Results 41 to 50 of about 35,074 (278)

Regulation of Histone Acetyltransferases p300 and PCAF by the bHLH Protein Twist and Adenoviral Oncoprotein E1A [PDF]

, 1999
Histone acetyltransferases (HAT) play a critical role in transcriptional control by relieving repressive effects of chromatin, and yet how HATs themselves are regulated remains largely unknown.
Wu, Hung-Yi, Ogryzko, Vasily, Sartorelli, Vittorio, Puri, Pier Lorenzo, Nakatani, Yoshihiro, Hamamori, Yasuo, Wang, Jean Y.J, Kedes, Larry   +7 more
core   +1 more source

Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer

Stem Cells International, 2018
Protein acetylation is one of the most important posttranslational modifications catalyzed by acetyltransferases and deacetylases, through the addition and removal of acetyl groups to lysine residues. Lysine acetylation can affect protein-nucleic acid or
Daniela Trisciuoglio, Marta Di Martile, Donatella Del Bufalo   +2 more
doaj   +1 more source

Review: Acetylation mechanisms and targeted therapies in cardiac fibrosis

Pharmacological Research, 2023
Cardiac fibrosis is a common pathophysiological remodeling process that occurs in a variety of cardiovascular diseases and greatly influences heart structure and function, progressively leading to the development of heart failure.
Weikang Liu, Qiuhuan Yuan, Shengchuan Cao, Guoying Wang, Xiangguo Liu, Yanan Xia, Yuan Bian, Feng Xu, Yuguo Chen   +8 more
doaj   +1 more source

NAT1 (N-acetyltransferase 1 (arylamine N-acetyltransferase)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on NAT1 (N-acetyltransferase 1 (arylamine N-acetyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ruiz, JD, Agúndez, JAG, Martínez, C, García-Martín, E   +3 more
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Expression of cPLAγ mRNA and protein differs the response of PBMC from severe and non-severe asthmatics to bacterial lipopolysaccharide and house dust mite allergen

International Journal of Immunopathology and Pharmacology, 2021
Chronic inflammation in asthmatics is initiated/exacerbated by many environmental factors, such as bacterial lipopolysaccharide and allergens. Phospholipase A 2 and histone acetyltransferase/deacetylases are enzymes involved in inflammatory process ...
Ewa Pniewska-Dawidczyk, Izabela Kupryś-Lipińska, Gabriela Turek, Dorota Kacprzak, Joanna Wieczfinska, Paulina Kleniewska, Piotr Kuna, Rafal Pawliczak   +7 more
doaj   +1 more source

NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ruiz, JD, Agúndez, JAG, Martínez, C, García-Martín, E   +3 more
openaire   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source