Results 1 to 10 of about 3,328,553 (209)

Factores genéticos y ambientales asociados con la respuesta a warfarina en pacientes colombianos

Biomédica: revista del Instituto Nacional de Salud, 2010
Introducción. La warfarina es un anticoagulante de difícil manejo por su estrecho margen terapéutico y los numerosos factores que influyen en la respuesta. Objetivo.
Carlos Isaza, Leonardo Beltrán, Julieta Henao, Gloria Porras, Alfredo Pinzón, Álvaro Vallejos, Jorge Machado   +6 more
doaj   +1 more source

Angiotensin II type 1 receptor gene polymorphism could influence renoprotective response to losartan treatment in type 1 diabetic patients with high urinary albumin excretion rate [PDF]

Vojnosanitetski Pregled, 2010
Background/Aim. Diabetic nephropathy (DN) is a clinical syndrome characterized by persistent albuminuria, increasing arterial blood pressure and progressive decline in glomerular filtration rate (GFR).
Dragović Tamara, Ajdinović Boris, Hrvačević Rajko, Ilić Vesna, Magić Zvonko, Anđelković Zoran, Kocev Nikola   +6 more
doaj   +1 more source

Identificación de tres nuevas mutaciones en el gen RB1 en pacientes con retinoblastoma esporádico en Colombia

Biomédica: revista del Instituto Nacional de Salud, 2013
Introducción. El retinoblastoma es un cáncer pediátrico de la retina originado por la expresión alterada o ausente de la proteína del retinoblastoma (pRb).
Martha Lucía Serrano, Juan José Yunis
doaj   +1 more source

The c.-1639g>A polymorphism of the VKORC1 gene and his influence on the therapeutic response during oral anticoagulants use [PDF]

Vojnosanitetski Pregled, 2009
Background/Aim. A single nucleotide polymorphism c.- 1639G>A in the promoter region of vitamin K-epoxide reductase (VKORC1) gene has been found to account for most of the variability in response to oral anticoagulants (OA). The aim of the study was to
Kovač Mirjana, Rakićević Ljiljana, Maslać Aleksandar, Radojković Dragica   +3 more
doaj   +1 more source

Evidencia de asociación entre el gen SLC6A4 y efectos epistáticos con variantes en HTR2A en la etiología del autismo en la población antioqueña

Biomédica: revista del Instituto Nacional de Salud, 2012
Introducción. El espectro autista constituye un grupo de trastornos graves del neurodesarrollo, conun fuerte componente genético. Se ha sugerido un papel importante del sistema serotoninérgico en el desarrollo de este grupo de trastornos, con base en los
Ana Victoria Valencia, Ana Lucía Páez, María Elena Sampedro, Clara Ávila, Julio Cesar Cardona, Catalina Mesa, Lina Galvis, Jaime Carrizosa, Mauricio Camargo, Andrés Ruíz, William Cornejo, Gabriel Bedoya   +11 more
doaj   +1 more source

Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome

Biomédica: revista del Instituto Nacional de Salud
Introduction. Multiple genetic and environmental factors interact with the development of acute coronary syndrome. Smoking is one of the environmental factors that might alter the metabolic pathways shared by genes associated with this condition ...
Liliana Franco, Natalia Gallego, Cristian Velarde, Diana Valencia, Juan Pablo Pérez-Bedoya, Kelly Betancur, Kelly Marisancen, Paola Parra, Santiago Carvalho, Luisa Parra, Evert Jiménez, Carlos Martínez, Clara Saldarriaga, Juan Carlos Arango, Nathalia González-Jaramillo, Jenny García, Ana Valencia   +16 more
doaj   +1 more source

Impact of Sociodemographic, Clinical, and Genetic Factors and Fusobacterium nucleatum on Premature Birth Outcomes in Women from Kazakhstan: A Case-Control Study [PDF]

Iranian Journal of Medical Sciences
Background: Premature birth (delivery before 37 weeks of gestation) is a leading cause of neonatal morbidity and mortality worldwide. Specific genetic polymorphisms were associated with immune and inflammatory pathways that might contribute to its ...
Gulmira Zhurabekova, Aru Balmagambetova, Zhibek Oralkhan, Maygul Sarsenova, Guliya Toichiyeva, Nazym Altynbay, Azhar Malik, Kuanysh Tastambek, Akzhenis Berdalinova   +8 more
doaj   +1 more source

Association between Val158Met COMT, TNF-α -857 C>T, TNFR1 36 A>G, IL-1α 4845 G>T and IL-10 -1082 A>G polymorphisms and risk of early-onset preeclampsia and its complications [PDF]

Vojnosanitetski Pregled, 2017
Background/Aim. Preeclampsia (PE) belongs to the group of hypertensive disorders in pregnancy with the global average incidence of 2.16%. It is considered as one of the leading causes of maternal and neonatal morbidity and mortality worldwide.
Krnjeta Tijana, Mirković Ljiljana, Ignjatović Svetlana, Tomšević Dragana, Lukić Jelena, Topalov Drina, Majkić-Singh Nada   +6 more
doaj   +1 more source

Rapid SNP Discovery and Genetic Mapping Using Sequenced RAD Markers

PLoS ONE, 2008
Single nucleotide polymorphism (SNP) discovery and genotyping are essential to genetic mapping. There remains a need for a simple, inexpensive platform that allows high-density SNP discovery and genotyping in large populations.
N. Baird, Paul D. Etter, T. S. Atwood, M. Currey, A. Shiver, Zachary A. Lewis, E. Selker, W. Cresko, Eric A. Johnson   +8 more
semanticscholar   +1 more source

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism

Nature, 2015
Neuroblastoma is a paediatric malignancy that typically arises in early childhood, and is derived from the developing sympathetic nervous system. Clinical phenotypes range from localized tumours with excellent outcomes to widely metastatic disease in ...
D. Oldridge, A. Wood, Nina Weichert-Leahey, Ian Crimmins, Robyn T. Sussman, C. Winter, L. McDaniel, M. Diamond, Lori S. Hart, Shizhen Zhu, A. Durbin, B. Abraham, L. Anders, Lifeng Tian, Shile Zhang, Jun S. Wei, J. Khan, K. Bramlett, N. Rahman, M. Capasso, A. Iolascon, D. Gerhard, Jaime M Guidry Auvil, R. Young, H. Hakonarson, S. Diskin, A. Look, J. Maris   +27 more
semanticscholar   +1 more source