Results 1 to 10 of about 31,303 (163)

Antifungal resistance: from classical mechanisms to the expanding role of acetyltransferases [PDF]

Journal of Biomedical Science
Antifungal resistance represents a growing global health challenge, driven by limited therapeutic options, inadequate use of both clinical and environmental drugs, and the remarkable adaptive capacity of fungal pathogens. While resistance has classically
Silvia Maria Cordeiro Werneck, Ludmila Gouveia-Eufrasio, Gustavo José Cota de Freitas, Daniel Santana de Carvalho, Isabela da Costa César, Luana Rossato, Rafael Wesley Bastos, Nalu Teixeira Aguiar Peres, Daniel Assis Santos   +8 more
doaj   +2 more sources

Garcinol and Anacardic Acid, Natural Inhibitors of Histone Acetyltransferases, Inhibit Rhabdomyosarcoma Growth and Proliferation

Molecules, 2023
Rhabdomyosarcoma (RMS) is a malignant tumour of the soft tissues. There are two main histopathological types: alveolar and embryonal. RMS occurs mainly in childhood and is a result of the deregulation of growth and differentiation of muscle cell ...
Dorota Rogińska, Magdalena Perużyńska, Maciej Tarnowski   +2 more
exaly   +3 more sources

Hierarchical small molecule inhibition of MYST acetyltransferases [PDF]

Nature Communications
MYST lysine acetyltransferases (KATs) are a class of epigenetic enzymes critical for cellular function that constitute an emerging therapeutic target in cancer.
Xuemin Chen, Alexandra Castroverde, Minervo Perez, Ronald Holewinski, Kiall F. Suazo, Rashmi Karki, Thorkell Andresson, Benjamin A. Garcia, Jordan L. Meier   +8 more
doaj   +2 more sources

Inhibition of Histone Lysine Acetyltransferases by Coenzyme A Analogs [PDF]

Molecules
Histone lysine acetylation is a widespread posttranslational modification, essential for vital functions in eukaryotic organisms. Histone lysine acetyltransferases (KATs) employ acetyl-coenzyme A as a universal acetyl donor for acetylation of lysine ...
Faidra Voukia, Nurgül Bilgin, Steffen Bundgaard Andersen, Jasmin Mecinović   +3 more
doaj   +2 more sources

Posttranslational regulation of the GCN5 and PCAF acetyltransferases

PLoS Genetics, 2022
General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone and non-histone proteins using acetyl coenzyme A as a donor substrate.
Onyekachi E. Ononye, Michael Downey
doaj   +2 more sources

Roles of histone acetylation sites in cardiac hypertrophy and heart failure

Frontiers in Cardiovascular Medicine, 2023
Heart failure results from various physiological and pathological stimuli that lead to cardiac hypertrophy. This pathological process is common in several cardiovascular diseases and ultimately leads to heart failure.
Masafumi Funamoto, Masaki Imanishi, Koichiro Tsuchiya, Yasumasa Ikeda   +3 more
doaj   +1 more source

Lysine Acetyltransferases and Their Role in AR Signaling and Prostate Cancer

Frontiers in Endocrinology, 2022
The development and growth of a normal prostate gland, as well as its physiological functions, are regulated by the actions of androgens through androgen receptor (AR) signaling which drives multiple cellular processes including transcription, cellular ...
Bharti Jaiswal, Akanksha Agarwal, Ashish Gupta   +2 more
doaj   +1 more source

FgHAT2 is involved in regulating vegetative growth, conidiation, DNA damage repair, DON production and virulence in Fusarium graminearum

Journal of Integrative Agriculture, 2020
Histone lysine acetylation is catalyzed by acetyltransferases (HATs), which is important in regulating gene expression and physiological function in eukaryotic cells. HATs can be classified into two main types: A- and B-type HATs.
Wu-yun LÜ, Nan YANG, Zhe XU, Han DAI, Shuai TANG, Zheng-yi WANG   +5 more
doaj   +1 more source

The BRCA2 is a histone acetyltransferase [PDF]

Oncogene, 1998
Patients carrying mutations in BRCA1 or BRCA2 tumor suppressor genes have shown to have high risk in developing breast and ovarian cancers. Two potential functions of BRCA2 were proposed which includes role in the regulation of transcription and also in DNA repair.
H, Siddique, J P, Zou, V N, Rao, E S, Reddy   +3 more
openaire   +2 more sources

A polyamine acetyltransferase regulates the motility and biofilm formation of Acinetobacter baumannii

Nature Communications, 2023
Acinetobacter baumannii is a nosocomial pathogen highly resistant to environmental changes and antimicrobial treatments. Regulation of cellular motility and biofilm formation is important for its virulence, although it is poorly described at the ...
Julija Armalytė, Albinas Čepauskas, Gabija Šakalytė, Julius Martinkus, Jūratė Skerniškytė, Chloé Martens, Edita Sužiedėlienė, Abel Garcia-Pino, Dukas Jurėnas   +8 more
doaj   +1 more source