Results 31 to 40 of about 30,618 (276)
Pharmacogenetics of Direct Oral Anticoagulants: A Systematic Review
, 2021 Dabigatran, rivaroxaban, apixaban, edoxaban, and betrixaban are direct oral anticoagulants (DOACs). Their inter-individual variability in pharmacodynamics and pharmacokinetics (transport and metabolism) is high, and could result from genetic ...
Thibault Cousin +13 more
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Veterinary Clinics of North America: Small Animal Practice, 2006 Pharmacogenetics, the study of genetic determinants of response to drug therapy, is likely the ultimate way to establish the right drug and dose for each patient, thereby optimizing efficacy and minimizing toxicity. Despite the fact that this branch of pharmacology is still in its infancy as a science, a number of important discoveries have already ...
Decosterd, Laurent A. +3 more
core +3 more sources
The basic principals of pharmacogenetics testing in cancer treatment [PDF]
Hospital Pharmacology, 2020 Introduction: Precision medicine is an approach that considers genetics, environment and lifestyle factors when prevent and treat different diseases. The important part of precision medicine is pharmacogenetics, a branch of clinical pharmacology that ...
Cikota-Aleksić Bojana M. +3 more
doaj
Developmental Pharmacogenetics of CYP2D6 in Chinese Children: Loratadine as a Substrate Drug
Frontiers in Pharmacology, 2021 Objective: The elucidation of CYP2D6 developmental pharmacogenetics in children has improved, however, these findings have been largely limited to studies of Caucasian children.
Qian Li +12 more
doaj +1 more source
Cardiovascular pharmacogenetics [PDF]
Pharmacology & Therapeutics, 2012 Human genetic variation in the form of single nucleotide polymorphisms as well as more complex structural variations such as insertions, deletions and copy number variants, is partially responsible for the clinical variation seen in response to pharmacotherapeutic drugs.
Myburgh, Renier +4 more
openaire +3 more sources
COMPARISON OF CLINICAL PHARMACOGENETIC RECOMMENDATIONS ACROSS THERAPEUTIC AREAS
, 2022 OBJECTIVES: Evaluations from pharmacogenetics implementation programs at major U.S. medical centers have reported variability in the clinical adoption of pharmacogenetics across therapeutic areas.
Luzum, Jasmine A. +2 more
core +1 more source
Pharmacogenetics of asthma [PDF]
Current Opinion in Pulmonary Medicine, 2009 Patient response to the asthma drug classes, bronchodilators, inhaled corticosteroids and leukotriene modifiers, are characterized by a large degree of heterogeneity, which is attributable in part to genetic variation. Herein, we review and update the pharmacogenetics and pharmaogenomics of common asthma drugs.Early studies suggest that bronchodilator ...
John J, Lima +3 more
openaire +2 more sources
The effects of pharmacogenetics on pharmacokinetics of artemisinin-based combinations in malaria patients [PDF]
, 2009 Malaria is a vector-borne infectious disease caused by protozoan parasites of the genus Plasmodium. If not treated appropriately, human P. falciparum malaria can quickly become life-threatening, leading to an estimated 900’000 annual deaths globally. Key
Hodel, Eva Maria
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BMC Cancer, 2019 Background High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatment approach ...
Stefanie Klenke +5 more
doaj +1 more source
Systematic identification of non-coding pharmacogenomic landscape in cancer
Nature Communications, 2018 In this study the authors build lncRNA-drug response models for 265 anti-cancer agents across 27 cancer types. They report their cancer cell line based lncRNA EN-models are able to effectively predict therapeutic outcome for breast cancer, ovarian cancer,
Yue Wang +6 more
doaj +1 more source