 more
core +1 more source
Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection
Molecules, 2017 Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) play essential roles in cell energy metabolism. Dysregulation of the biosynthesis and functioning of both compounds may contribute to various pathological conditions.
Yevgeniya I. Shurubor +7 more
doaj +1 more source
Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae. [PDF]
PLoS Genetics, 2017 Eukaryotic cells form stress granules under a variety of stresses, however the signaling pathways regulating their formation remain largely unknown. We have determined that the Saccharomyces cerevisiae lysine acetyltransferase complex NuA4 is required ...
Meaghen Rollins +7 more
doaj +1 more source
Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program
Cell Reports, 2023 Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl-CoA
Adilson Guilherme +18 more
doaj +1 more source
Regulation of purified rat liver acetyl CoA carboxylase by phosphorylation
Journal of Lipid Research, 1983 Acetyl CoA carboxylase was purified from liver of fasted-refed rats to near homogeneity, based on electrophoretic analysis and biotin content. These preparations contained an endogenous protein kinase that catalyzed the transfer of radioactive phosphate ...
J B Allred, G J Harris, J Goodson
doaj +1 more source
Exploring the Role of ATP-Citrate Lyase in the Immune System
Frontiers in Immunology, 2021 Studies over the past decade have revealed that metabolism profoundly influences immune responses. In particular, metabolism causes epigenetic regulation of gene expression, as a growing number of metabolic intermediates are substrates for histone post ...
Monica Dominguez +5 more
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