Results 21 to 30 of about 35,074 (278)
Polyglutamine Disease: Acetyltransferases Awry [PDF]
, 2002 Recent evidence indicates that inhibition of histone acetyltransferases may be a primary cause of cellular pathogenesis in polyglutamine diseases such as Huntington disease; the results raise the possibility that pharmacologic manipulation of protein ...
Hughes, Robert E., Robert E. Hughes
core +1 more source
Investigations of N-acetyltransferases in human hepatocytes and rat models. [PDF]
, 2005 This thesis begins by reviewing human N-acetyltransferases (Chapter I), then outlines experiments involving human hepatocytes and rat N-acetyltransferases (Chapters II-V).
Walraven, Jason Matthew
core +1 more source
Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme
IUCrJ, 2014 Capsular polysaccharides (CPSs) are protective structures on the surfaces of many Gram-negative bacteria. The principal CPS of the human pathogen and Tier 1 select agent Burkholderia pseudomallei consists of a linear repeat of –3)-2-O-acetyl-6-deoxy-β-d ...
Mirella Vivoli +4 more
doaj +1 more source
Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals [PDF]
, 2018 Histone acetylation has been recognized as an important post-translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair.
Thomas, T, Voss, AK
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Regulating histone acetyltransferases and deacetylases [PDF]
, 2003 Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated
Trouche, Didier +3 more
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Communications Biology, 2022 A comprehensive functional and structural study of the Antibiotic_NAT family of aminoglycoside acetyltransferases provides new insight into the molecular mechanisms underlying resistance to existing and emerging aminoglycoside antibiotics.
Peter J. Stogios +11 more
doaj +1 more source
Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]
, 2005 The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Eberharter, Anton +2 more
core +1 more source
PLoS ONE, 2014 An important cause of bacterial resistance to aminoglycoside antibiotics is the enzymatic acetylation of their amino groups by acetyltransferases, which abolishes their binding to and inhibition of the bacterial ribosome. Enhanced intracellular survival (
Oleg V Tsodikov +2 more
doaj +1 more source
MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain
Nature Communications, 2023 Human acetyltransferases MOZ and MORF mediate development programs and are dysregulated in diseases. Here the authors identified two winged helix (WH) domains in MORF/MOZ and characterized their DNA binding functions, including targeting of CpG by WH1.
Dustin C. Becht +18 more
doaj +1 more source
Posttranslational modifications of Gcn5-like acetyltransferases in yeast and mammalian cells.
, 2022 Posttranslational modifications of Gcn5-like acetyltransferases in yeast and mammalian cells.
Michael Downey (6838643) +1 more
core +1 more source