Results 21 to 30 of about 404,910 (338)
A Histone Acetylation Modulator Gene Signature for Classification and Prognosis of Breast Cancer
Current Oncology, 2021 Regulators of histone acetylation are promising epigenetic targets for therapy in breast cancer. In this study, we comprehensively analyzed the expression of histone acetylation modulator genes in breast cancer using TCGA data sources.
Mengping Long +3 more
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Small Molecules Targeting HATs, HDACs, and BRDs in Cancer Therapy
Frontiers in Oncology, 2020 Evidence for research over the past decade shows that epigenetic regulation mechanisms run through the development and prognosis of tumors. Therefore, small molecular compounds targeting epigenetic regulation have become a research hotspot in the ...
Donglu Wu +8 more
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Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. [PDF]
PLoS Biology, 2005 A major focus of current research into gene induction relates to chromatin and nucleosomal regulation, especially the significance of multiple histone modifications such as phosphorylation, acetylation, and methylation during this process.
Catherine A Hazzalin, Louis C Mahadevan
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The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation
Cellular & Molecular Biology Letters, 2022 Canonical Wnt/β-catenin signaling is a complex cell-communication mechanism that has a central role in the progression of various cancers. The cellular factors that participate in the regulation of this signaling are still not fully elucidated.
Hongjuan You +6 more
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Frontiers in Physiology, 2023 Skeletal muscles, the largest organ responsible for energy metabolism in most mammals, play a vital role in maintaining the body’s homeostasis.
Junjie Xu, Chenglong Li, Xiaolong Kang
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Histone deacetylase 2-mediated deacetylation of the Ribonuclease 1 promoter in inflamed human endothelial cells [PDF]
, 2020 Endothelial cells (ECs) function as protective barrier to separate the blood from the surrounding tissue by conducting crucial roles in regulation and maintenance of vascular homeostasis, such as control of vessel permeability or coagulation.
Bedenbender, Katrin
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Neonatal isoflurane exposure induces neurocognitive impairment and abnormal hippocampal histone acetylation in mice. [PDF]
PLoS ONE, 2015 Neonatal exposure to isoflurane may induce long-term memory impairment in mice. Histone acetylation is an important form of chromatin modification that regulates the transcription of genes required for memory formation.
Tao Zhong +7 more
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Determinants of a transcriptionally competent environment at the GM-CSF promoter [PDF]
, 2015 Granulocyte macrophage-colony stimulating factor (GM-CSF) is produced by T cells, but not B cells, in response to immune signals. GM-CSF gene activation in response to T-cell stimulation requires remodelling of chromatin associated with the gene ...
Brettingham-Moore, Kate H +5 more
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Histone Acetylation and Cancer
Acta Oncologica, 2003 Acta Oncologica Vol. 42, No. 7, p. 792, 2003Received 7 March 2003Accepted 14 April 2003To the Editor:The organization of chromatin is crucial for the regulation of geneexpression. In particular, both the positioning and properties ofnucleosomes influence promoter-specific transcription in responseto extracellular or intracellular signals (1).
Kouraklis, G, Theocharis, S
openaire +3 more sources