Results 11 to 20 of about 250,937 (292)

Auxin‐mediated induction of GAL promoters by conditional degradation of Mig1p improves sesquiterpene production in Saccharomyces cerevisiae with engineered acetyl‐CoA synthesis

Microbial Biotechnology, 2021
Summary The yeast Saccharomyces cerevisiae uses the pyruvate dehydrogenase‐bypass for acetyl‐CoA biosynthesis. This relatively inefficient pathway limits production potential for acetyl‐CoA‐derived biochemical due to carbon loss and the cost of two high ...
Irfan Farabi Hayat, Manuel Plan, Birgitta E. Ebert, Geoff Dumsday, Claudia E. Vickers, Bingyin Peng   +5 more
doaj   +2 more sources

Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux

Metabolites, 2020
Acetyl-CoA is a key metabolite precursor for the biosynthesis of lipids, polyketides, isoprenoids, amino acids, and numerous other bioproducts which are used in various industries.
Jason T. Ku, Arvin Y. Chen, Ethan I. Lan
doaj   +2 more sources

Acetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule [PDF]

Nature Communications
The AMP-forming acetyl-CoA synthetase is regulated by lysine acetylation both in bacteria and eukaryotes. However, the underlying mechanism is poorly understood.
Chuan Qin, Leonie G. Graf, Kilian Striska, Markus Janetzky, Norman Geist, Robin Specht, Sabrina Schulze, Gottfried J. Palm, Britta Girbardt, Babett Dörre, Leona Berndt, Stefan Kemnitz, Mark Doerr, Uwe T. Bornscheuer, Mihaela Delcea, Michael Lammers   +15 more
doaj   +2 more sources

Chemical Genetics of Acetyl-CoA Carboxylases [PDF]

Molecules, 2013
Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for herbicides in agriculture and for development of drugs for diabetes, obesity and cancers.
Xuyu Zu, Jing Zhong, Dixian Luo, Jingjing Tan, Qinghai Zhang, Ying Wu, Jianghua Liu, Renxian Cao, Gebo Wen, Deliang Cao   +9 more
openaire   +5 more sources

Chemoproteomics Yields a Selective Molecular Host for Acetyl-CoA

, 2023
Chemoproteomic profiling is a powerful approach to define the selectivity of small molecules and endogenous metabolites with the human proteome. In addition to mechanistic studies, proteome specificity profiling also has the potential to identify new ...
Zachary A. Brown (16639828), Yihang Jing, Emily Megill (16639834), McKenna C. Crawford (10966446), Jordan L. Meier, Daniel S. Kantner, Carissa Grose, Whitney K. Lieberman (16639825), Nya D. Evans, Jane E. Jones (16639840), Isita Jhulki, Jordan L. Meier (1280976), Zachary A. Brown, Daniel S. Kantner (16639831), Yihang Jing (9173722), Nathaniel W. Snyder (1282137), Emily Megill, Nya D. Evans (16639837), Nathaniel W. Snyder, McKenna C. Crawford, Isita Jhulki (2855828), Carissa Grose (4774509), Whitney K. Lieberman, Jane E. Jones   +23 more
core   +2 more sources

Metabolic engineering for efficient supply of acetyl-CoA from different carbon sources in Escherichia coli

Microbial Cell Factories, 2019
Background Acetyl-CoA is an important metabolic intermediate and serves as an acetylation precursor for the biosynthesis of various value-added acetyl-chemicals.
Shasha Zhang, Wei Yang, Hao Chen, Bo Liu, Baixue Lin, Yong Tao   +5 more
doaj   +1 more source

Allosteric role of the citrate synthase homology domain of ATP citrate lyase

Nature Communications, 2023
ATP citrate lyase (ACLY) is the predominant nucleocytosolic source of acetyl-CoA and is aberrantly regulated in many diseases making it an attractive therapeutic target.
Xuepeng Wei, Kollin Schultz, Hannah L. Pepper, Emily Megill, Austin Vogt, Nathaniel W. Snyder, Ronen Marmorstein   +6 more
doaj   +1 more source

The dynamic organization of fungal acetyl-CoA carboxylase [PDF]

, 2016
Acetyl-CoA carboxylases (ACCs) catalyse the committed step in fatty-acid biosynthesis: the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. They are important regulatory hubs for metabolic control and relevant drug targets for the treatment of ...
Hagmann, Anna, Imseng, Stefan, Hunkeler, Moritz, Stuttfeld, Edward, Maier, Timm   +4 more
core   +1 more source

Arachidonate and medium-chain fatty acids inhibit transcription of the acetyl-CoA carboxylase gene in hepatocytes in culture

Journal of Lipid Research, 1997
Transcription of acetyl-CoA carboxylase in avian liver is low during starvation or after consumption of a low-carbohydrate, high-fat diet and high during consumption of a high-carbohydrate, low-fat diet.
F B Hillgartner, T Charron
doaj   +1 more source

Diet-induced obesity impairs mammary development and lactogenesis in murine mammary gland [PDF]

, 2005
We have developed a mouse model of diet-induced obesity that shows numerous abnormalities relating to mammary gland function. Animals ate 40% more calories when offered a high-fat diet and gained weight at three times the rate of controls. They exhibited
Kelly, Paul A., Flint, David J., Travers, Maureen T., Barber, Michael C., Binart, Nadine   +4 more
core   +4 more sources