Results 1 to 10 of about 57,996 (259)

Drug-gene interactions of antihypertensive medications and risk of incident cardiovascular disease: a pharmacogenomics study from the CHARGE consortium [PDF]

, 2015
Background Hypertension is a major risk factor for a spectrum of cardiovascular diseases (CVD), including myocardial infarction, sudden death, and stroke.
Arnett, Donna, Avery, Christy L., Bis, Joshua C., Boerwinkle, Eric, Brody, Jennifer A., Buckley, Brendan M., Chen, Yii-Der Ida, Cummings, Steven R., Cupples, L. Adrienne, Davis, Barry R., de Craen, Anton J. M., Demissie, Serkalem, Eckfeldt, John H., Evans, Daniel S., Ford, Ian, Franco, Oscar H., Gudnason, Vilmundur, Harris, Tamara B., Heckbert, Susan R., Hofman, Albert, Ikram, M. Arfan, Irvin, Ryan, Jukema, J. Wouter, Krijthe, Bouwe P., Lange, Leslie A., Launer, Lenore J., Li, Xiaohui, Liu, Yongmei, Lumley, Thomas, Musani, Solomon K., Post, Wendy, Psaty, Bruce M., Quibrera, P. Miguel, Rotter, Jerome I., Sattar, Naveed, Sitlani, Colleen, Slagboom, P. Eline, Smith, Albert Vernon, Smith, Nicholas L., Sotoodehnia, Nona, Stott, David J., Stricker, Bruno H., Stürmer, Til, Sun, Fangui, Taylor, Herman A., Taylor, Kent D., Tranah, Gregory J., Trompet, Stella, Uitterlinden, Andre G., Vasan, Ramachandran S., Westendorp, Rudi, Whitsel, Eric A., Wiggins, Kerri L., Wilson, James G.   +53 more
core   +19 more sources

Pharmacogenetics and Forensic Toxicology: A New Step towards a Multidisciplinary Approach

Toxics, 2021
Pharmacogenetics analyzes the individual behavior of DNA genes after the administration of a drug. Pharmacogenetic research has been implemented in recent years thanks to the improvement in genome sequencing techniques and molecular genetics. In addition
Nunzio Di Nunno, Massimiliano Esposito, Antonina Argo, Monica Salerno, Francesco Sessa   +4 more
doaj   +1 more source

Pharmacogenetics [PDF]

British Medical Bulletin, 1999
Inter-individual variability in drug response is a major clinical problem. Adverse drug reactions (ADRs) are common, are responsible for a number of debilitating side effects following drug therapy and are a significant cause of death. It is now clear that much of the observed variability in drug response has a genetic basis, arising as a result of ...
Wolf, C. Roland, Smith, Gillian
openaire   +2 more sources

Knowledge, perceptions and confidence of physicians and pharmacists towards pharmacogenetics practice in Kuwait. [PDF]

PLoS ONE, 2018
BACKGROUND:Pharmacogenetics practice has been successfully implemented in many developed countries to enhance personalized medicine and improve clinical and economic outcomes.
Abdullah Albassam, Shahad Alshammari, Ghadeer Ouda, Samuel Koshy, Abdelmoneim Awad   +4 more
doaj   +1 more source

Pharmacogenetics [PDF]

BMJ, 2001
Pharmacogenetics is the variability of drug response due to inherited characteristics in individuals. Drug metabolizing enzymes have been studied for decades, first as chemical reactions and, more recently, as specific polymorphisms of known molecules.
openaire   +5 more sources

Pharmacogenetics: Knowledge assessment amongst Syrian pharmacists and physicians

BMC Health Services Research, 2021
Background Pharmacogenetics targets genetic variations that influence drug response. It is relatively a new science that has not been vastly employed in most developing countries including Syria. Therefore we aimed at evaluating the depth of knowledge in
Lina Albitar, Ghalia Abou Alchamat
doaj   +1 more source

Genetic Diversity of HLA Class I and Class II Alleles in Thai Populations: Contribution to Genotype-Guided Therapeutics

Frontiers in Pharmacology, 2020
Human leukocyte antigen (HLA) class I and II are known to have association with severe cutaneous adverse reactions (SCARs) when exposing to certain drug treatment. Due to genetic differences at population level, drug hypersensitivity reactions are varied,
Patompong Satapornpong, Patompong Satapornpong, Patompong Satapornpong, Pimonpan Jinda, Pimonpan Jinda, Thawinee Jantararoungtong, Thawinee Jantararoungtong, Napatrupron Koomdee, Napatrupron Koomdee, Chonlawat Chaichan, Chonlawat Chaichan, Jirawat Pratoomwun, Jirawat Pratoomwun, Chalitpon Na Nakorn, Wichai Aekplakorn, Alisa Wilantho, Alisa Wilantho, Chumpol Ngamphiw, Chumpol Ngamphiw, Sissades Tongsima, Sissades Tongsima, Chonlaphat Sukasem, Chonlaphat Sukasem, Chonlaphat Sukasem   +23 more
doaj   +1 more source

Pharmacogenetic testing in oncology: a Brazilian perspective

Clinics, 2018
Pharmacogenetics, a major component of individualized or precision medicine, relies on human genetic diversity. The remarkable developments in sequencing technologies have revealed that the number of genetic variants modulating drug action is much higher
Guilherme Suarez-Kurtz
doaj   +1 more source

Context, ethics and pharmacogenetics [PDF]

, 2006
Most of the literature on pharmacogenetics assumes that the main problems in implementing the technology will be institutional ones (due to funding or regulation) and that although it involves genetic testing, the ethical issues involved in ...
Adam M. Hedgecoe, Akhtar, Anderson, Anon, Bazell, Beauchamp, Beeson, Brodaty, Brushwood, Clarke, DeVries, Emery, Ensom, Evans, Farlow, Farrer, Fox, Ginsburg, Haimes, Haseltine, Hedgecoe, Hedgecoe, Hoffmaster, Hoffmaster, Issa, Issa, Jazwinska, Johnson, Kumar, Kumar, Levine, Lindpaintner, Lindpaintner, McConnell, McLeod, Nelson, Noguchi, Nuffield Council on Bioethics., Palmer, Pfost, Poirier, Post, Relkin, Richard, Rioux, Ritchie, Robertson, Roses, Rothstein, Rusnak, Sadee, Saunders, Shi, Smith, Smith, Sugarman, Vaszar, Wolf, Zussman   +58 more
core   +1 more source

Cardiovascular pharmacogenetics [PDF]

Pharmacology & Therapeutics, 2012
Human genetic variation in the form of single nucleotide polymorphisms as well as more complex structural variations such as insertions, deletions and copy number variants, is partially responsible for the clinical variation seen in response to pharmacotherapeutic drugs.
Myburgh, Renier, Hochfeld, Warren Ernst, Dodgen, Tyren Mark, Ker, James A., Pepper, Michael Sean   +4 more
openaire   +3 more sources