Results 31 to 40 of about 250,937 (292)

An ancient pathway combining carbon dioxide fixation with the generation and utilization of a sodium ion gradient for ATP synthesis [PDF]

, 2012
Synthesis of acetate from carbon dioxide and molecular hydrogen is considered to be the first carbon assimilation pathway on earth. It combines carbon dioxide fixation into acetyl-CoA with the production of ATP via an energized cell membrane.
Kaster, Anne-Kristin, Meike Goenrich, Gerhard Gottschalk, Schmidt, Silke, Volker Müller, Hecker, M., Schmidt, S., John Vollmers, Silke Schmidt (46446), Anja Poehlein, Andrea Thürmer, Gerhard Gottschalk (34564), Vollmers, John, Thauer, R., Thurmer, A., Goenrich, Meike, Schuchmann, Kai, Michael Hecker, Meike Goenrich (174838), Thauer, Rudolf K., Rudolf K. Thauer (174856), Volker Müller (49251), Gottschalk, G., Hecker, Michael, Müller, Volker, Gottschalk, Gerhard, Bertsch, J., Daniel, R., Muller, V., Silke Schmidt, Birgit Voigt (174853), Poehlein, Anja, Schuchmann, K., Goenrich, M., Rudolf K Thauer, Andrea Thürmer (174844), Johannes Bertsch, Anne-Kristin Kaster (174829), Rolf Daniel (113374), Bertsch, Johannes, Johannes Bertsch (174847), Vollmers, J., Birgit Voigt, Kai Schuchmann (174850), Thürmer, Andrea, John Vollmers (174842), Rolf Daniel, Daniel, Rolf, Kaster, A., Anne-Kristin Kaster, Voigt, Birgit, Kai Schuchmann, Anja Poehlein (113372), Michael Hecker (51971), Voigt, B., Poehlein, A.   +55 more
core   +1 more source

Molecular regulation of the cardiac-enriched acetyl-CoA carboxylase isoform (ACCβ) : a novel target for therapeutic interventions in cardiovascular disease [PDF]

, 2006
Includes bibliographical references (leaves 130-173).Metabolic remodeling is thought to be an important contributor towards the development of various cardiac pathophysiologic conditions.
Makaula, Siyanda S S
core   +1 more source

Metabolism of acetyl-CoA by isolated peroxisomal fractions: formation of acetate and acetoacetyl-CoA.

Journal of Lipid Research, 1991
Liver peroxisomal fractions, isolated from rats treated with clofibrate, were shown to hydrolyze added [1-14C]acetyl-CoA to free [1-14C]acetate. [1-14C]Acetyl-CoA was, however, also converted to [14C]acetoacetyl-CoA.
R Hovik, B Brodal, K Bartlett, H Osmundsen   +3 more
doaj   +1 more source

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses.

PLoS Biology, 2020
The metabolite acetyl-coenzyme A (acetyl-CoA) serves as an essential element for a wide range of cellular functions including adenosine triphosphate (ATP) production, lipid synthesis, and protein acetylation.
Ryan Houston, Shiori Sekine, Michael J Calderon, Fayaz Seifuddin, Guanghui Wang, Hiroyuki Kawagishi, Daniela A Malide, Yuesheng Li, Marjan Gucek, Mehdi Pirooznia, Alissa J Nelson, Matthew P Stokes, Jacob Stewart-Ornstein, Steven J Mullett, Stacy G Wendell, Simon C Watkins, Toren Finkel, Yusuke Sekine   +17 more
doaj   +1 more source

Profiling of cytosolic and peroxisomal acetyl-CoA metabolism in Saccharomyces cerevisiae.

PLoS ONE, 2012
As a key intracellular metabolite, acetyl-coenzyme A (acetyl-CoA) plays a major role in various metabolic pathways that link anabolism and catabolism. In the yeast Saccharomyces cerevisiae, acetyl-CoA involving metabolism is compartmentalized, and may ...
Yun Chen, Verena Siewers, Jens Nielsen
doaj   +1 more source

The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain

Frontiers in Cellular Neuroscience, 2018
Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of ...
Anna Ronowska, Andrzej Szutowicz, Hanna Bielarczyk, Sylwia Gul-Hinc, Joanna Klimaszewska-Łata, Aleksandra Dyś, Marlena Zyśk, Agnieszka Jankowska-Kulawy   +7 more
doaj   +1 more source

Novel insights into the role of acetyl-CoA producing enzymes in epigenetic regulation

Frontiers in Endocrinology, 2023
Inflammation-dependent changes in gene expression programs in innate immune cells, such as macrophages, involve extensive reprogramming of metabolism. This reprogramming is essential for the production of metabolites required for chromatin modifications,
Marta Russo, Francesco Pileri, Serena Ghisletti   +2 more
doaj   +1 more source

Comparison of Glucose, Acetate and Ethanol as Carbon Resource for Production of Poly(3-Hydroxybutyrate) and Other Acetyl-CoA Derivatives

Frontiers in Bioengineering and Biotechnology, 2020
Poly(3-hydroxybutyrate) (PHB) is a biodegradable and biocompatible thermoplastic, and synthesized from the central metabolite acetyl-CoA. The acetyl-CoA synthesis from glucose presents low atomic economy due to the release of CO2 in pyruvate ...
Shenmei Sun, Shenmei Sun, Yamei Ding, Min Liu, Mo Xian, Guang Zhao, Guang Zhao   +6 more
doaj   +1 more source

Rabbit liver acetyl-CoA synthetase [PDF]

Biochemical Journal, 1978
Acetyl-CoA synthetase (EC 6.2.1.1) was assayed in subcellular fractions of rabbit liver homogenates. The activity was located almost exclusively in the cytosol. There was no decrease in activity when butyrate or propionate (each at 5–20 mM) were added to the assay medium.
G, Woodnutt, D S, Parker
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source