The acetyltransferase CysE modulates virulence and drug resistance of Mycobacterium tuberculosis by interfering with oxidative stress responses [PDF]
Communications BiologyAcetyltransferases play a crucial role in biological processes by modifying a variety of substrates. However, their roles in the virulence of Mycobacterium tuberculosis (M. tb) are poorly understood.
Lan-Yue Zhang +12 more
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Inhibition of Histone Lysine Acetyltransferases by Coenzyme A Analogs [PDF]
MoleculesHistone lysine acetylation is a widespread posttranslational modification, essential for vital functions in eukaryotic organisms. Histone lysine acetyltransferases (KATs) employ acetyl-coenzyme A as a universal acetyl donor for acetylation of lysine ...
Faidra Voukia +3 more
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Posttranslational regulation of the GCN5 and PCAF acetyltransferases
PLoS Genetics, 2022 General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone and non-histone proteins using acetyl coenzyme A as a donor substrate.
Onyekachi E. Ononye, Michael Downey
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Roles of histone acetylation sites in cardiac hypertrophy and heart failure
Frontiers in Cardiovascular Medicine, 2023 Heart failure results from various physiological and pathological stimuli that lead to cardiac hypertrophy. This pathological process is common in several cardiovascular diseases and ultimately leads to heart failure.
Masafumi Funamoto +3 more
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Lysine Acetyltransferases and Their Role in AR Signaling and Prostate Cancer
Frontiers in Endocrinology, 2022 The development and growth of a normal prostate gland, as well as its physiological functions, are regulated by the actions of androgens through androgen receptor (AR) signaling which drives multiple cellular processes including transcription, cellular ...
Bharti Jaiswal +2 more
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Journal of Integrative Agriculture, 2020 Histone lysine acetylation is catalyzed by acetyltransferases (HATs), which is important in regulating gene expression and physiological function in eukaryotic cells. HATs can be classified into two main types: A- and B-type HATs.
Wu-yun LÜ +5 more
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Reciprocal regulation of protein synthesis and carbon metabolism for thylakoid membrane biogenesis [PDF]
, 2013 Metabolic control of gene expression coordinates the levels of specific gene products to meet cellular demand for their activities. This control can be exerted by metabolites acting as regulatory signals and/or a class of metabolic enzymes with dual ...
Bohne, Alexandra-Viola +6 more
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Nature Communications, 2023 Acinetobacter baumannii is a nosocomial pathogen highly resistant to environmental changes and antimicrobial treatments. Regulation of cellular motility and biofilm formation is important for its virulence, although it is poorly described at the ...
Julija Armalytė +8 more
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TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases [PDF]
, 2019 The cytokine transforming growth factor β (TGFβ) plays a crucial role in the induction of both epithelial-to-mesenchymal transition (EMT) program and fibro-cirrhotic process in the liver, where it contributes also to organ inflammation following several ...
Amicone, Laura +8 more
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A synopsis of eukaryotic Nα-terminal acetyltransferases: nomenclature, subunits and substrates [PDF]
BMC Proceedings, 2009 We have introduced a consistent nomenclature for the various subunits of the NatA-NatE N-terminal acetyltransferases from yeast, humans and other eukaryotes.
Polevoda Bogdan +2 more
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