Results 61 to 70 of about 13,476,144 (183)

Research Status and Prospects of Helicobacter pylori–associated gastritis: From Mechanisms to Traditional Chinese Medicine Treatment

Gastroenterology Research and Practice, Volume 2026, Issue 1, 2026.
Helicobacter pylori–associated gastritis (HPAG) is a chronic inflammatory condition of the gastric mucosa caused by Helicobacter pylori infection, serving as the core etiological factor for peptic ulcers and gastric precancerous lesions. Given the persistently high global infection rates and the escalating burden of antibiotic resistance, conventional ...
Zhongyao Fan, Ziling Jin, Caiyue Liu, Ruifan Hu, Weiqiang Li, Neetu Rawal   +5 more
wiley   +1 more source

Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation [PDF]

, 2012
Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral ...
Centner, Chad
core   +1 more source

Identification of Anoikis‐Related Subgroups and Prognosis Model in Colon Cancer

Cancer Nexus, Volume 1, Issue 2, July 2025.
ABSTRACT Background Anoikis represents a distinct type of programmed cell death that serves a critical function in tumor development and metastatic. Despite its significance, there remains a notable gap in comprehensive studies that explore the role of Anoikis specifically within the context of colon cancer (CC). Thus, it becomes imperative to pinpoint
Shaokang Yang, Peng Yang, Zhicheng Liu, Yujia Chen, Qitong He, Daguang Wang   +5 more
wiley   +1 more source

Characterization of NAT, GST, and CYP2E1 Genetic Variation in Sub‐Saharan African Populations: Implications for Treatment of Tuberculosis and Other Diseases

Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1338-1357, May 2025.
Tuberculosis (TB) is a major health burden in Africa. Although TB is treatable, anti‐TB drugs are associated with adverse drug reactions (ADRs), which are partly attributed to pharmacogenetic variation. The distribution of star alleles (haplotypes) influencing anti‐TB drug metabolism is unknown in many African populations.
Thandeka V.B. Malinga, Houcemeddine Othman, Maria Paximadis, Caroline T. Tiemessen, Michèle Ramsay, Scott Hazelhurst, David Twesigomwe   +6 more
wiley   +1 more source

Human Arylamine N-Acetyltransferase Type 1

, 2018
Human arylamine N-acetyltransferase 1 (NAT1) is one of the two functional NATs in humans that acetylate primary arylamine and hydrazine xenobiotics. There is a growing body of evidence that suggests NAT1 may have an important physiological role in the ...
Rodney F. Minchin, Wang, Lili, Li, Pengcheng, Minchin, Rodney F., Neville J. Butcher, Pengcheng Li, Butcher, Neville J., Lili Wang   +7 more
core   +1 more source

Effects of single nucleotide polymorphisms on human N-acetyltransferase 2 structure and dynamics by molecular dynamics simulation. [PDF]

PLoS ONE, 2011
BACKGROUND: Arylamine N-acetyltransferase 2 (NAT2) is an important catalytic enzyme that metabolizes the carcinogenic arylamines, hydrazine drugs and chemicals. This enzyme is highly polymorphic in different human populations.
M Rajasekaran, Santhanam Abirami, Chinpan Chen   +2 more
doaj   +1 more source

Metabolic Engineering of a Serotonin Overproducing Saccharomyces cerevisiae Strain

Microbial Biotechnology, Volume 18, Issue 4, April 2025.
Yeast strain engineered for serotonin production. The medium and fermentation conditions have been optimised to achieve the highest serotonin production of any S. cerevisiae strain to date. ABSTRACT The EU Green Deal prioritises the transformation of the chemical industry to a more environmentally sustainable model.
Andrés Planells‐Cárcel, Elena Valera‐García, Guillermo Quintas, José Luis Martínez, Sara Muñiz‐Calvo, José Manuel Guillamón   +5 more
wiley   +1 more source

Arylamine N-Acetyltransferase in Mycobacteria

, 2018
Arylamine N-acetyltransferase (NAT) was first identified in humans for its role in metabolising the anti-tubercular drug isoniazid. Later functional NAT proteins were identified in bacteria including Mycobacterium tuberculosis where they were found to N ...
Sanjib Bhakta, Bhakta, Sanjib, Evangelopoulos, Dimitrios, Dimitrios Evangelopoulos   +3 more
core   +1 more source

Evolutionary formation of melatonin and vitamin D in early life forms: insects take centre stage

Biological Reviews, Volume 99, Issue 5, Page 1772-1790, October 2024.
ABSTRACT Melatonin, a product of tryptophan metabolism via serotonin, is a molecule with an indole backbone that is widely produced by bacteria, unicellular eukaryotic organisms, plants, fungi and all animal taxa. Aside from its role in the regulation of circadian rhythms, it has diverse biological actions including regulation of cytoprotective ...
Tae‐Kang Kim, Radomir M. Slominski, Elzbieta Pyza, Konrad Kleszczynski, Robert C. Tuckey, Russel J. Reiter, Michael F. Holick, Andrzej T. Slominski   +7 more
wiley   +1 more source

Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate

, 2018
In the present study, a screen of adenosine analogs as potential modulators of arylamine-N-acetyltransferase 1 activity identified ATP as an inhibitor within its range of physiological concentrations. Kinetically, ATP was a non-competitive inhibitor with
Burow, Rachel, Rosengren, K. Johan, Minchin, Rodney F., Butcher, Neville J.   +3 more
core   +1 more source