Results 21 to 30 of about 30,618 (276)
Frontiers in Pharmacology, 2020 Human leukocyte antigen (HLA) class I and II are known to have association with severe cutaneous adverse reactions (SCARs) when exposing to certain drug treatment. Due to genetic differences at population level, drug hypersensitivity reactions are varied,
Patompong Satapornpong +23 more
doaj +1 more source
, 2023 There has been a worldwide substantial increase in accidental opioid-overdose deaths. The aim of this review, along with preliminary results from our pilot study, is to highlight the use of pharmacogenetics as a tool to predict causes of accidental ...
Bernard Le Foll +11 more
core +1 more source
Pharmacogenetic testing in oncology: a Brazilian perspective
Clinics, 2018 Pharmacogenetics, a major component of individualized or precision medicine, relies on human genetic diversity. The remarkable developments in sequencing technologies have revealed that the number of genetic variants modulating drug action is much higher
Guilherme Suarez-Kurtz
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From pharmacogenetics to pharmaco-omics: Milestones and future directions
HGG Advances, 2022 The origins of pharmacogenetics date back to the 1950s, when it was established that inter-individual differences in drug response are partially determined by genetic factors.
Chiara Auwerx +3 more
doaj +1 more source
The pharmacogenetics of imanitib [PDF]
Genome Medicine, 2010 Imatinib mesylate (IM), a tyrosine kinase inhibitor, is one of the first molecularly targeted therapies to have been used in the clinic. It has proven to be efficient in the treatment of chronic myeloid leukemia and also in other malignancies that involve expression of a tyrosine kinase.
Dulucq, Stéphanie, Krajinovic, Maja
openaire +2 more sources
Pharmacogenetics of Antidepressants [PDF]
Frontiers in Pharmacology, 2011 Up to 60% of depressed patients do not respond completely to antidepressants (ADs) and up to 30% do not respond at all. Genetic factors contribute for about 50% of the AD response. During the recent years the possible influence of a set of candidate genes as genetic predictors of AD response efficacy was investigated by us and others.
Crisafulli C +6 more
openaire +6 more sources
Acta Pharmaceutica Sinica B, 2022 Combination of passive targeting with active targeting is a promising approach to improve the therapeutic efficacy of nanotherapy. However, most reported polymeric systems have sizes above 100 nm, which limits effective extravasation into tumors that are
Pearl Moharil +12 more
doaj +1 more source
Some aspects of genetics and pharmacogenetics understanding by pharmacy students in Ukraine
Egyptian Journal of Medical Human Genetics, 2015 Background: Prescription and administration of drugs are still carried out without taking into consideration the individual’s needs of a particular patient on the post-Soviet territory.
O.V. Filiptsova +2 more
doaj +1 more source
Pharmacogenetics of osteoporosis [PDF]
Best Practice & Research Clinical Endocrinology & Metabolism, 2010 Osteoporosis is a complex bone disorder with a strong genetic basis. The genetics of osteoporosis encompasses two main areas: genetics of disease susceptibility and pharmacogenetics of drug response. The former has been widely studied in the past few decades, while the latter is still largely untouched.
MARINI, FRANCESCA, BRANDI, MARIA LUISA
openaire +7 more sources
BMC Pregnancy and Childbirth, 2017 Background Pharmacogenetics is an emerging field currently being implemented to improve safety when prescribing drugs. While many women who take drugs during pregnancy would likely benefit from such personalized drug therapy, data is lacking on the ...
Aizati N. A. Daud +7 more
doaj +1 more source