Results 1 to 10 of about 30,618 (276)

An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy

Nature Communications, 2016
The use of immunostimulatory agents to enhance the efficacy of chemotherapy is a promising strategy in cancer therapy. Here, the authors report on a micellar nanoparticle that can effectively co-deliver chemo- and immunotherapeutics, resulting in an ...
Yichao Chen, Rui Xia, Yixian Huang, Wenchen Zhao, Jiang Li, Xiaolan Zhang, Pengcheng Wang, Raman Venkataramanan, Jie Fan, Wen Xie, Xiaochao Ma, Binfeng Lu, Song Li   +12 more
doaj   +1 more source

Chronic Activation of LXRα Sensitizes Mice to Hepatocellular Carcinoma

Hepatology Communications, 2022
The oxysterol receptor liver X receptor (LXR) is a nuclear receptor best known for its function in the regulation of lipid and cholesterol metabolism.
Yang Xie, Runzi Sun, Li Gao, Jibin Guan, Jingyuan Wang, Aaron Bell, Junjie Zhu, Min Zhang, Meishu Xu, Peipei Lu, Xinran Cai, Songrong Ren, Pengfei Xu, Satdarshan P. Monga, Xiaochao Ma, Da Yang, Yulan Liu, Binfeng Lu, Wen Xie   +18 more
doaj   +1 more source

Pharmacogenetics, pharmacogenomics and airway disease [PDF]

, 2001
The availability of a draft sequence for the human genome will revolutionise research into airway disease. This review deals with two of the most important areas impinging on the treatment of patients: pharmacogenetics and pharmacogenomics.
Ian P Hall, Hall, Ian P., Hall Ian P
core   +1 more source

Systematic investigation of chemo-immunotherapy synergism to shift anti-PD-1 resistance in cancer

Nature Communications
Chemo-immunotherapy combinations have been regarded as one of the most practical ways to improve immunotherapy response in cancer patients. In this study, we integrate the transcriptomics data from anti-PD-1-treated tumors and compound-treated cancer ...
Yue Wang, Dhamotharan Pattarayan, Haozhe Huang, Yueshan Zhao, Sihan Li, Yifei Wang, Min Zhang, Song Li, Da Yang   +8 more
doaj   +1 more source

The Role of CTGF in Liver Fibrosis Induced in 3D Human Liver Spheroids

Cells, 2023
Connective tissue growth factor (CTGF) is involved in the regulation of extracellular matrix (ECM) production. Elevated levels of CTGF can be found in plasma from patients with liver fibrosis and in experimental animal models of liver fibrosis, but the ...
Sara Redenšek Trampuž, Sander van Riet, Åsa Nordling, Magnus Ingelman-Sundberg   +3 more
doaj   +1 more source

Atypical functions of xenobiotic receptors in lipid and glucose metabolism

Medical Review, 2022
Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors, the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and disposition of xenobiotics.
Wang Jingyuan, Lu Peipei, Xie Wen
doaj   +1 more source

Pharmacogenetics: ethical issues

, 2003
abstrac
Thomas, S.
core   +3 more sources

Pharmacogenetics of antidepressant response: An update

Human Genomics, 2009
The past few decades have witnessed much progress in the field of pharmacogenetics. The identification of the genetic background that regulates the antidepressant response has benefited from these advances.
Drago Antonio, De Ronchi Diana, Serretti Alessandro   +2 more
doaj   +1 more source

Pharmacogenetic testing: current state of the issue

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Aim. The purpose of this work is to emphasize the importance and practical benefits of pharmacogenetics in medicine, demonstrating how the integration of pharmacogenetics into clinical practice can improve treatment outcomes and enhance the safety of ...
O. V. Kraidashenko, O. O. Kremzer, T. O. Samura   +2 more
doaj   +1 more source

CLOPIDOGREL PHARMACOGENETICS

Рациональная фармакотерапия в кардиологии, 2016
Platelets play an important role in the pathogenesis of atherosclerosis. They are involved in atherosclerosis progression and thrombotic complications. That is why antiplatelet therapy is a necessary element of these complications prevention in patients ...
A. N. Meshkov
doaj   +1 more source