Results 41 to 50 of about 30,618 (276)

Pharmacogenetics of asthma [PDF]

European Respiratory Journal, 2000
Pharmacogenetics offers the potential to optimize treatment for individual patients by using genetic information to improve efficacy or avoid side effects. While there are a number of examples in which the approach is already in routine clinical usage, exploitation of this approach in asthma is still under development.
openaire   +3 more sources

Integrating rare genetic variants into pharmacogenetic drug response predictions

Human Genomics, 2018
Background Variability in genes implicated in drug pharmacokinetics or drug response can modulate treatment efficacy or predispose to adverse drug reactions.
Magnus Ingelman-Sundberg, Souren Mkrtchian, Yitian Zhou, Volker M. Lauschke   +3 more
doaj   +1 more source

miRNAs as Key Players in the Management of Cutaneous Melanoma

Cells, 2020
The number of treatment options for melanoma patients has grown in the past few years, leading to considerable improvements in both overall and progression-free survival.
Celeste Lorusso, Simona De Summa, Rosamaria Pinto, Katia Danza, Stefania Tommasi   +4 more
doaj   +1 more source

Individualized immunosuppression in transplant patients: potential role of pharmacogenetics.

, 2012
The immunosuppressive drugs used to prevent the rejection of transplanted organs have a narrow therapeutic index. Under treatment results in episodes of rejection leading to either damage or loss of the organ. Over immunosuppression increases the risk of
MacPhee IA, Abboudi H, Macphee, IA, Abboudi, H   +3 more
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Pharmacogenetics of Asthma [PDF]

American Journal of Respiratory and Critical Care Medicine, 2002
Recent advances in the extent of knowledge regarding interindividual genetic variation in drug treatment targets and drug metabolizing enzymes has resulted in studies designed to assess the contribution of genetic variability to treatment response in a range of diseases. This review describes the current state of knowledge of genetic variability in key
Lyle J, Palmer, Eric S, Silverman, Scott T, Weiss, Jeffrey M, Drazen   +3 more
openaire   +4 more sources

ACTH receptor (MC2R) promoter variants associated with infantile spasms modulate MC2R expression and responsiveness to ACTH

, 2010
Objective Adrenocorticotropin hormone (ACTH) has been the standard treatment to infantile spasms (IS). However, the mechanism of ACTH therapy is still unclear. ACTH exerts the function via melanocortin 2 receptor (MC2R).
He, Bing, Zhang, Dai, Zhang, D, Yue, W-H, Zou, Li-Ping, Liu, Zhan-Li, Ding, Y-X, Liu, Z-L, Yue, Wei-Hua, Zou, L-P, He, B,, Ding, Ying-Xue   +11 more
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Establishment of a Pharmacogenetics Service Focused on Optimizing Existing Pharmacogenetic Testing at a Large Academic Health Center

, 2020
Multiple groups have described strategies for clinical implementation of pharmacogenetics (PGx) that often include internal laboratory tests that are specifically developed for their implementation needs. However, many institutions are not able to follow
Mohammad B. Ateya, Hae Mi Choe, Amy L. Pasternak, John S. Clark, Vicki Ellingrod, Kristen M. Ward, Amy N. Thompson   +6 more
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Estimated nationwide impact of implementing a preemptive pharmacogenetic panel approach to guide drug prescribing in primary care in The Netherlands

BMC Medicine, 2019
Background Pharmacogenetics (PGx) is currently implemented in hospitals to optimize therapy with high-risk drugs. However, many drugs with dosing recommendations from the Dutch Pharmacogenetics Working Group and the Clinical Pharmacogenetics ...
P. C. D. Bank, J. J. Swen, H. J. Guchelaar   +2 more
doaj   +1 more source

Pharmacogenetics of OPRM1 [PDF]

Pharmacology Biochemistry and Behavior, 2014
Pharmacogenetic research has the potential to explain the variation in treatment efficacy within patient populations. Understanding the interaction between genetic variation and medications may provide a method for matching patients to the most effective therapeutic options and improving overall patient outcomes.
Richard C, Crist, Wade H, Berrettini
openaire   +2 more sources

Pharmacogenetics and the Pharmacy Profession: A Sociological Exploration [PDF]

, 2012
Pharmacy, particularly in the community setting, has been subject to significant changes over the last three decades. Running concurrently to these changes has been the development of the field of pharmacogenetics, or ‘personalised medicine’, which is ...
Jamie, Kimberly
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