Results 61 to 70 of about 2,402 (195)

Environmental Pesticide Exposure in the Etiology of Pediatric Brain Tumors and Leukemia: A Scoping Review of Epidemiological Studies

International Journal of Cancer, Volume 159, Issue 6, Page 1360-1384, 15 September 2026.
ABSTRACT Pediatric cancer is a significant cause of morbidity and mortality in children. The etiologies of pediatric cancer are largely unknown, but environmental pesticide exposures are likely to contribute. Chronic low‐dose exposure to pesticide mixtures through drinking water is a growing concern in agricultural communities.
Grace N. VanDeSteeg, Alyssa R. Russum, Matthew R. Sandbulte, Eleanor G. Rogan, Martha G. Rhoades   +4 more
wiley   +1 more source

Genomic and Sex Contributions to Interindividual Variability in Pitavastatin Bioavailability

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT Aim This study investigates pharmacogenetic determinants of pitavastatin disposition using a candidate‐gene approach. Methods In 48 healthy volunteers, 138 variants across 40 genes involved in drug metabolism and transport were analysed to assess their relationship with pitavastatin pharmacokinetics, alongside the influence of sex and ...
Eva González‐Iglesias, Sofía Moreno‐Pérez de Villar, Dolores Ochoa, Manuel Román, Jesús Novalbos, Samuel Martín‐Vilchez, Alejandro de Miguel, Francisco Abad‐Santos   +7 more
wiley   +1 more source

PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 859-871, April 2026.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou, Estella S. Poloni, José A.G. Agúndez, Raquel L.F. Teixeira, Erin C. Boone, Adalberto Rezende Santos, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Mariam R. Habil, Giannoulis Fakis, Rodney F. Minchin, David W. Hein, Sotiria Boukouvala, Andrea Gaedigk   +14 more
wiley   +1 more source

Genetic Variant of Arylamine N-Acetyltransferase-2 G590A Polymorphism (rs1799930) in Xenobiotic Biotransformation and Tobacco-associated Periodontitis: A Cross-sectional Observational Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Xenobiotic compounds in tobacco smoke necessitate metabolic detoxification via N-acetyltransferase enzymes; individuals harbouring the N-Acetyltransferase-2 (NAT2) (G590A) polymorphism exhibit impaired biotransformation proficiency, thereby
Dhathri Priya Bandi, Dhayanand John Victor, Sangeetha Subramanian, Balasubramanian Krishnaswamy   +3 more
doaj   +1 more source

Multifaceted Small Molecules as Enzyme Modulators: Cases of Drug Discovery/Repurposing Illustrating Nature′s Pragmatism

BioMed Research International, Volume 2026, Issue 1, 2026.
The cross‐reactivity of substrates, modulators with other enzymes significantly reduces/prevents our ability to design such highly specific, that is, “one warhead–one target”, modulators. On the other hand, the potential “impasse” fuels repurposing of already developed drugs.
Monika I. Konaklieva, Balbina J. Plotkin, Nahit Gencer   +2 more
wiley   +1 more source

Identification of Anoikis‐Related Subgroups and Prognosis Model in Colon Cancer

Cancer Nexus, Volume 1, Issue 2, July 2025.
ABSTRACT Background Anoikis represents a distinct type of programmed cell death that serves a critical function in tumor development and metastatic. Despite its significance, there remains a notable gap in comprehensive studies that explore the role of Anoikis specifically within the context of colon cancer (CC). Thus, it becomes imperative to pinpoint
Shaokang Yang, Peng Yang, Zhicheng Liu, Yujia Chen, Qitong He, Daguang Wang   +5 more
wiley   +1 more source

Characterisation of Sulfolobus solfataricus Ard1, a promiscuous N-acetyltransferase [PDF]

, 2008
Compaction of DNA into chromatin is an important feature of every living cell. This compaction phenomenon is brought about and maintained by a variety of DNA binding proteins, which have evolved to suit the specific needs of the different cell types ...
Mackay, Dale Tara
core  

New spectrophotometric and radiochemical assays for acetyl-CoA: Arylamine N-acetyltransferase applicable to a variety of arylamines [PDF]

, 1984
Simple and sensitive spectrophotometric and radiochemical procedures are described for the assay of acetyl-CoA:arylamine N-acetyltransferase (NAT; EC 2.3.1.5), which catalyzes the reaction acetyl-CoA + arylamine --> N-acetylated arylamine + CoASH. The
Susan M. Szabo, Andres, Herbert H., Antje J. U-em, W. Weber, Wendell, Szabo, Susan M., Herbert H. Andre, Klem, Antje J., Weber, Wendell W.   +8 more
core   +1 more source

Protein-ligand interactions of arylamine N-acetyltransferase from Mycobacterium smegmatis [PDF]

, 2003
Tuberculosis is the world's largest cause of death from an infectious agent. Treatment is by an extended period of combination chemotherapy. Drug resistance is an increasing problem in tuberculosis therapy, particularly to the frontline anti-tubercular ...
Prof. E. Sim, Brooke, Edward W., Sim, E. (Edith)   +2 more
core   +4 more sources

Characterization of NAT, GST, and CYP2E1 Genetic Variation in Sub‐Saharan African Populations: Implications for Treatment of Tuberculosis and Other Diseases

Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1338-1357, May 2025.
Tuberculosis (TB) is a major health burden in Africa. Although TB is treatable, anti‐TB drugs are associated with adverse drug reactions (ADRs), which are partly attributed to pharmacogenetic variation. The distribution of star alleles (haplotypes) influencing anti‐TB drug metabolism is unknown in many African populations.
Thandeka V.B. Malinga, Houcemeddine Othman, Maria Paximadis, Caroline T. Tiemessen, Michèle Ramsay, Scott Hazelhurst, David Twesigomwe   +6 more
wiley   +1 more source