Results 21 to 30 of about 34,080 (270)
BMC Pregnancy and Childbirth, 2017 Background Pharmacogenetics is an emerging field currently being implemented to improve safety when prescribing drugs. While many women who take drugs during pregnancy would likely benefit from such personalized drug therapy, data is lacking on the ...
Aizati N. A. Daud +7 more
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The basic principals of pharmacogenetics testing in cancer treatment [PDF]
Hospital Pharmacology, 2020 Introduction: Precision medicine is an approach that considers genetics, environment and lifestyle factors when prevent and treat different diseases. The important part of precision medicine is pharmacogenetics, a branch of clinical pharmacology that ...
Cikota-Aleksić Bojana M. +3 more
doaj
Developmental Pharmacogenetics of CYP2D6 in Chinese Children: Loratadine as a Substrate Drug
Frontiers in Pharmacology, 2021 Objective: The elucidation of CYP2D6 developmental pharmacogenetics in children has improved, however, these findings have been largely limited to studies of Caucasian children.
Qian Li +12 more
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Cardiovascular pharmacogenetics [PDF]
Pharmacology & Therapeutics, 2012 Human genetic variation in the form of single nucleotide polymorphisms as well as more complex structural variations such as insertions, deletions and copy number variants, is partially responsible for the clinical variation seen in response to pharmacotherapeutic drugs.
Myburgh, Renier +4 more
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Individualized immunosuppression in transplant patients: potential role of pharmacogenetics. [PDF]
, 2012 The immunosuppressive drugs used to prevent the rejection of transplanted organs have a narrow therapeutic index. Under treatment results in episodes of rejection leading to either damage or loss of the organ. Over immunosuppression increases the risk of
MacPhee IA +3 more
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The Oncologist, EarlyView., 2021 Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi +21 more
wiley +1 more source
BMC Cancer, 2019 Background High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatment approach ...
Stefanie Klenke +5 more
doaj +1 more source
Pharmacogenetics of asthma [PDF]
European Respiratory Journal, 2000 Pharmacogenetics offers the potential to optimize treatment for individual patients by using genetic information to improve efficacy or avoid side effects. While there are a number of examples in which the approach is already in routine clinical usage, exploitation of this approach in asthma is still under development.
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The effects of pharmacogenetics on pharmacokinetics of artemisinin-based combinations in malaria patients [PDF]
, 2009 Malaria is a vector-borne infectious disease caused by protozoan parasites of the genus Plasmodium. If not treated appropriately, human P. falciparum malaria can quickly become life-threatening, leading to an estimated 900’000 annual deaths globally. Key
Hodel, Eva Maria
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Pharmacogenetics of Asthma [PDF]
American Journal of Respiratory and Critical Care Medicine, 2002 Recent advances in the extent of knowledge regarding interindividual genetic variation in drug treatment targets and drug metabolizing enzymes has resulted in studies designed to assess the contribution of genetic variability to treatment response in a range of diseases. This review describes the current state of knowledge of genetic variability in key
Lyle J, Palmer +3 more
openaire +4 more sources