Transcription shapes genome-wide histone acetylation patterns
Nature Communications, 2021 Histone acetylation is a ubiquitous hallmark of transcription. Here the authors provide evidence that the majority of histone acetylation is dependent on transcription, specifically due to the requirement of RNAPII for the recruitment and activity of ...
Benjamin J E Martin +2 more
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Temporal and spatial distribution of histone acetylation in mouse molar development [PDF]
PeerJHistone acetylation is one of the most widely studied histone modification, regulating a variety of biological activities like organ development and tumorigenesis. However, the role of histone acetylation in tooth development is poorly understood.
Wen Du +4 more
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SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape [PDF]
Nature CommunicationsSOX2 is a potent oncodriver for various squamous cancers, but the underlying mechanism is largely unknown. Here we uncover a role of SOX2 in promoting global histone acetylation in esophageal squamous cancer cells (ESCCs). Mechanistic studies reveal that
Zhen Wang +16 more
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Histone acetylation modulators in breast cancer [PDF]
Breast Cancer ResearchBreast cancer is the most prevalent cancer in women worldwide. Aberrant epigenetic reprogramming such as dysregulation of histone acetylation has been associated with the development of breast cancer.
Xueying Yuan, Jeffrey M. Rosen
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Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases
Endocrine Journal, 2023 Autoimmune thyroid diseases (AITDs), such as Graves’ disease (GD) and Hashimoto’s disease (HD), are organ-specific autoimmune diseases. Histone acetylation, especially that of histone H3, is an epigenetic mechanism that regulates gene expression and is ...
Emi Haga +8 more
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A Histone Acetylation Modulator Gene Signature for Classification and Prognosis of Breast Cancer
Current Oncology, 2021 Regulators of histone acetylation are promising epigenetic targets for therapy in breast cancer. In this study, we comprehensively analyzed the expression of histone acetylation modulator genes in breast cancer using TCGA data sources.
Mengping Long +3 more
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Small Molecules Targeting HATs, HDACs, and BRDs in Cancer Therapy
Frontiers in Oncology, 2020 Evidence for research over the past decade shows that epigenetic regulation mechanisms run through the development and prognosis of tumors. Therefore, small molecular compounds targeting epigenetic regulation have become a research hotspot in the ...
Donglu Wu +8 more
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Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. [PDF]
PLoS Biology, 2005 A major focus of current research into gene induction relates to chromatin and nucleosomal regulation, especially the significance of multiple histone modifications such as phosphorylation, acetylation, and methylation during this process.
Catherine A Hazzalin, Louis C Mahadevan
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Histone acetylation in gene regulation [PDF]
Briefings in Functional Genomics and Proteomics, 2006 Genetic information is packaged in the highly dynamic nucleoprotein structure called chromatin. Many biological processes are regulated via post-translational modifications of key proteins. Acetylation of lysine residues at the N-terminal histone tails is one of the most studied covalent modifications influencing gene regulation in eukaryotic cells ...
Verdone L +3 more
openaire +6 more sources
The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation
Cellular & Molecular Biology Letters, 2022 Canonical Wnt/β-catenin signaling is a complex cell-communication mechanism that has a central role in the progression of various cancers. The cellular factors that participate in the regulation of this signaling are still not fully elucidated.
Hongjuan You +6 more
doaj +1 more source