Results 11 to 20 of about 119,811 (261)
Neonatal isoflurane exposure induces neurocognitive impairment and abnormal hippocampal histone acetylation in mice. [PDF]
PLoS ONE, 2015 Neonatal exposure to isoflurane may induce long-term memory impairment in mice. Histone acetylation is an important form of chromatin modification that regulates the transcription of genes required for memory formation.
Tao Zhong +7 more
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Temporal and spatial distribution of histone acetylation in mouse molar development [PDF]
PeerJHistone acetylation is one of the most widely studied histone modification, regulating a variety of biological activities like organ development and tumorigenesis. However, the role of histone acetylation in tooth development is poorly understood.
Wen Du +4 more
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Cell Reports, 2019 Summary: Neuronal activity-inducible gene transcription correlates with rapid and transient increases in histone acetylation at promoters and enhancers of activity-regulated genes.
Liang-Fu Chen +12 more
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Frontiers in Oncology, 2022 Thyroid cancer is a common malignancy of the endocrine system, with papillary thyroid cancer (PTC) being the most common type of pathology. The incidence of PTC is increasing every year.
Chongyang Chen +2 more
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Research progress on histone acetylation/methylation in oral diseases [PDF]
口腔疾病防治Histone acetylation and methylation can affect chromatin conformation and regulate a variety of biological activities. Abnormal histone acetylation and methylation modifications are related to the occurrence and development of a variety of oral diseases.
LUO Yuchuan, LI Feifei, YU Fanyuan, YIN Bei, YE Ling
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Frontiers in Immunology, 2022 BackgroundHistone acetylation modification is one of the most common epigenetic methods used to regulate chromatin structure, DNA repair, and gene expression.
Yuyan Xu +5 more
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Simvastatin-romidepsin combination kills bladder cancer cells synergistically
Translational Oncology, 2021 The HMG-CoA reductase inhibitor simvastatin activates AMP-activated protein kinase (AMPK) and thereby induces histone acetylation. We postulated that combining simvastatin with the histone deacetylase (HDAC) inhibitor romidepsin would kill bladder cancer
Kazuki Okubo +4 more
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Histone chaperones, histone acetylation, and the fluidity of the chromogenome [PDF]
Journal of Cellular Physiology, 2010 AbstractThe “chromogenome” is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post‐translational acetylation of histones, and modulation of the chromogenome.
Jeffrey C, Hansen +3 more
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Molecular Genetics & Genomic Medicine, 2019 Background Neural tube defects (NTDs) are severe common birth defects that result from a failure in neural tube closure (NTC). Our previous study has shown that decreased histone methylation altered the regulation of genes linked to NTC.
Dan Li +5 more
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Erasers of Histone Acetylation: The Histone Deacetylase Enzymes [PDF]
Cold Spring Harbor Perspectives in Biology, 2014 Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. In humans, there are 18 HDAC enzymes that use either zinc- or NAD(+)-dependent mechanisms to deacetylate acetyl lysine substrates.
Edward, Seto, Minoru, Yoshida
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