Metabolic Engineering of a Serotonin Overproducing Saccharomyces cerevisiae Strain
Microbial Biotechnology, Volume 18, Issue 4, April 2025.Yeast strain engineered for serotonin production. The medium and fermentation conditions have been optimised to achieve the highest serotonin production of any S. cerevisiae strain to date. ABSTRACT The EU Green Deal prioritises the transformation of the chemical industry to a more environmentally sustainable model.
Andrés Planells‐Cárcel +5 more
wiley +1 more source
Tropomyosins, N-terminal acetylation and their impact on yeast cytoskeletal function: A characterisation of novel tropomyosins from N. crassa and the N-terminal acetyltransferase, Nat3p [PDF]
, 2009 PhDWhile the fundamental role of tropomyosins (Tms) in the maintenance of the actin cytoskeleton in yeast is established, details of their exact regulatory functions in lower eukaryotes remains to be deciphered.
Ebrahim, Seham
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Role of human arylamine N-acetyltransferase in carcinogen metabolism and human breast cancer progression. [PDF]
, 2012 Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and ...
Leggett, Carmine Simone
core +2 more sources
Evolutionary formation of melatonin and vitamin D in early life forms: insects take centre stage
Biological Reviews, Volume 99, Issue 5, Page 1772-1790, October 2024.ABSTRACT Melatonin, a product of tryptophan metabolism via serotonin, is a molecule with an indole backbone that is widely produced by bacteria, unicellular eukaryotic organisms, plants, fungi and all animal taxa. Aside from its role in the regulation of circadian rhythms, it has diverse biological actions including regulation of cytoprotective ...
Tae‐Kang Kim +7 more
wiley +1 more source
N-acetyltransferase polymorphism in patients with Behcet's disease [PDF]
, 2001 Objectives: The objective of our study was to investigate the possible role of human arylamine N-acetyltransferase 2 (NAT2) polymorphism in susceptibility to Behcet's ...
Aynacioglu, AS +6 more
core +1 more source
Effects of single nucleotide polymorphisms on human N-acetyltransferase 2 structure and dynamics by molecular dynamics simulation. [PDF]
PLoS ONE, 2011 BACKGROUND: Arylamine N-acetyltransferase 2 (NAT2) is an important catalytic enzyme that metabolizes the carcinogenic arylamines, hydrazine drugs and chemicals. This enzyme is highly polymorphic in different human populations.
M Rajasekaran +2 more
doaj +1 more source
American Journal of Human Biology, Volume 36, Issue 4, April 2024.Abstract Objectives Previous research revealed that in some African populations, food‐production strategies are associated with facial shape. Nomadic pastoralists living in the African Sahel/Savannah belt have a different facial morphology than their sedentary neighbors. We investigated whether the lifestyle associated with a subsistence pattern has an
Karel Kleisner +2 more
wiley +1 more source
Leukocytoclastic vasculitis caused by sulfamethoxazole‐trimethoprim
Clinical Case Reports, Volume 12, Issue 2, February 2024.Violaceous round papules and a surrounding rim of macular purpura coalescing into plaques on both feet 8 days after starting sulfamethoxazole‐trimethoprim. Key Clinical Message Leukocytoclastic vasculitis is a rare, small‐vessel vasculitis that can be caused by sulfamethoxazole‐trimethoprim.
Parjanya Bhatt +5 more
wiley +1 more source
Arylamine N-Acetyltransferases in Anthropology
, 2018 Abstract Among the many genes involved in the metabolism of therapeutic drugs, human arylamine N-acetyltransferases (NATs) genes have been extensively studied, due to their medical importance both in pharmacogenetics and disease epidemiology. One member of this small gene family, NAT2, is established as the locus of the classic human acetylation ...
Sabbagh, Audrey +3 more
openaire +4 more sources
Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation [PDF]
, 2012 Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral ...
Centner, Chad
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