Results 21 to 30 of about 116,307 (261)

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes [PDF]

Cold Spring Harbor Perspectives in Biology, 2014
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. In humans, there are 18 HDAC enzymes that use either zinc- or NAD(+)-dependent mechanisms to deacetylate acetyl lysine substrates.
Edward, Seto, Minoru, Yoshida
openaire   +2 more sources

The etiological changes of acetylation in peripheral nerve injury–induced neuropathic hypersensitivity

Molecular Pain, 2018
Neuropathic pain is a common chronic pain condition with mechanisms far clearly been elucidated. Mounting preclinical and clinical studies have shown neuropathic pain is highly associated with histone acetylation modification, which follows expression ...
Xian Wang, Xiaofeng Shen, Yingli Xu, Shiqin Xu, Fan Xia, Bei Zhu, Yusheng Liu, Wei Wang, Haibo Wu, Fuzhou Wang   +9 more
doaj   +1 more source

Total levels of hippocampal histone acetylation predict normal variability in mouse behavior.

PLoS ONE, 2014
BackgroundGenetic, pharmacological, and environmental interventions that alter total levels of histone acetylation in specific brain regions can modulate behaviors and treatment responses.
Addie May I Nesbitt, Richard D McCurdy, Sharell M Bryant, Mark D Alter   +3 more
doaj   +1 more source

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function

Cell Reports, 2019
Summary: The impact of glucose metabolism on muscle regeneration remains unresolved. We identify glucose metabolism as a crucial driver of histone acetylation and myogenic cell fate.
Nora Yucel, Yu Xin Wang, Thach Mai, Ermelinda Porpiglia, Peder J. Lund, Glenn Markov, Benjamin A. Garcia, Sean C. Bendall, Michael Angelo, Helen M. Blau   +9 more
doaj   +1 more source

Linking metabolism and histone acetylation dynamics by integrated metabolic flux analysis of Acetyl-CoA and histone acetylation sites

Molecular Metabolism
Objectives: Histone acetylation is an important epigenetic modification that regulates various biological processes and cell homeostasis. Acetyl-CoA, a hub molecule of metabolism, is the substrate for histone acetylation, thus linking metabolism with ...
Anna-Sophia Egger, Eva Rauch, Suraj Sharma, Tobias Kipura, Madlen Hotze, Thomas Mair, Alina Hohenegg, Philipp Kobler, Ines Heiland, Marcel Kwiatkowski   +9 more
doaj   +1 more source

Histone acetylation and the role of histone deacetylases in normal cyclic endometrium

Reproductive Biology and Endocrinology, 2020
Histone acetylation is a critical epigenetic modification that changes chromatin architecture and regulates gene expression by opening or closing the chromatin structure. It plays an essential role in cell cycle progression and differentiation. The human
Palak Gujral, Vishakha Mahajan, Abbey C. Lissaman, Anna P. Ponnampalam   +3 more
doaj   +1 more source

Assessment of global histone acetylation in pediatric and adolescent obesity: Correlations with SIRT1 expression and metabolic-inflammatory profiles.

PLoS ONE, 2023
BackgroundEpigenetic modifications, particularly histone acetylation-deacetylation and its related enzymes, such as sirtuin 1 (SIRT1) deacetylase, may have substantial roles in the pathogenesis of obesity and its associated health issues.
Nima Taghizadeh, Soha Mohammadi, Zeynab Yousefi, Pegah Golpour, Alemeh Taheri, Mohammad Hasan Maleki, Mitra Nourbakhsh, Mona Nourbakhsh, Maryam Razzaghy Azar   +8 more
doaj   +1 more source

NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs.

PLoS ONE, 2011
BackgroundNuclear factor (NF)-κB inducing kinase (NIK) is a central player in the non-canonical NF κB pathway, which phosphorylates IκB kinase α (IKKα) resulting in enhancement of target gene expression.
Sangwoon Chung, Isaac K Sundar, Jae-Woong Hwang, Fiona E Yull, Timothy S Blackwell, Vuokko L Kinnula, Michael Bulger, Hongwei Yao, Irfan Rahman   +8 more
doaj   +1 more source

Histone regulator KAT2A acts as a potential biomarker related to tumor microenvironment and prognosis of diffuse large B cell lymphoma

BMC Cancer, 2023
Background Recent studies have indicated that epigenetic alterations contribute significantly to lymphoma pathogenesis. A type of epigenetic regulation known as histone acetylation plays a crucial role in transcriptional regulation in eukaryotic cells ...
Zhuoya Yu, Mengfei Ding, Yiqing Cai, Tiange Lu, Xiaomin Chen, Xiangxiang Zhou, Xin Wang   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source