Results 31 to 40 of about 119,811 (261)
Failure of long-term memory formation in juvenile snails is determined by acetylation status of histone H3 and can be improved by NaB treatment. [PDF]
PLoS ONE, 2012 BACKGROUND: Animals' capacities for different forms of learning do not mature simultaneously during ontogenesis but the molecular mechanisms behind the delayed development of specific types of memory are not fully understood.
Alexandra B Danilova +1 more
doaj +1 more source
The Role of Histone Protein Acetylation in Regulating Endothelial Function
Frontiers in Cell and Developmental Biology, 2021 Endothelial cell (EC), consisting of the innermost cellular layer of all types of vessels, is not only a barrier composer but also performing multiple functions in physiological processes.
Zhi Fang +5 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Acetylation of histones and non-histone proteins is not a mere consequence of ongoing transcription
Nature CommunicationsIn all eukaryotes, acetylation of histone lysine residues correlates with transcription activation. Whether histone acetylation is a cause or consequence of transcription is debated.
Tim Liebner +5 more
doaj +1 more source
Histone acetylation and CREB binding protein are required for neuronal resistance against ischemic injury. [PDF]
PLoS ONE, 2014 Epigenetic transcriptional regulation by histone acetylation depends on the balance between histone acetyltransferase (HAT) and deacetylase activities (HDAC).
Ferah Yildirim +10 more
doaj +1 more source
The role of altered protein acetylation in neurodegenerative disease
Frontiers in Aging Neuroscience, 2023 Acetylation is a key post-translational modification (PTM) involved in the regulation of both histone and non-histone proteins. It controls cellular processes such as DNA transcription, RNA modifications, proteostasis, aging, autophagy, regulation of ...
Fariha Kabir +4 more
doaj +1 more source
Histone acetylation in drug addiction [PDF]
Seminars in Cell & Developmental Biology, 2009 Regulation of chromatin structure through post-translational modifications of histones (e.g., acetylation) has emerged as an important mechanism to translate a variety of environmental stimuli, including drugs of abuse, into specific changes in gene expression.
William, Renthal, Eric J, Nestler
openaire +2 more sources
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Epigenetics & Chromatin, 2019 Background Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures. However, its precise mechanism remains elusive.
Chiaki Noguchi +7 more
doaj +1 more source
Biomedicines, 2023 Histone acetylation and mitochondrial function contribute importantly to neural differentiation, which is critically associated with neurodevelopmental disorders such as Down Syndrome (DS).
Yang Zhang +5 more
doaj +1 more source