Results 11 to 20 of about 404,910 (338)

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase.

Immunity, 2019
Toll-like receptor (TLR) activation induces inflammatory responses in macrophages by activating temporally defined transcriptional cascades. Whether concurrent changes in the cellular metabolism that occur upon TLR activation influence the quality of the
M. Lauterbach, Jasmin Hanke, Magdalini Serefidou, M. Mangan, C. Kolbe, T. Hess, Maximilian Rothe, Romina Kaiser, Florian Hoss, J. Gehlen, G. Engels, Maike Kreutzenbeck, S. Schmidt, A. Christ, A. Imhof, Karsten Hiller, E. Latz   +16 more
semanticscholar   +3 more sources

SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape. [PDF]

Nat Commun
SOX2 is a potent oncodriver for various squamous cancers, but the underlying mechanism is largely unknown. Here we uncover a role of SOX2 in promoting global histone acetylation in esophageal squamous cancer cells (ESCCs). Mechanistic studies reveal that
Wang Z, Dai R, Kang L, Yang H, Chen Z, He J, Shu L, Zhong Y, Zhang Y, Hua Z, Huang Y, Jiang Y, Li J, Xu L, Lan F, Lin SH, Wong J.   +16 more
europepmc   +2 more sources

Histone acetylation modulators in breast cancer. [PDF]

Breast Cancer Res
Breast cancer is the most prevalent cancer in women worldwide. Aberrant epigenetic reprogramming such as dysregulation of histone acetylation has been associated with the development of breast cancer.
Yuan X, Rosen JM.
europepmc   +2 more sources

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.

Molecules and Cells, 2021
To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigenomic and transcriptomic analyses following acute inhibition of major cellular lysine acetyltransferases P300 and CBP in ...
Simon J. Hogg, Olga Motorna, Leonie A. Cluse, Timothy M. Johanson, H. Coughlan, R. Raviram, Robert M. Myers, M. Costacurta, Izabela Todorovski, Lizzy Pijpers, Stefan Bjelosevic, Tobias D. Williams, Shannon N. Huskins, C. Kearney, J. Devlin, Zheng Fan, Jafar S. Jabbari, B. Martin, M. Fareh, M. Kelly, Daphné Dupéré-Richer, J. Sandow, B. Feran, D. Knight, T. Khong, A. Spencer, S. Harrison, G. Gregory, V. Wickramasinghe, A. Webb, P. Taberlay, K. Bromberg, A. Lai, A. Papenfuss, G. Smyth, R. Allan, J. Licht, D. Landau, O. Abdel-Wahab, J. Shortt, S. Vervoort, R. Johnstone   +41 more
semanticscholar   +1 more source

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

Antioxidants, 2021
Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan extending calorie restriction (CR) decreases glucose-derived metabolic flux
P. Bradshaw
semanticscholar   +1 more source

RNA Binding to CBP Stimulates Histone Acetylation and Transcription.

Cell, 2017
D. Bose, G. Donahue, D. Reinberg, R. Shiekhattar, R. Bonasio, S. Berger   +5 more
semanticscholar   +3 more sources

Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.

Neuron, 2021
Astrocytes metabolically interact with neighboring neurons by providing multiple substances to neurons. How astrocytes regulate neural functions via altering the neuronal metabolic state remains elusive.
Xiaohui Li, Juan Zhang, Dingfeng Li, Cheng He, Keqiang He, Tian Xue, L. Wan, Chi Zhang, Qiang Liu   +8 more
semanticscholar   +1 more source

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies.

Cell Reports, 2021
Histone acetylation levels are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) that antagonistically control the overall balance of this post-translational modification.
Mariesa J Slaughter, Erin K. Shanle, Abid A Khan, Katrin F. Chua, T. Hong, Lisa D. Boxer, C. Allis, S. Josefowicz, B. Garcia, S. Rothbart, B. Strahl, I. Davis   +11 more
semanticscholar   +1 more source

Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases

Endocrine Journal, 2023
Autoimmune thyroid diseases (AITDs), such as Graves’ disease (GD) and Hashimoto’s disease (HD), are organ-specific autoimmune diseases. Histone acetylation, especially that of histone H3, is an epigenetic mechanism that regulates gene expression and is ...
Emi Haga, Naoya Inoue, Yoshinori Iwatani, Yuya Arakawa, Emi Morita, Hidemi Hashimoto, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe   +8 more
doaj   +1 more source

Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain

Molecular Neurodegeneration, 2021
Parkinson’s disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic dysregulation and specifically altered histone ...
L. Toker, Gia T Tran, J. Sundaresan, O. Tysnes, G. Alves, K. Haugarvoll, Gonzalo S. Nido, Christian Dölle, C. Tzoulis   +8 more
semanticscholar   +1 more source