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Histone Acetylation and Cancer
Acta Oncologica, 2003 Acta Oncologica Vol. 42, No. 7, p. 792, 2003Received 7 March 2003Accepted 14 April 2003To the Editor:The organization of chromatin is crucial for the regulation of geneexpression. In particular, both the positioning and properties ofnucleosomes influence promoter-specific transcription in responseto extracellular or intracellular signals (1).
Kouraklis, G, Theocharis, S
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Neonatal isoflurane exposure induces neurocognitive impairment and abnormal hippocampal histone acetylation in mice. [PDF]
PLoS ONE, 2015 Neonatal exposure to isoflurane may induce long-term memory impairment in mice. Histone acetylation is an important form of chromatin modification that regulates the transcription of genes required for memory formation.
Tao Zhong +7 more
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Temporal and spatial distribution of histone acetylation in mouse molar development [PDF]
PeerJHistone acetylation is one of the most widely studied histone modification, regulating a variety of biological activities like organ development and tumorigenesis. However, the role of histone acetylation in tooth development is poorly understood.
Wen Du +4 more
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Cell Reports, 2019 Summary: Neuronal activity-inducible gene transcription correlates with rapid and transient increases in histone acetylation at promoters and enhancers of activity-regulated genes.
Liang-Fu Chen +12 more
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Frontiers in Oncology, 2022 Thyroid cancer is a common malignancy of the endocrine system, with papillary thyroid cancer (PTC) being the most common type of pathology. The incidence of PTC is increasing every year.
Chongyang Chen +2 more
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Frontiers in Immunology, 2022 BackgroundHistone acetylation modification is one of the most common epigenetic methods used to regulate chromatin structure, DNA repair, and gene expression.
Yuyan Xu +5 more
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Research progress on histone acetylation/methylation in oral diseases [PDF]
口腔疾病防治Histone acetylation and methylation can affect chromatin conformation and regulate a variety of biological activities. Abnormal histone acetylation and methylation modifications are related to the occurrence and development of a variety of oral diseases.
LUO Yuchuan, LI Feifei, YU Fanyuan, YIN Bei, YE Ling
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Simvastatin-romidepsin combination kills bladder cancer cells synergistically
Translational Oncology, 2021 The HMG-CoA reductase inhibitor simvastatin activates AMP-activated protein kinase (AMPK) and thereby induces histone acetylation. We postulated that combining simvastatin with the histone deacetylase (HDAC) inhibitor romidepsin would kill bladder cancer
Kazuki Okubo +4 more
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Molecular Genetics & Genomic Medicine, 2019 Background Neural tube defects (NTDs) are severe common birth defects that result from a failure in neural tube closure (NTC). Our previous study has shown that decreased histone methylation altered the regulation of genes linked to NTC.
Dan Li +5 more
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Histone chaperones, histone acetylation, and the fluidity of the chromogenome [PDF]
Journal of Cellular Physiology, 2010 AbstractThe “chromogenome” is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post‐translational acetylation of histones, and modulation of the chromogenome.
Jeffrey C, Hansen +3 more
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