Results 31 to 40 of about 46,119 (273)
The basic principals of pharmacogenetics testing in cancer treatment [PDF]
Hospital Pharmacology, 2020 Introduction: Precision medicine is an approach that considers genetics, environment and lifestyle factors when prevent and treat different diseases. The important part of precision medicine is pharmacogenetics, a branch of clinical pharmacology that ...
Cikota-Aleksić Bojana M. +3 more
doaj
Developmental Pharmacogenetics of CYP2D6 in Chinese Children: Loratadine as a Substrate Drug
Frontiers in Pharmacology, 2021 Objective: The elucidation of CYP2D6 developmental pharmacogenetics in children has improved, however, these findings have been largely limited to studies of Caucasian children.
Qian Li +12 more
doaj +1 more source
Clinical pharmacology and therapy, 2019 Thiopurine methyltransferase (TPMT) activity exhibits a monogenic codominant inheritance and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity and pronounced pharmacologic effects of thiopurines.
M. Relling +14 more
semanticscholar +1 more source
Cardiovascular pharmacogenetics [PDF]
Pharmacology & Therapeutics, 2012 Human genetic variation in the form of single nucleotide polymorphisms as well as more complex structural variations such as insertions, deletions and copy number variants, is partially responsible for the clinical variation seen in response to pharmacotherapeutic drugs.
Myburgh, Renier +4 more
openaire +3 more sources
Pharmacogenetics of asthma [PDF]
Current Opinion in Pulmonary Medicine, 2009 Patient response to the asthma drug classes, bronchodilators, inhaled corticosteroids and leukotriene modifiers, are characterized by a large degree of heterogeneity, which is attributable in part to genetic variation. Herein, we review and update the pharmacogenetics and pharmaogenomics of common asthma drugs.Early studies suggest that bronchodilator ...
John J, Lima +3 more
openaire +2 more sources
Clinical pharmacology and therapy, 2017 The purpose of this guideline is to provide information for the interpretation of clinical dihydropyrimidine dehydrogenase (DPYD) genotype tests so that the results can be used to guide dosing of fluoropyrimidines (5‐fluorouracil and capecitabine ...
U. Amstutz +10 more
semanticscholar +1 more source
Clinical pharmacology and therapy, 2017 CYP2D6 and CYP2C19 polymorphisms affect the exposure, efficacy and safety of tricyclic antidepressants (TCAs), with some drugs being affected by CYP2D6 only (e.g., nortriptyline and desipramine) and others by both polymorphic enzymes (e.g., amitriptyline,
J. Hicks +13 more
semanticscholar +1 more source
Pharmacogenetics in Clinical Practice
Prague Medical Report, 2012 Pharmacogenetics is a discipline that investigates how genetic variation relates to the drug efficacy and safety. The goal of pharmacogenetics is a personalized treatment, where according to genotype we would be able to prescribe the most effective drug ...
Hana Bakhouche, O. Slanař
doaj +1 more source
Clinical pharmacology and therapy, 2017 This document is an update to the 2011 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin dosing.
Julie A. Johnson +15 more
semanticscholar +1 more source
Human Molecular Genetics, 2001 Pharmacogenetics is the variability of drug response due to inherited characteristics in individuals. Drug metabolizing enzymes have been studied for decades, first as chemical reactions and, more recently, as specific polymorphisms of known molecules.
openaire +2 more sources