Results 31 to 40 of about 214,689 (295)

Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii

BMC Biology, 2020
Background Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification.
Joachim Kloehn, Rebecca D. Oppenheim, Ghizal Siddiqui, Pieter-Jan De Bock, Sunil Kumar Dogga, Yohann Coute, Mohamed-Ali Hakimi, Darren J. Creek, Dominique Soldati-Favre   +8 more
doaj   +1 more source

Obesity, cancer and acetyl-CoA metabolism [PDF]

Drug Discovery Today: Disease Mechanisms, 2013
As rates of obesity soar in the Unites States and around the world, cancer attributed to obesity has emerged as major threat to public health. The link between obesity and cancer can be attributed in part to the state of chronic inflammation that develops in obesity.
Joyce V, Lee, Supriya A, Shah, Kathryn E, Wellen   +2 more
openaire   +2 more sources

N-acetyltaurine and Acetylcarnitine Production for the Mitochondrial Acetyl-CoA Regulation in Skeletal Muscles during Endurance Exercises

Metabolites, 2021
During endurance exercises, a large amount of mitochondrial acetyl-CoA is produced in skeletal muscles from lipids, and the excess acetyl-CoA suppresses the metabolic flux from glycolysis to the TCA cycle. This study evaluated the hypothesis that taurine
Teruo Miyazaki, Yuho Nakamura-Shinya, Kei Ebina, Shoichi Komine, Song-Gyu Ra, Keisuke Ishikura, Hajime Ohmori, Akira Honda   +7 more
doaj   +1 more source

Metabolism of acetyl-CoA by isolated peroxisomal fractions: formation of acetate and acetoacetyl-CoA.

Journal of Lipid Research, 1991
Liver peroxisomal fractions, isolated from rats treated with clofibrate, were shown to hydrolyze added [1-14C]acetyl-CoA to free [1-14C]acetate. [1-14C]Acetyl-CoA was, however, also converted to [14C]acetoacetyl-CoA.
R Hovik, B Brodal, K Bartlett, H Osmundsen   +3 more
doaj   +1 more source

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses.

PLoS Biology, 2020
The metabolite acetyl-coenzyme A (acetyl-CoA) serves as an essential element for a wide range of cellular functions including adenosine triphosphate (ATP) production, lipid synthesis, and protein acetylation.
Ryan Houston, Shiori Sekine, Michael J Calderon, Fayaz Seifuddin, Guanghui Wang, Hiroyuki Kawagishi, Daniela A Malide, Yuesheng Li, Marjan Gucek, Mehdi Pirooznia, Alissa J Nelson, Matthew P Stokes, Jacob Stewart-Ornstein, Steven J Mullett, Stacy G Wendell, Simon C Watkins, Toren Finkel, Yusuke Sekine   +17 more
doaj   +1 more source

Rabbit liver acetyl-CoA synthetase [PDF]

Biochemical Journal, 1978
Acetyl-CoA synthetase (EC 6.2.1.1) was assayed in subcellular fractions of rabbit liver homogenates. The activity was located almost exclusively in the cytosol. There was no decrease in activity when butyrate or propionate (each at 5–20 mM) were added to the assay medium.
G, Woodnutt, D S, Parker
openaire   +2 more sources

Profiling of cytosolic and peroxisomal acetyl-CoA metabolism in Saccharomyces cerevisiae.

PLoS ONE, 2012
As a key intracellular metabolite, acetyl-coenzyme A (acetyl-CoA) plays a major role in various metabolic pathways that link anabolism and catabolism. In the yeast Saccharomyces cerevisiae, acetyl-CoA involving metabolism is compartmentalized, and may ...
Yun Chen, Verena Siewers, Jens Nielsen
doaj   +1 more source

The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain

Frontiers in Cellular Neuroscience, 2018
Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of ...
Anna Ronowska, Andrzej Szutowicz, Hanna Bielarczyk, Sylwia Gul-Hinc, Joanna Klimaszewska-Łata, Aleksandra Dyś, Marlena Zyśk, Agnieszka Jankowska-Kulawy   +7 more
doaj   +1 more source

Novel insights into the role of acetyl-CoA producing enzymes in epigenetic regulation

Frontiers in Endocrinology, 2023
Inflammation-dependent changes in gene expression programs in innate immune cells, such as macrophages, involve extensive reprogramming of metabolism. This reprogramming is essential for the production of metabolites required for chromatin modifications,
Marta Russo, Francesco Pileri, Serena Ghisletti   +2 more
doaj   +1 more source

Comparison of Glucose, Acetate and Ethanol as Carbon Resource for Production of Poly(3-Hydroxybutyrate) and Other Acetyl-CoA Derivatives

Frontiers in Bioengineering and Biotechnology, 2020
Poly(3-hydroxybutyrate) (PHB) is a biodegradable and biocompatible thermoplastic, and synthesized from the central metabolite acetyl-CoA. The acetyl-CoA synthesis from glucose presents low atomic economy due to the release of CO2 in pyruvate ...
Shenmei Sun, Shenmei Sun, Yamei Ding, Min Liu, Mo Xian, Guang Zhao, Guang Zhao   +6 more
doaj   +1 more source