Results 41 to 50 of about 34,080 (270)

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel. [PDF]

Clin Pharmacol Ther
The Clinical Pharmacogenetics Implementation Consortium (CPIC) TPMT/NUDT15 Pharmacogene Curation Expert Panel (PCEP) conducted a comprehensive review of clinical, laboratory, and computational evidence to determine the clinical function assignments for TPMT and NUDT15 star alleles.
Tibben BM, Maillard M, Pratt VM, Moyer AM, Figueroa DM, Whirl-Carrillo M, Gaedigk A, Stocco G, Schwab M, Caudle KE, Yang JJ.   +10 more
europepmc   +2 more sources

ANK1 and EPB41 Variants and The Risk of Glucocorticoid‐Induced Osteonecrosis

Arthritis &Rheumatology, EarlyView.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Pharmacogenetics of Antipsychotics [PDF]

The Canadian Journal of Psychiatry, 2014
Objective: During the past decades, increasing efforts have been invested in studies to unravel the influence of genetic factors on antipsychotic (AP) dosage, treatment response, and occurrence of adverse effects.
Eva J, Brandl, James L, Kennedy, Daniel J, Müller   +2 more
openaire   +2 more sources

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Establishment of a Pharmacogenetics Service Focused on Optimizing Existing Pharmacogenetic Testing at a Large Academic Health Center

, 2020
Multiple groups have described strategies for clinical implementation of pharmacogenetics (PGx) that often include internal laboratory tests that are specifically developed for their implementation needs. However, many institutions are not able to follow
Mohammad B. Ateya, Hae Mi Choe, Amy L. Pasternak, John S. Clark, Vicki Ellingrod, Kristen M. Ward, Amy N. Thompson   +6 more
core   +1 more source

An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy

Nature Communications, 2016
The use of immunostimulatory agents to enhance the efficacy of chemotherapy is a promising strategy in cancer therapy. Here, the authors report on a micellar nanoparticle that can effectively co-deliver chemo- and immunotherapeutics, resulting in an ...
Yichao Chen, Rui Xia, Yixian Huang, Wenchen Zhao, Jiang Li, Xiaolan Zhang, Pengcheng Wang, Raman Venkataramanan, Jie Fan, Wen Xie, Xiaochao Ma, Binfeng Lu, Song Li   +12 more
doaj   +1 more source

ACTH receptor (MC2R) promoter variants associated with infantile spasms modulate MC2R expression and responsiveness to ACTH

, 2010
Objective Adrenocorticotropin hormone (ACTH) has been the standard treatment to infantile spasms (IS). However, the mechanism of ACTH therapy is still unclear. ACTH exerts the function via melanocortin 2 receptor (MC2R).
He, Bing, Zhang, Dai, Zhang, D, Yue, W-H, Zou, Li-Ping, Liu, Zhan-Li, Ding, Y-X, Liu, Z-L, Yue, Wei-Hua, Zou, L-P, He, B,, Ding, Ying-Xue   +11 more
core   +1 more source

CRISPR activation screens identify oncogenic lncRNAs that are susceptible to CDK4/6 inhibitor treatment

Nature Communications
The roles of long non-coding RNAs (lncRNAs) in tumorigenesis and therapeutic response remain largely unknown. Here we perform genome-wide and focused CRISPR activation screens to identify lncRNAs regulating palbociclib response in breast cancer cells.
Yifei Wang, Yueshan Zhao, Jiaxin Hu, Zehua Wang, Dhamotharan Pattarayan, Sihan Li, Yu Zhang, Xiaofei Wang, Yue Wang, Wen Xie, Min Zhang, Da Yang   +11 more
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

CDK4/6 inhibitors in metastatic breast cancer: Pharmacogenetics of ADME genes to predict differences in toxicity and treatment schedule adherence

, 2022
reservedCDK4/6 inhibitors, palbociclib, ribociclib, abemaciclib, are the gold standard for the treatment of luminal-like metastatic breast cancer.
NUZZO, SOFIA
core