Results 1 to 10 of about 46,119 (273)

Pharmacogenetics and Forensic Toxicology: A New Step towards a Multidisciplinary Approach

Toxics, 2021
Pharmacogenetics analyzes the individual behavior of DNA genes after the administration of a drug. Pharmacogenetic research has been implemented in recent years thanks to the improvement in genome sequencing techniques and molecular genetics. In addition
Nunzio Di Nunno, Massimiliano Esposito, Antonina Argo, Monica Salerno, Francesco Sessa   +4 more
doaj   +2 more sources

From pharmacogenetics to pharmaco-omics: Milestones and future directions

HGG Advances, 2022
The origins of pharmacogenetics date back to the 1950s, when it was established that inter-individual differences in drug response are partially determined by genetic factors.
Chiara Auwerx, Marie C. Sadler, Alexandre Reymond, Zoltán Kutalik   +3 more
doaj   +2 more sources

Knowledge, perceptions and confidence of physicians and pharmacists towards pharmacogenetics practice in Kuwait [PDF]

PLoS ONE, 2018
BACKGROUND:Pharmacogenetics practice has been successfully implemented in many developed countries to enhance personalized medicine and improve clinical and economic outcomes.
Abdullah Albassam, Abdelmoneim Awad, Samuel Koshy   +2 more
exaly   +2 more sources

Inconsistency in race and ethnic classification in pharmacogenetics studies and its potential clinical implications

Pharmacogenomics and Personalized Medicine, 2019
Frederick Zhang,1 Joseph Finkelstein21Center for Bioinformatics and Data Analytics, Columbia University Irving Medical Center, New York, NY, USA; 2Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY ...
Zhang F, Finkelstein J
doaj   +2 more sources

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants

Clinical pharmacology and therapy, 2023
Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake inhibitors (SSRIs; i.e., citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline), serotonin and norepinephrine reuptake inhibitors (i.e ...
C. Bousman, J. Stevenson, L. Ramsey, K. Sangkuhl, J. K. Hicks, J. Strawn, Ajeet B Singh, G. Ruaño, D. J. Mueller, Evangelia Eirini Tsermpini, Jacob T Brown, G. Bell, J. S. Leeder, A. Gaedigk, Stuart A. Scott, T. Klein, K. Caudle, J. Bishop   +17 more
semanticscholar   +1 more source

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update

Clinical pharmacology and therapy, 2022
CYP2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19 genotype impacts clopidogrel active metabolite formation. CYP2C19 intermediate and poor metabolizers who receive clopidogrel experience reduced platelet inhibition ...
Craig R. Lee, Jasmine A. Luzum, K. Sangkuhl, Roseann S. Gammal, M. Sabatine, C. Stein, D. Kisor, N. Limdi, Yee Ming Lee, S. Scott, J. Hulot, D. Roden, A. Gaedigk, K. Caudle, T. Klein, Julie A. Johnson, A. Shuldiner   +16 more
semanticscholar   +1 more source

Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6, OPRM1, and COMT genotype and select opioid therapy

Clinical pharmacology and therapy, 2021
Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone).
K. Crews, A. Monte, Rachel Huddart, K. Caudle, E. Kharasch, A. Gaedigk, H. M. Dunnenberger, J. S. Leeder, J. Callaghan, C. Samer, T. Klein, Cyrine E. Haidar, S. V. Van Driest, G. Ruaño, K. Sangkuhl, L. Cavallari, D. Müller, C. Prows, M. Nagy, A. Somogyi, T. Skaar   +20 more
semanticscholar   +1 more source

The Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for SLCO1B1, ABCG2, and CYP2C9 and statin-associated musculoskeletal symptoms

Clinical pharmacology and therapy, 2022
Statins reduce cholesterol, prevent cardiovascular disease, and are among the most commonly prescribed medications in the world. Statin‐associated musculoskeletal symptoms (SAMS) impact statin adherence and ultimately can impede the long‐term ...
R. Cooper-DeHoff, M. Niemi, L. Ramsey, Jasmine A. Luzum, E. Tarkiainen, R. Straka, L. Gong, S. Tuteja, R. Wilke, M. Wadelius, Eric A. Larson, D. Roden, T. Klein, S. Yee, R. Krauss, R. Turner, L. Palaniappan, A. Gaedigk, K. Giacomini, K. Caudle, D. Voora   +20 more
semanticscholar   +1 more source

Cost Effectiveness of Pharmacogenetic Testing for Drugs with Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines: A Systematic Review

Clinical pharmacology and therapy, 2022
The objective of this study was to evaluate the evidence on cost‐effectiveness of pharmacogenetic (PGx)–guided treatment for drugs with Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines.
Sarah A. Morris, A. Alsaidi, Allison Verbyla, Adilen Cruz, Casey Macfarlane, J. Bauer, J. Patel   +6 more
semanticscholar   +1 more source

The Role of Pharmacogenetics in Personalizing the Antidepressant and Anxiolytic Therapy

Genes, 2023
Pharmacotherapy for neuropsychiatric disorders, such as anxiety and depression, has been characterized by significant inter-individual variability in drug response and the development of side effects.
Milica Radosavljevic, D. Švob Štrac, J. Jančić, J. Samardžić   +3 more
semanticscholar   +1 more source