Results 1 to 10 of about 13,476,144 (183)

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages. [PDF]

PLoS ONE, 2012
Latent M. tuberculosis infection presents one of the major obstacles in the global eradication of tuberculosis (TB). Cholesterol plays a critical role in the persistence of M. tuberculosis within the macrophage during latent infection.
Areej Abuhammad, Elizabeth Fullam, Edward D Lowe, David Staunton, Akane Kawamura, Isaac M Westwood, Sanjib Bhakta, Alun Christopher Garner, David L Wilson, Peter T Seden, Stephen G Davies, Angela J Russell, Elspeth F Garman, Edith Sim   +13 more
doaj   +3 more sources

Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability. [PDF]

PLoS ONE, 2018
Human arylamine N-acetyltransferase 1 (NAT1) has been associated with cancer cell growth and invasion, but the underlying molecular mechanisms remain unknown.
LiLi Wang, Rodney F Minchin, Neville J Butcher   +2 more
doaj   +2 more sources

Clinical Function Assignment of NAT2 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel [PDF]

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1101-1110, October 2026.
NAT2 encodes arylamine N‐acetyltransferase 2, a key enzyme in the phase II metabolism of arylamines and arylhydrazines. NAT2 is highly polymorphic, resulting in variable distributions of rapid and poor metabolizers across global populations. Here, we detail the process undertaken by the Clinical Pharmacogenetics Implementation Consortium (CPIC) NAT2 ...
Bailey M. Tibben, David W. Hein, Michelle Whirl‐Carrillo, Andrea Gaedigk, Michael T. Eadon, Rodney F. Minchin, Sotiria Boukouvala, Adalberto Rezende Santos, Roseann S. Donnelly, José A. G. Agúndez, Kelly E. Caudle   +10 more
wiley   +2 more sources

Neonatal Ontogeny of Murine Arylamine N-Acetyltransferases: Implications for Arylamine Genotoxicity [PDF]

Toxicological Sciences, 2003
Age-related changes in the expression of xenobiotic biotransformation enzymes can result in differences in the rates of chemical activation and detoxification, affecting responses to the therapeutic and/or toxic effects of chemicals. Despite recognition that children and adults may exhibit differences in susceptibility to chemicals, information about ...
Charlene A, McQueen, Binh, Chau
openaire   +2 more sources

The distribution of allelic and genotypic frequencies of N-Acetyltransferase-2 variants in an Argentine population

Journal of Infection in Developing Countries, 2012
Introduction: Arylamine N-acetyltransferase-2 (NAT-2) is a key human enzyme in drug detoxification and elimination. Mutations in NAT-2 affect the activity of anti-tuberculosis drugs and result in three different phenotypes: rapid (RA), intermediate (IA)
Julián Gabriel Chamorro, Jorge P Castagnino, Rosa M Musella, Ana Frias, Federico Manuel Aranda, Gabriela Fernanda de Larrañaga   +5 more
doaj   +1 more source

NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review

PLoS ONE, 2023
Arylamine N-acetyltransferase 2 has been related to drug side effects and cancer susceptibility; its protein structure and acetylation capacity results from the polymorphism’s arrays on the NAT2 gene.
Jorge E. Gutiérrez-Virgen, Maricela Piña-Pozas, Esther A. Hernández-Tobías, Lucia Taja-Chayeb, Ma. de Lourdes López-González, Marco A. Meraz-Ríos, Rocío Gómez   +6 more
doaj   +2 more sources

5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. [PDF]

PLoS ONE, 2013
Folate catabolism involves cleavage of the C(9)-N(10) bond to form p-aminobenzoylgluamate (PABG) and pterin. PABG is then acetylated by human arylamine N-acetyltransferase 1 (NAT1) before excretion in the urine.
Katey L Witham, Neville J Butcher, Kim S Sugamori, Debbie Brenneman, Denis M Grant, Rodney F Minchin   +5 more
doaj   +1 more source

Pharmacokinetics of isoniazid and rifapentine in young pediatric patients with latent tuberculosis infection

International Journal of Infectious Diseases, 2022
Objectives: This study investigated the steady-state pharmacokinetic profiles of 3-month weekly rifapentine plus isoniazid (3HP) in children with latent tuberculosisinfection (LTBI).
Weeraya Phaisal, Watsamon Jantarabenjakul, Noppadol Wacharachaisurapol, Monta Tawan, Thanyawee Puthanakit, Supeecha Wittayalertpanya, Pajaree Chariyavilaskul   +6 more
doaj   +1 more source

Environmental Pesticide Exposure in the Etiology of Pediatric Brain Tumors and Leukemia: A Scoping Review of Epidemiological Studies

International Journal of Cancer, Volume 159, Issue 6, Page 1360-1384, 15 September 2026.
ABSTRACT Pediatric cancer is a significant cause of morbidity and mortality in children. The etiologies of pediatric cancer are largely unknown, but environmental pesticide exposures are likely to contribute. Chronic low‐dose exposure to pesticide mixtures through drinking water is a growing concern in agricultural communities.
Grace N. VanDeSteeg, Alyssa R. Russum, Matthew R. Sandbulte, Eleanor G. Rogan, Martha G. Rhoades   +4 more
wiley   +1 more source

Genetic Variants at the NAT2 and HLA‐DOA are Associated With Anti‐Tuberculosis Drug‐Induced Liver Injury Susceptibility and Clinical Manifestations in Western Chinese Populations

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Background Anti‐tuberculosis drug‐induced liver injury (ATDILI) is one of the most prevalent and serious adverse reactions during anti‐tuberculosis treatment and can potentially lead to liver failure or mortality. This study aims to investigate whether genetic variants in the N‐acetyltransferase 2 gene (NAT2) and the HLA‐DOA gene (HLA‐DOA) are
Zhenzhen Zhao, Dongmei Wang, Yanjun Si, Yanhong Zhou, Hongxia Ruan, Binwu Ying, Hao Chen   +6 more
wiley   +1 more source