Results 41 to 50 of about 13,476,144 (183)

Effect of a hyaluronic acid‐based mesotherapeutic injectable on the gene expression of CLOCK and Klotho proteins, and environmentally induced oxidative stress in human skin cells

Journal of Cosmetic Dermatology, Volume 22, Issue 1, Page 156-172, January 2023., 2023
Abstract Objective Normal circadian rhythms are essential to the repair mechanisms of oxidative stress implicated in skin aging. Given reports that hyaluronic acid (HA) homeostasis exhibits a different profile in chronological skin aging, as compared to environmental or extrinsic aging, an improved understanding of the way HA interacts with its ...
Aleksei Prokopov, Anna Drobintseva, Igor Kvetnoy, Zarema Gazitaeva, Anna Sidorina   +4 more
wiley   +1 more source

Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey. [PDF]

PLoS ONE, 2011
Arylamine N-acetyltransferase 2 (NAT2) is involved in human physiological responses to a variety of xenobiotic compounds, including common therapeutic drugs and exogenous chemicals present in the diet and the environment.
Audrey Sabbagh, Pierre Darlu, Brigitte Crouau-Roy, Estella S Poloni   +3 more
doaj   +1 more source

Air pollution induces Staphylococcus aureus USA300 respiratory tract colonization mediated by specific bacterial genetic responses involving the global virulence gene regulators Agr and Sae

Environmental Microbiology, Volume 24, Issue 9, Page 4449-4465, September 2022., 2022
Summary Exposure to particulate matter (PM), a major component of air pollution, is associated with exacerbation of chronic respiratory disease, and infectious diseases such as community‐acquired pneumonia. Although PM can cause adverse health effects through direct damage to host cells, our previous study showed that PM can also impact bacterial ...
Jo Purves, Shane J. K. Hussey, Louise Corscadden, Lillie Purser, Andie Hall, Raju Misra, Liza Selley, Paul S. Monks, Julian M. Ketley, Peter W. Andrew, Julie A. Morrissey   +10 more
wiley   +1 more source

NAT2 and CYP2E1 polymorphisms and antituberculosis drug‐induced hepatotoxicity in Peruvian patients

Molecular Genetics &Genomic Medicine, Volume 10, Issue 8, August 2022., 2022
According to our results, the combination of the NAT2 polymorphism associated with the intermediate phenotype and the CYP2E1 C1/C1 genotype associated with the slow phenotype does not affect the therapeutic response and is suspected to be a protective factor against INH‐induced hepatotoxicity in Peruvian tuberculosis patients.
Luis Jaramillo‐Valverde, Kelly S. Levano, David D. Tarazona, Silvia Capristano, Roberto Zegarra‐Chapoñan, Cesar Sanchez, Velia M. Yufra‐Picardo, Eduardo Tarazona‐Santos, Cesar Ugarte‐Gil, Heinner Guio   +9 more
wiley   +1 more source

Characterisation of Sulfolobus solfataricus Ard1, a promiscuous N-acetyltransferase [PDF]

, 2008
Compaction of DNA into chromatin is an important feature of every living cell. This compaction phenomenon is brought about and maintained by a variety of DNA binding proteins, which have evolved to suit the specific needs of the different cell types ...
Mackay, Dale Tara
core   +2 more sources

Structure and Mechanism of Arylamine N-Acetyltransferases

Current Topics in Medicinal Chemistry, 2006
Arylamine N-acetyltransferases (NATs) are a family of phase II drug-metabolising enzymes which are important in the biotransformation of various aromatic and heterocyclic amines and hydroxylamines, arylhydrazines and arylhydrazides. NATs are present in a wide range of eukaryotes and prokaryotes.
Westwood, I, Kawamura, A, Fullam, E, Russell, A, Davies, S, Sim, E   +5 more
openaire   +3 more sources

NAT1 (N-acetyltransferase 1 (arylamine N-acetyltransferase)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on NAT1 (N-acetyltransferase 1 (arylamine N-acetyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ruiz, JD, Agúndez, JAG, Martínez, C, García-Martín, E   +3 more
openaire   +2 more sources

Determination of Human NAT2 Acetylator Genotype by Oligonucleotide Ligation Assay

BioTechniques, 1997
The oligonucleotide ligation assay (OLA) was adapted to the genotyping of the N-arylamine-acetyltransferase (NAT2) gene. This assay allows the use of 96-well microplates and robotic workstations for high sample throughput.
Jeannette Bigler, Chu Chen, John D. Potter   +2 more
doaj   +1 more source

Hepatotoxicity during TB treatment in people with HIV/AIDS related to NAT2 polymorphisms in Pernambuco, Northeast Brazil

Annals of Hepatology, 2020
Introduction and objective: Hepatotoxicity during tuberculosis (TB) treatment is frequent and may be related to the Arylamine N-Acetyltransferase (NAT2) acetylator profile, in which allele frequencies differ according to the population.
Carolline Araujo-Mariz, Maria de Fátima P. Militão de Albuquerque, Edmundo P. Lopes, Ricardo A.A. Ximenes, Heloísa R. Lacerda, Demócrito B. Miranda-Filho, Brena B. Lustosa-Martins, André Filipe P. Pastor, Bartolomeu Acioli-Santos   +8 more
doaj   +1 more source

A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1. [PDF]

PLoS ONE, 2013
Human arylamine N-acetyltransferase 1 (hNAT1) has become an attractive potential biomarker for estrogen-receptor-positive breast cancers. We describe here the mechanism of action of a selective non-covalent colorimetric biosensor for the recognition of ...
Nicola Laurieri, James E Egleton, Amy Varney, Cyrille C Thinnes, Camilo E Quevedo, Peter T Seden, Sam Thompson, Fernando Rodrigues-Lima, Julien Dairou, Jean-Marie Dupret, Angela J Russell, Edith Sim   +11 more
doaj   +1 more source