Results 51 to 60 of about 214,689 (295)

Acetyl-CoA steady-state levels were reduced in the TIGR4 spxB mutant.

, 2016
TIGR4 capsule consists of several sugars that are acetylated, unlike the capsule of D39. Capsule units are abbreviated: Pyr (pyruvate); Gal (galactose); ManNAc (N-acetyl-mannosamine); FucNAc (N-acetyl-fucosamine); GalNAc (N-acetyl-galactosamine); GlcA ...
Ti-Cheng Chang (39591), Jason W. Rosch (152358), Michael D. L. Johnson (189928), Charles O. Rock (364080), Amy Iverson (3227361), Haley Echlin (3227358), Matthew W. Frank (3227355)   +6 more
core   +1 more source

De novo synthesis and elongation of fatty acids by subcellular fractions of monkey aorta

Journal of Lipid Research, 1968
Subcellular fractions of aorta of squirrel monkey (Saimiri sciureus) were examined for their ability to synthesize and elongate fatty acids. High-speed supernate (HSS) incorporated substantial quantities of malonyl CoA into fatty acids while acetyl CoA ...
Charles F. Howard, Jr.
doaj   +1 more source

Herbaceous peony PlACLB2 positively regulates red petal formation by promoting anthocyanin accumulation

Frontiers in Plant Science, 2022
ATP-citrate lyase (ACL) gene catalyzes the formation of acetyl-CoA to provide intermediate precursors for many secondary metabolites, and also plays an important role in anthocyanin biosynthesis of plants.
Yuting Luan, Zijie Chen, Xin Wang, Hechen Zhang, Jun Tao, Jun Tao, Daqiu Zhao   +6 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

An ancient pathway combining carbon dioxide fixation with the generation and utilization of a sodium ion gradient for ATP synthesis

, 2012
Synthesis of acetate from carbon dioxide and molecular hydrogen is considered to be the first carbon assimilation pathway on earth. It combines carbon dioxide fixation into acetyl-CoA with the production of ATP via an energized cell membrane.
Kaster, Anne-Kristin, Meike Goenrich, Gerhard Gottschalk, Schmidt, Silke, Volker Müller, Hecker, M., Schmidt, S., John Vollmers, Silke Schmidt (46446), Anja Poehlein, Andrea Thürmer, Gerhard Gottschalk (34564), Vollmers, John, Thauer, R., Thurmer, A., Goenrich, Meike, Schuchmann, Kai, Michael Hecker, Meike Goenrich (174838), Thauer, Rudolf K., Rudolf K. Thauer (174856), Volker Müller (49251), Gottschalk, G., Hecker, Michael, Müller, Volker, Gottschalk, Gerhard, Bertsch, J., Daniel, R., Muller, V., Silke Schmidt, Birgit Voigt (174853), Poehlein, Anja, Schuchmann, K., Goenrich, M., Rudolf K Thauer, Andrea Thürmer (174844), Johannes Bertsch, Anne-Kristin Kaster (174829), Rolf Daniel (113374), Bertsch, Johannes, Johannes Bertsch (174847), Vollmers, J., Birgit Voigt, Kai Schuchmann (174850), Thürmer, Andrea, John Vollmers (174842), Rolf Daniel, Daniel, Rolf, Kaster, A., Anne-Kristin Kaster, Voigt, Birgit, Kai Schuchmann, Anja Poehlein (113372), Michael Hecker (51971), Voigt, B., Poehlein, A.   +55 more
core   +1 more source

The rocky roots of the acetyl-CoA pathway [PDF]

Trends in Biochemical Sciences, 2004
Abstract Geologists have suggested that life might have emerged at hydrothermal vents, chemists have shown that metal sulphides such as FeS and NiS can catalyse biochemical reactions in the absence of proteins, and biologists have suggested that the acetyl-coenzyme-A (CoA) pathway of CO 2 fixation might be very ancient.
Michael J, Russell, William, Martin
openaire   +2 more sources

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Graminicide insensitivity correlates with herbicide-binding co-operativity on acetyl-CoA carboxylase isoforms

, 2003
The sensitivity of grass species to important classes of graminicide herbicides inhibiting ACCase (acetyl-CoA carboxylase) is associated with a specific inhibition of the multifunctional ACCase located in the plastids of grasses.
Moss, S. R., Price, Lindsey Joanne, Harwood, J. L., Herbert, D., Moss, Stephen R., Cole, D. J., Harwood, John, Herbert, Derek, Cole, David J., Price, L. J.   +9 more
core   +1 more source

Intracellular Citrate/acetyl-CoA flux and endoplasmic reticulum acetylation: Connectivity is the answer

Molecular Metabolism, 2023
Background: Key cellular metabolites reflecting the immediate activity of metabolic enzymes as well as the functional metabolic state of intracellular organelles can act as powerful signal regulators to ensure the activation of homeostatic responses. The
Gonzalo Fernandez-Fuente, Michael J. Rigby, Luigi Puglielli   +2 more
doaj   +1 more source