Results 11 to 20 of about 46,119 (273)
Pharmacogenetics Guidelines: Overview and Comparison of the DPWG, CPIC, CPNDS, and RNPGx Guidelines
Frontiers in Pharmacology, 2021 Many studies have shown that the efficacy and risk of side effects of drug treatment is influenced by genetic variants. Evidence based guidelines are essential for implementing pharmacogenetic knowledge in daily clinical practice to optimize ...
H. Abdullah-Koolmees +3 more
semanticscholar +1 more source
CYP2D6 pharmacogenetics and phenoconversion in personalized medicine
Expert Opinion on Drug Metabolism & Toxicology, 2022 Introduction CYP2D6 contributes to the metabolism of approximately 20–25% of drugs. However, CYP2D6 is highly polymorphic and different alleles can lead to impacts ranging from null to increase in activity.
N. A. Nahid, Julie A. Johnson
semanticscholar +1 more source
British Medical Bulletin, 1999 Inter-individual variability in drug response is a major clinical problem. Adverse drug reactions (ADRs) are common, are responsible for a number of debilitating side effects following drug therapy and are a significant cause of death. It is now clear that much of the observed variability in drug response has a genetic basis, arising as a result of ...
Wolf, C. Roland, Smith, Gillian
openaire +2 more sources
Pharmacogenetics of Direct Oral Anticoagulants: A Systematic Review
Journal of Personalized Medicine, 2021 Dabigatran, rivaroxaban, apixaban, edoxaban, and betrixaban are direct oral anticoagulants (DOACs). Their inter-individual variability in pharmacodynamics and pharmacokinetics (transport and metabolism) is high, and could result from genetic ...
Johanna Raymond +6 more
semanticscholar +1 more source
Pharmacogenetics to guide cardiovascular drug therapy
Nature Reviews Cardiology, 2021 Over the past decade, pharmacogenetic testing has emerged in clinical practice to guide selected cardiovascular therapies. The most common implementation in practice is CYP2C19 genotyping to predict clopidogrel response and assist in selecting ...
Julio D. Duarte, L. Cavallari
semanticscholar +1 more source
Pharmacogenetics: Knowledge assessment amongst Syrian pharmacists and physicians
BMC Health Services Research, 2021 Background Pharmacogenetics targets genetic variations that influence drug response. It is relatively a new science that has not been vastly employed in most developing countries including Syria. Therefore we aimed at evaluating the depth of knowledge in
Lina Albitar, Ghalia Abou Alchamat
doaj +1 more source
Frontiers in Pharmacology, 2020 Human leukocyte antigen (HLA) class I and II are known to have association with severe cutaneous adverse reactions (SCARs) when exposing to certain drug treatment. Due to genetic differences at population level, drug hypersensitivity reactions are varied,
Patompong Satapornpong +23 more
doaj +1 more source
Pharmacogenetic testing in oncology: a Brazilian perspective
Clinics, 2018 Pharmacogenetics, a major component of individualized or precision medicine, relies on human genetic diversity. The remarkable developments in sequencing technologies have revealed that the number of genetic variants modulating drug action is much higher
Guilherme Suarez-Kurtz
doaj +1 more source
American Journal of Health-System Pharmacy, 2022 Purpose Healthcare professionals need a clear understanding of information about gene-drug interactions in order to make optimal use of pharmacogenetic (PGx) testing. In this report, we compare PGx information in the US Food and Drug Administration (FDA)
Daryl Pritchard +3 more
semanticscholar +1 more source
Pharmacogenetics of Antidepressants [PDF]
Frontiers in Pharmacology, 2011 Up to 60% of depressed patients do not respond completely to antidepressants (ADs) and up to 30% do not respond at all. Genetic factors contribute for about 50% of the AD response. During the recent years the possible influence of a set of candidate genes as genetic predictors of AD response efficacy was investigated by us and others.
Crisafulli C +6 more
openaire +6 more sources